A
Anders Björklund
Researcher at Lund University
Publications - 771
Citations - 87172
Anders Björklund is an academic researcher from Lund University. The author has contributed to research in topics: Transplantation & Dopamine. The author has an hindex of 165, co-authored 769 publications receiving 84268 citations. Previous affiliations of Anders Björklund include University of Washington & Institute for the Study of Labor.
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Innervation of embryonic hippocampal implants by regenerating axons of cholinergic septal neurons in the adult rat
Lawrence F. Kromer,Lawrence F. Kromer,Anders Björklund,Anders Björklund,Ulf Stenevi,Ulf Stenevi +5 more
TL;DR: It is suggested that implants of a normal embryonic target tissue can promote axonal regeneration in mature neurons of the mammalian central nervous system and that some neurons in the adult mammalian CNS retain at least part of their embryonic capacity to generate axons and recognize specific postsynaptic targets in developing CNS tissue.
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Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
TL;DR: It is shown here that lack of Ngn2 impairs the development of mesDA neurons, such that less than half of the normal mesDA neuron number remain in Ngn1 mutant mice at postnatal stages.
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GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson’s disease
Mickael Decressac,Ayse Ulusoy,Bengt Mattsson,Biljana Georgievska,Marina Romero-Ramos,Deniz Kirik,Anders Björklund +6 more
TL;DR: Viral vector-mediated delivery of glial cell line-derived neurotrophic factor into substantia nigra and/or striatum was inefficient in preventing the wild-type α-synuclein-induced loss of dopamine neurons and terminals and did not ameliorate the behavioural deficit in this rat model of Parkinson's disease.
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Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats.
TL;DR: The results provide evidence that intrastriatal grafts of fetal striatal tissue receive extensive dopaminergic afferents from the host substantia nigra, and that they may be capable of establishing connections also with thalamus, neocortex and globus pallidus of the host, as well as with the spared portions of theHost caudate-putamen.
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Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain.
TL;DR: A large fraction of the grafted cells remained undifferentiated in a stem or progenitor cell stage as revealed by the expression of nestin and/or GFAP in the adult rat brain.