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Augustine Kong
Researcher at University of Oxford
Publications - 238
Citations - 96524
Augustine Kong is an academic researcher from University of Oxford. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 134, co-authored 237 publications receiving 89818 citations. Previous affiliations of Augustine Kong include University of Iceland & University of Chicago.
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Journal ArticleDOI
A sequence variant on 17q21 is associated with age at onset and severity of asthma
Eva Halapi,Daniel F. Gudbjartsson,Gudrun M. Jonsdottir,Unnur S. Bjornsdottir,Unnur S. Bjornsdottir,Gudmar Thorleifsson,Hafdis T. Helgadottir,Carolyn Williams,Gerard H. Koppelman,Andrea Heinzmann,H. Marike Boezen,Aslaug Jonasdottir,Thorarinn Blondal,Sigurjon A. Gudjonsson,Adalbjorg Jonasdottir,Theodora Thorlacius,Amanda P. Henry,Janine Altmueller,Marcus Krueger,Hyoung Doo Shin,Soo-Taek Uh,Hyun Sub Cheong,Brynja Jonsdottir,Bjorn R. Ludviksson,Dora Ludviksdottir,David Gislason,Choon-Sik Park,Klaus A. Deichmann,Philip J. Thompson,Matthias Wjst,Ian P. Hall,Dirkje S. Postma,Thorarinn Gislason,Augustine Kong,Ingileif Jonsdottir,Ingileif Jonsdottir,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +39 more
TL;DR: The contribution of rs7216389-T to the development of asthma is unlikely to operate only through an impact on the expression of ORMDL3 or GSDMB genes, as other sequence variants showing a weaker association with asthma compared with that of rs 7216389 were more strongly associated with the expression with both genes.
Journal ArticleDOI
A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration
Hannes Helgason,Hannes Helgason,Patrick Sulem,Maheswara R Duvvari,Hongrong Luo,Gudmar Thorleifsson,Hreinn Stefansson,Ingileif Jonsdottir,Ingileif Jonsdottir,Gisli Masson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,G. Bragi Walters,Olafur T. Magnusson,Augustine Kong,Augustine Kong,Thorunn Rafnar,Lambertus A. Kiemeney,Frederieke E. Schoenmaker-Koller,Ling Zhao,Camiel J. F. Boon,Yaojun Song,Sascha Fauser,Michelle Pei,Tina Ristau,Shirrina Patel,Sandra Liakopoulos,Johannes P. H. van de Ven,Carel B. Hoyng,Henry Ferreyra,Yaou Duan,Paul S. Bernstein,Asbjorg Geirsdottir,Gudleif Helgadottir,Einar Stefánsson,Anneke I. den Hollander,Kang Zhang,Fridbert Jonasson,Haraldur Sigurdsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +42 more
TL;DR: Through whole-genome sequencing of 2,230 Icelanders, a rare nonsynonymous SNP is detected in the C3 gene encoding a p.Lys155Gln substitution in complement factor 3, potentially creating resistance to inhibition by this factor and predicted to result in enhanced complement activation.
Journal ArticleDOI
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31
Unnur Styrkarsdottir,Gudmar Thorleifsson,Hafdis T. Helgadottir,Nils Bomer,Sarah Metrustry,S.M.A. Bierma-Zeinstra,Annelieke M Strijbosch,Evangelos Evangelou,Evangelos Evangelou,Deborah J. Hart,Marian Beekman,Aslaug Jonasdottir,Asgeir Sigurdsson,Finnur F. Eiriksson,Margret Thorsteinsdottir,Michael L. Frigge,Augustine Kong,Sigurjon A. Gudjonsson,Olafur T. Magnusson,Gisli Masson,Albert Hofman,Nigel K Arden,Thorvaldur Ingvarsson,Stefan Lohmander,Margreet Kloppenburg,Fernando Rivadeneira,Rob G H H Nelissen,Tim D. Spector,André G. Uitterlinden,P. Eline Slagboom,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Ingileif Jonsdottir,Ingileif Jonsdottir,Ana M. Valdes,Ana M. Valdes,Ingrid Meulenbelt,Joyce B. J. van Meurs,Helgi Jonsson,Kari Stefansson,Kari Stefansson +40 more
TL;DR: A genome-wide association study in subjects with severe hand osteoarthritis, using variants identified through the whole-genome sequencing of 2,230 Icelanders, found two significantly associated loci in the Icelandic discovery set: at 15q22 and 1p31, both within the ALDH1A2 gene.
Journal ArticleDOI
A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24
Hakon Hakonarson,Unnur S. Bjornsdottir,Eva Halapi,Snæbjörn Pálsson,Elva Adalsteinsdottir,David Gislason,Gudmundur Finnbogason,Thorarinn Gislason,Kristleifur Kristjansson,Thor Arnason,Illugi Birkisson,Michael L. Frigge,Augustine Kong,Jeffrey R. Gulcher,Kari Stefansson +14 more
TL;DR: Results provide evidence of a novel susceptibility gene for asthma on chromosome 14q24, identified by cross-matching a list of patients with asthma with a genealogy database of the entire Icelandic nation and naming it "asthma locus one" (AS1).
Journal ArticleDOI
The genetic spectrum of a population-based sample of familial hemiplegic migraine
LL Thomsen,M. Kirchmann,Asgeir Björnsson,Hreinn Stefansson,R. M. Jensen,A. C. Fasquel,H. Petursson,M. Stefansson,Mike Frigge,Augustine Kong,Jeff Gulcher,Kari Stefansson,Jes Olesen +12 more
TL;DR: It is shown that only 14% of FHM families in the general Danish population have exonic FHM mutations in the CACNA1A or ATP1A2 gene, which may reflect less bias in FHM family ascertainment and/or more locus heterogeneity than described previously.