Anders Björklund

TL;DR: The present findings suggest that the full expression of dopamine‐receptor‐induced Fos activation and turning behaviour depends on an intact glutamatergic corticostriatal input.

TL;DR: In this article, septal suspension grafts were injected into the previously denervated hippocampal formation, and the activity of the grafted neurons was assessed by measurements of [14C]acetylcholine (ACh) synthesis from [14c]glucose in vitro.

TL;DR: It is shown that in vivo gene transfer of the DA-synthetic enzymes tyrosine hydroxylase and GTP cyclohydrolase 1 using recombinant adeno-associated virus vectors can provide a constant source of DOPA production locally in the striatum, at a level that is effective in reducing L-DOPA-induced dyskinesias by >85%, and reverse lesion-induced motor impairments.

TL;DR: The results show that surgical or pharmacological manipulations of the ascending brainstem monoaminergic systems, which innervate wide areas of the forebrain, including the septum and the hippocampal formation, have pronounced effects on septo-hippocampal cholinergic activity.

TL;DR: It is concluded that graft‐to‐host projections, running along and inside host myelinated bundles, are formed from intrastriatal striatal grafts within 1–2 weeks of implantation, consistent with previous work showing that outgrowing axons lose their M6 immunoreactivity as they mature and become myelination.