Anders Björklund

TL;DR: The prominent hypothalamic and thalamic dopamine and noradrenaline cell groups described in the present paper have hitherto been largely neglected and a more detailed neuro-anatomical knowledge of these neuronal systems should provide a basis for studies on their roles in diencephalic functions.

TL;DR: Data obtained in rodent and primate models of PD highlight the importance of how and where the factor is administered, supporting the view that GDNF has to be delivered locally in the brain parenchyma, at the receptive target site, to provide therapeutic benefit in PD patients.

TL;DR: Two patients with Parkinson’s disease, successfully treated with fetal tissue transplants more than a decade ago, developed troublesome involuntary movements, which were determined to be a result of an overabundance of serotonin-using neurons that developed from the graft, and strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease are suggested.

TL;DR: It is suggested that tirilazad mesylate may improve survival of grafted dopamine neurons in patients, which is in agreement with observations in experimental animals.

TL;DR: Because of its slow and protracted time-course and its ability to re-establish innervation also in initially denervated areas, this compensatory collateral sprouting phenomenon may be of particular interest for the understanding of the long-term, protracted functional recovery that is seen both after experimental brain lesions as well as in patients with severe brain injuries.