A
Anders Björklund
Researcher at Lund University
Publications - 771
Citations - 87172
Anders Björklund is an academic researcher from Lund University. The author has contributed to research in topics: Transplantation & Dopamine. The author has an hindex of 165, co-authored 769 publications receiving 84268 citations. Previous affiliations of Anders Björklund include University of Washington & Institute for the Study of Labor.
Papers
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Journal ArticleDOI
Intracephalic embryonic neural implants in the adult rat brain. I. Growth and mature organization of birainstem, cerebellar, and hippocampal implants
TL;DR: Implants of embryonic CNS tissue, dissected from the developing brainstem, cerebellum, and hippocampus of rat fetuses, were analyzed after 2–14 months survival in an intracephalic transplantation cavity in adult host rats.
Journal ArticleDOI
Neuroprotective and behavioral efficacy of nerve growth factor—transfected hippocampal progenitor cell transplants after experimental traumatic brain injury
Matthew F. Philips,Gustav Mattiasson,Tadeusz Wieloch,Anders Björklund,Barbro B. Johansson,Gregor Tomasevic,Alberto Martínez-Serrano,Philipp M. Lenzlinger,Grant Sinson,M. Sean Grady,Tracy K. McIntosh +10 more
TL;DR: It is demonstrated that immortalized neural stem cells that have been retrovirally transduced to produce NGF can markedly improve cognitive and neuromotor function and rescue hippocampal CA3 neurons when transplanted into the injured brain during the acute posttraumatic period.
Journal ArticleDOI
Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants.
TL;DR: It is proposed that intranigral striatal transplants, by a GABA-mediated inhibitory action, can reduce the overactivity of the host SN projection neurons and can induce significant recovery in complex motor behavior in the rat PD model and that such grafts may be used to increase the overall functional efficacy of intrastriatal VM grafts.
Journal ArticleDOI
Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts.
Hansjorg Sauer,Hansjorg Sauer,Walter Fischer,G Nikkhah,Stanley J. Wiegand,P. Brundin,Ronald M. Lindsay,Anders Björklund +7 more
TL;DR: Brain-derived neurotrophic factor has been shown to promote the survival of dopaminergic neurons from the substantia nigra in cell culture and in vivo, and grafted fetal nigral tissue to the dopamine-depleted striatum of 6-hydroxydopamine-lesioned rats receiving two-week intraventricular infusions or daily intrastriatal injections of BDNF, NGF, or vehicle.
Book
Neural transplantation : a practical approach
TL;DR: Staging and dissection of rat embryos, S.D. Lund and R.B. Dunnett grafting genetically modified cells within the rat CNS, and the use of peripheral nerve grafts to study CNS regeneration.