A
Augustine Kong
Researcher at University of Oxford
Publications - 238
Citations - 96524
Augustine Kong is an academic researcher from University of Oxford. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 134, co-authored 237 publications receiving 89818 citations. Previous affiliations of Augustine Kong include University of Iceland & University of Chicago.
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Journal ArticleDOI
A common variant on chromosome 9p21 affects the risk of myocardial infarction
Anna Helgadottir,Gudmar Thorleifsson,Andrei Manolescu,Solveig Gretarsdottir,Thorarinn Blondal,Aslaug Jonasdottir,Abalbjorg Jonasdottir,Asgeir Sigurdsson,Adam Baker,Arnar Palsson,Gisli Masson,Daniel F. Gudbjartsson,Kristinn P. Magnusson,Karl Andersen,Allan I. Levey,Valgerdur M Backman,Sigurborg Matthiasdottir,Thorbjorg Jonsdottir,Stefan T Palsson,Helga Einarsdottir,Steinunn Gunnarsdottir,Arnaldur Gylfason,Viola Vaccarino,W. Craig Hooper,Muredach P. Reilly,Christopher B. Granger,Harland Austin,Daniel J. Rader,Svati H. Shah,Arshed A. Quyyumi,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +34 more
TL;DR: An association between myocardial infarction and a common sequence variant on chromosome 9p21 was associated with the disease with high significance and approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardious disease is 1.64 times as great as that of noncarriers.
Journal ArticleDOI
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.
Florian Zink,Simon N. Stacey,Gudmundur L. Norddahl,Michael L. Frigge,Olafur T. Magnusson,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorgeir E. Thorgeirsson,Asgeir Sigurdsson,Sigurjon A. Gudjonsson,Julius Gudmundsson,Jon G. Jonasson,Laufey Tryggvadottir,Thorvaldur Jonsson,Agnar Helgason,Arnaldur Gylfason,Patrick Sulem,Thorunn Rafnar,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Gisli Masson,Augustine Kong,Kari Stefansson,Kari Stefansson +25 more
TL;DR: It is found that CH is very common in the elderly, trending toward inevitability, and somatic mutations in TET2, DNMT3A, ASXL1, and PPM1D are associated with CH at high significance, however, known CD mutations were evident in only a fraction of CH cases.
Journal ArticleDOI
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
Agnar Helgason,Snæbjörn Pálsson,Snæbjörn Pálsson,Gudmar Thorleifsson,Struan F.A. Grant,Struan F.A. Grant,Valur Emilsson,Steinunn Gunnarsdottir,Adebowale Adeyemo,Yuanxiu Chen,Guanjie Chen,Inga Reynisdottir,Rafn Benediktsson,Anke Hinney,Torben Hansen,Gitte Andersen,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Helmut Schäfer,Mezbah U. Faruque,Ayo Doumatey,Jie Zhou,Robert L. Wilensky,Muredach P. Reilly,Daniel J. Rader,Yu Z. Bagger,Claus Christiansen,Gunnar Sigurdsson,Johannes Hebebrand,Oluf Pedersen,Oluf Pedersen,Unnur Thorsteinsdottir,Jeffrey R. Gulcher,Augustine Kong,Charles N. Rotimi,Kari Stefansson +36 more
TL;DR: Another variant of the TCF7L2 type 2 diabetes risk variant, HapBT2D, is identified that shows evidence of positive selection in East Asian, European and West African populations, indicating that the selective advantage of HapA may have been mediated through effects on energy metabolism.
Journal ArticleDOI
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer.
Simon N. Stacey,Andrei Manolescu,Patrick Sulem,Steinunn Thorlacius,Sigurjon A. Gudjonsson,Gudbjorn F. Jonsson,Margret Jakobsdottir,Jon Thor Bergthorsson,Julius Gudmundsson,Katja K.H. Aben,Luc J Strobbe,Dorine W. Swinkels,K. C. Anton van Engelenburg,Brian E. Henderson,Laurence N. Kolonel,Loic Le Marchand,Esther Millastre,Raquel Andrés,Berta Saez,J. Lambea,Javier Godino,E. Polo,Alejandro Tres,Simone Picelli,Johanna Rantala,Sara Margolin,Thorvaldur Jonsson,Helgi Sigurdsson,Thora Jonsdottir,Jon Hrafnkelsson,Jakob Johannsson,Thorarinn Sveinsson,Gardar Myrdal,Hlynur Niels Grimsson,Steinunn G Sveinsdottir,Kristin Alexiusdottir,Jona Saemundsdottir,Asgeir Sigurdsson,Jelena Kostic,Larus J. Gudmundsson,Kristleifur Kristjansson,Gisli Masson,James D. Fackenthal,Clement Adebamowo,Temidayo O. Ogundiran,Olufunmilayo I. Olopade,Christopher A. Haiman,Annika Lindblom,Jose I. Mayordomo,Lambertus A. Kiemeney,Jeffrey R. Gulcher,Thorunn Rafnar,Unnur Thorsteinsdottir,Oskar T. Johannsson,Augustine Kong,Kari Stefansson +55 more
TL;DR: A genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls identified two SNPs on 5p12 that confer risk, preferentially for ER-positive tumors.
Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
Cecilia M. Lindgren,Iris M. Heid,Joshua C. Randall,Claudia Lamina,Valgerdur Steinthorsdottir,Lu Qi,Elizabeth K. Speliotes,Gudmar Thorleifsson,Cristen J. Willer,Blanca M. Herrera,Anne U. Jackson,Noha Lim,Paul Scheet,Nicole Soranzo,Najaf Amin,Yurii S. Aulchenko,John C. Chambers,Alexander W. Drong,Jian'an Luan,Helen N. Lyon,Fernando Rivadeneira,Serena Sanna,Nicholas J. Timpson,M. Carola Zillikens,Jing Hua Zhao,Peter Almgren,Stefania Bandinelli,Amanda J. Bennett,Richard N. Bergman,Lori L. Bonnycastle,Suzannah Bumpstead,Stephen J. Chanock,Lynn Cherkas,Peter S. Chines,Lachlan J. M. Coin,Cyrus Cooper,Gabriel Crawford,Angela Doering,Anna F. Dominiczak,Alex S. F. Doney,Shah Ebrahim,Paul Elliott,Michael R. Erdos,Karol Estrada,Luigi Ferrucci,Guido Fischer,Nita G. Forouhi,Christian Gieger,Harald Grallert,Christopher J. Groves,Scott M. Grundy,Candace Guiducci,David Hadley,Anders Hamsten,Aki S. Havulinna,Albert Hofman,Rolf Holle,John W. Holloway,Thomas Illig,Bo Isomaa,Leonie C. Jacobs,Karen A. Jameson,Pekka Jousilahti,Fredrik Karpe,Johanna Kuusisto,Jaana Laitinen,G. Mark Lathrop,Debbie A Lawlor,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Mario A. Morken,Andrew P. Morris,Patricia B. Munroe,Narisu Narisu,Anna Nordström,Peter Nordström,Ben A. Oostra,Colin N. A. Palmer,Felicity Payne,John F. Peden,Inga Prokopenko,Frida Renström,Aimo Ruokonen,Veikko Salomaa,Manjinder S. Sandhu,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Kijoung Song,Xin Yuan,Heather M. Stringham,Amy J. Swift,Tiinamaija Tuomi,Manuela Uda,Peter Vollenweider,Gérard Waeber,Chris Wallace,G. Bragi Walters,Michael N. Weedon,Jacqueline C.M. Witteman,Cuilin Zhang,Weihua Zhang,Mark J. Caulfield,Francis S. Collins,George Davey Smith,Ian N.M. Day,Paul W. Franks,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Augustine Kong,Jaspal S. Kooner,Markku Laakso,Edward G. Lakatta,Vincent Mooser,Andrew D. Morris,Leena Peltonen,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Toshiko Tanaka,Jaakko Tuomilehto,André G. Uitterlinden,Cornelia M. van Duijn,Nicholas J. Wareham,Dawn M. Waterworth,Michael Boehnke,Panos Deloukas,Leif Groop,David J. Hunter,Unnur Thorsteinsdottir,David Schlessinger,H.-Erich Wichmann,Timothy M. Frayling,Gonçalo R. Abecasis,Joel N. Hirschhorn,Ruth J. F. Loos,Kari Stefansson,Karen L. Mohlke,Inês Barroso +140 more
TL;DR: Vandervell Foundation and Wellcome Trust (068545/Z/02, GR072960 as discussed by the authors, GR076113, GR069224, GR086596/Z /08/Z)