Anshul Kundaje

TL;DR: The strengths and limitations of biochemical, evolutionary, and genetic approaches for defining functional DNA segments, potential sources for the observed differences in estimated genomic coverage, and the biological implications of these discrepancies are reviewed.

TL;DR: WILDS is presented, a benchmark of in-the-wild distribution shifts spanning diverse data modalities and applications, and is hoped to encourage the development of general-purpose methods that are anchored to real-world distribution shifts and that work well across different applications and problem settings.

TL;DR: These methods rediscover and summarize diverse aspects of chromatin architecture, elucidate the interplay between chromatin activity and RNA transcription, and reveal that a large proportion of the genome lies in a quiescent state, even across multiple cell types.

TL;DR: In this paper, a Bayesian approach was used to define credible sets for the T1D-associated SNPs localized to enhancer sequences active in thymus, T and B cells, and CD34(+) stem cells.

TL;DR: DeepLIFT (Learning Important FeaTures), an efficient and effective method for computing importance scores in a neural network that compares the activation of each neuron to its 'reference activation' and assigns contribution scores according to the difference.