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Anshul Kundaje
Researcher at Stanford University
Publications - 252
Citations - 43164
Anshul Kundaje is an academic researcher from Stanford University. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 60, co-authored 203 publications receiving 32299 citations. Previous affiliations of Anshul Kundaje include Microsoft & Columbia University.
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Proceedings Article
Fourier-transform-based attribution priors improve the interpretability and stability of deep learning models for genomics
TL;DR: The Fourier transform of input-level attribution scores are computed at training-time, and high-frequency components of the Fourier spectrum are penalized to improve deep learning models’ stability, interpretability, and performance on held-out data, especially when training data is severely limited.
Posted ContentDOI
Size-independent mRNA synthesis and chromatin-based partitioning mechanisms generate and maintain constant amounts of protein per cell
Matthew P. Swaffer,Devon Chandler-Brown,Maurice Langhinrichs,Georgi K. Marinov,William J. Greenleaf,Anshul Kundaje,Kurt M. Schmoller,Jan M. Skotheim +7 more
TL;DR: During asymmetric division size-independent transcription is insufficient for size- Independent protein expression and chromatin-binding ensures equal amounts of protein are partitioned to unequally sized cells to maintain size- independent protein amounts.
Posted ContentDOI
Denoising genome-wide histone ChIP-seq with convolutional neural networks
TL;DR: Aconvolutional denoising algorithm, Coda, is introduced that uses convolutional neural networks to learn a mapping from suboptimal to high-quality histone ChIP-seq data, and has the potential to improve data quality at reduced costs.
Posted ContentDOI
Impact of the X chromosome and sex on regulatory variation
Kimberly R. Kukurba,Princy Parsana,Kevin S. Smith,Zachary Zappala,David A. Knowles,Marie-Julie Favé,Xin Li,Xiaowei Zhu,James B. Potash,Myrna M. Weissman,Jianxin Shi,Anshul Kundaje,Douglas F. Levinson,Philip Awadalla,Sara Mostafavi,Alexis Battle,Stephen B. Montgomery +16 more
TL;DR: An analysis of the impact of both sex and the X chromosome on patterns of gene expression identified through transcriptome sequencing of whole blood from 922 individuals identified that genes on the X chromosomes are more likely to have sex-specific expression compared to the autosomal genes.
Journal ArticleDOI
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Ceres Fernandez-Rozadilla,Maria Timofeeva,Zhishan Chen,Philip J. Law,Minta Thomas,Stephanie L. Schmit,Virginia Díez-Obrero,Li Hsu,Juan Fernández-Tajes,Claire Palles,Kitty Sherwood,Sarah Briggs,Victoria Svinti,K. Donnelly,Susan M. Farrington,James P. Blackmur,P G Vaughan-Shaw,Xiao-Ou Shu,Jirong Long,Qiuyin Cai,Xingyi Guo,Ying Chang Lu,Peter Broderick,James B. Studd,Jeroen R. Huyghe,Tabitha A. Harrison,David V. Conti,Christopher H. Dampier,Matt Devall,Fredrick R. Schumacher,Marilena Melas,Gad Rennert,Mireia Obón-Santacana,Vicente Martín Sánchez,Ferran Moratalla-Navarro,Jae Hwan Oh,Jeongseon Kim,Sun Ha Jee,Keum Ji Jung,Sun-Seog Kweon,Min-Ho Shin,Aesun Shin,Yoon Ok Ahn,Dong-Hyun Kim,Isao Oze,Wanqing Wen,Keitaro Matsuo,Koichi Matsuda,Chizu Tanikawa,Zefang Ren,Yu-Tang Gao,Wei Hua Jia,John L. Hopper,Mark A. Jenkins,Aung Ko Win,Rish K. Pai,Jane C. Figueiredo,Robert W. Haile,Steven Gallinger,Michael O. Woods,Polly A. Newcomb,David Duggan,Jeremy Peter Cheadle,Richard Kaplan,Tim Maughan,Rachel Kerr,David Kerr,Iva Kirac,Jan Böhm,Lukka-Pekka Mecklin,Pekka Jousilahti,Paul Knekt,Lauri A. Aaltonen,Harri Rissanen,Eero Pukkala,Johan Holmberg Eriksson,Tatiana Cajuso,Ulrika A. Hänninen,Johanna Kondelin,Kimmo Palin,Tomas Tanskanen,Laura Renkonen-Sinisalo,Brent W. Zanke,Satu Männistö,Demetrius Albanes,Stephanie J. Weinstein,Edward A. Ruiz-Narváez,Julie K. Palmer,C. D. Buchanan,Elizabeth Platz,Kala Visvanathan,Cornelia M. Ulrich,Erin M. Siegel,Stefanie Brezina,Andrea Gsur,Peter J. Campbell,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Martha L. Slattery,John D. Potter,Konstantinos K. Tsilidis,Mathias Schulze,Marc J. Gunter,Neil Murphy,A. Castells,Sergi Castellví-Bel,Leticia Moreira,Volker Arndt,Anna Shcherbina,Mariana C. Stern,Bens Pardamean,Timothy E. Bishop,Graham Blakemore Giles,Melissa C. Southey,Gregory Idos,Kevin McDonnell,Zomoroda Abu-Ful,Joel K. Greenson,Katerina Shulman,Flavio Lejbkowicz,Kenneth Offit,Robert S. Steinfelder,Temitope O. Keku,Bethany Van Guelpen,Thomas J. Hudson,Heather Hampel,Rachel Pearlman,Sonja I. Berndt,Richard H. Hayes,Marie Martinez,Sushma S. Thomas,Douglas A. Corley,Paul D.P. Pharoah,Susanna C. Larsson,Yun Yen,Heinz-Josef Lenz,Emily White,Li Xin Li,Kimberly F. Doheny,Elizabeth W. Pugh,Tameka Shelford,Andrew Chan,Marcia Cruz-Correa,Annika Lindblom,David J. Hunter,Amit Joshi,Clemens Schafmayer,Peter C. Scacheri,Anshul Kundaje,Deborah A. Nickerson,Robert Schoen,Jochen Hampe,Zsofia K. Stadler,Pavel Vodicka,Ludmila Vodickova,Veronika Vymetalkova,Nickolas Papadopoulos,Chistopher Edlund,W. James Gauderman,D. Thomas,David Shibata,Amanda E. Toland,Sanford D. Markowitz,Andre E. Kim,Stephen J. Chanock,Fränzel J.B. Van Duijnhoven,Edith F. Feskens,Lori C. Sakoda,Manuela Gago-Dominguez,Alicja Wolk,Alessio Naccarati,Barbara Pardini,Liesel M. FitzGerald,Soo-Chin Lee,Shuji Ogino,Stephanie A. Bien,Charles Kooperberg,Christopher Li,Yi-Kuei Lin,R Reid Prentice,Conghui Qu,Stéphane Bézieau,Catherine M. Tangen,Elaine R. Mardis,Taiki Yamaji,Norie Sawada,Motoki Iwasaki,Christopher A. Haiman,Loic Le Marchand,Anna C. Wu,Chenxu Qu,Caroline McNeil,Gerhard J. R. Coetzee,Caroline Hayward,I. A. Deary,Sarah Harris,Evropi Theodoratou,Stuart Reid,Marion Walker,Li-Yin Ooi,Victor Moreno,Graham Casey,Stephen B. Gruber,Ian Tomlinson,Wei Zheng,Malcolm G. Dunlop,Richard S. Houlston,Ulrike Peters +208 more
TL;DR: This article conducted a genome-wide association study meta-analysis of 100,204 colorectal cancer cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported.