A
Andre E. Nel
Researcher at University of California, Los Angeles
Publications - 423
Citations - 62202
Andre E. Nel is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Paleontology. The author has an hindex of 105, co-authored 325 publications receiving 56090 citations. Previous affiliations of Andre E. Nel include Stellenbosch University & University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Journal ArticleDOI
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
Tian Xia,Michael Kovochich,Monty Liong,Lutz Mädler,Lutz Mädler,Benjamin Gilbert,Haibin Shi,Joanne I. Yeh,Jeffrey I. Zink,Andre E. Nel +9 more
TL;DR: The results demonstrate that metal oxide nanoparticles induce a range of biological responses that vary from cytotoxic to cytoprotective and can only be properly understood by using a tiered test strategy such as that developed for oxidative stress and adapted to study other aspects of nanoparticle toxicity.
Journal ArticleDOI
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage.
Ning Li,Constantinos Sioutas,Arthur K. Cho,Debra A. Schmitz,Chandan Misra,Joan M. Sempf,Meiying Wang,Terry D. Oberley,John R. Froines,Andre E. Nel +9 more
TL;DR: The studies demonstrate that the increased biological potency of UFPs is related to the content of redox cycling organic chemicals and their ability to damage mitochondria.
Journal ArticleDOI
Comparison of the Abilities of Ambient and Manufactured Nanoparticles To Induce Cellular Toxicity According to an Oxidative Stress Paradigm
Tian Xia,Michael Kovochich,Jonathan A. Brant,Matt Hotze,Joan M. Sempf,Terry Oberley,Constantinos Sioutas,Joanne I. Yeh,Mark R. Wiesner,Andre E. Nel +9 more
TL;DR: It is demonstrated that ROS generation and oxidative stress are a valid test paradigm to compare NP toxicity, and particle interactions with cellular components are capable of generating oxidative stress.