A
Anders Björklund
Researcher at Lund University
Publications - 771
Citations - 87172
Anders Björklund is an academic researcher from Lund University. The author has contributed to research in topics: Transplantation & Dopamine. The author has an hindex of 165, co-authored 769 publications receiving 84268 citations. Previous affiliations of Anders Björklund include University of Washington & Institute for the Study of Labor.
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Evidence for regenerative axon sprouting of central catecholamine neurons in the rat mesencephalon following electrolytic lesions
TL;DR: Evidence has been obtained for regenerative sprouting of axons from catecholamine neurons in the rat mesencephalon 1–7 weeks after electrolytic destruction of the substantia nigra and part of the ventromedial midbrain tegmentum, the first direct evidence of regeneration of central monoamine fibers.
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Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system
TL;DR: It is reported that an intracerebroventricular injection of this 192 IgG-saporin conjugate induces a severe, long-lasting spatial learning impairment, as assessed in the Morris water-maze task.
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Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor.
TL;DR: It is concluded that preservation of normal motor functions in the intrastriatal 6‐OHDA lesion model requires protection of striatal terminal innervation, and that this can be achieved by intrastRIatal, but not nigral or intraventricular, administration of GDNF.
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Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
Stina Friling,Elisabet Andersson,Lachlan H. Thompson,Marie E. Jönsson,Josephine B. Hebsgaard,Evanthia Nanou,Zhanna Alekseenko,Ulrika Marklund,Susanna Kjellander,Nikolaos Volakakis,Outi Hovatta,Abdeljabbar El Manira,Anders Björklund,Thomas Perlmann,Johan Ericson +14 more
TL;DR: forced expression of Lmx1a, a transcription factor functioning as a determinant of mesDA neurons during embryogenesis, effectively can promote the generation of mes DA neurons from mouse and human ESCs, which may be of future importance in cell replacement therapy of Parkinson disease.
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Dopamine-containing cells in sympathetic ganglia.
TL;DR: Dopamine was found in a special type of small, intensely fluorescent cells (“SIF-cells”) located among the adrenergic ganglion cell bodies, most of the dopamine present in the sympathetic ganglia is probably stored in these cells.