A
Augustine Kong
Researcher at University of Oxford
Publications - 238
Citations - 96524
Augustine Kong is an academic researcher from University of Oxford. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 134, co-authored 237 publications receiving 89818 citations. Previous affiliations of Augustine Kong include University of Iceland & University of Chicago.
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Journal ArticleDOI
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
Kerrin S. Small,Åsa K. Hedman,Elin Grundberg,Alexandra C. Nica,Gudmar Thorleifsson,Augustine Kong,Unnur Thorsteindottir,Unnur Thorsteindottir,So-Youn Shin,Hannah B. Richards,Nicole Soranzo,Nicole Soranzo,Kourosh R. Ahmadi,Cecilia M. Lindgren,Kari Stefansson,Emmanouil T. Dermitzakis,Panos Deloukas,Tim D. Spector,Mark I. McCarthy +18 more
TL;DR: It is shown that the type 2 diabetes and high-density lipoprotein cholesterol–associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression.
Journal ArticleDOI
Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
Robert Power,Stacy Steinberg,Gyda Bjornsdottir,Cornelius A. Rietveld,Abdel Abdellaoui,Michel M Nivard,Magnus Johannesson,Tessel E. Galesloot,Jouke J. Hottenga,Gonneke Willemsen,David Cesarini,Daniel J. Benjamin,Patrik K. E. Magnusson,Fredrik Ullén,Henning Tiemeier,Albert Hofman,Frank J. A. van Rooij,G. Bragi Walters,Engilbert Sigurdsson,Thorgeir E. Thorgeirsson,Andres Ingason,Agnar Helgason,Augustine Kong,Lambertus A. Kiemeney,Philipp Koellinger,Dorret I. Boomsma,Daniel F. Gudbjartsson,Hreinn Stefansson,Kari Stefansson +28 more
TL;DR: Creativity and psychosis share genetic roots, and higher polygenic risk scores for schizophrenia and bipolar disorder would predict creativity could not be accounted for by increased relatedness between creative individuals and those with psychoses.
Journal ArticleDOI
New common variants affecting susceptibility to basal cell carcinoma
Simon N. Stacey,Patrick Sulem,Gisli Masson,Sigurjon A. Gudjonsson,Gudmar Thorleifsson,Margret Jakobsdottir,Asgeir Sigurdsson,Daniel F. Gudbjartsson,Bardur Sigurgeirsson,Kristrun R. Benediktsdottir,Kristin Thorisdottir,Rafn Ragnarsson,Dominique Scherer,Kari Hemminki,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Rafael Botella-Estrada,Virtudes Soriano,Pablo Juberías,Berta Saez,Yolanda Gilaberte,Victoria Fuentelsaz,Cristina Corredera,Matilde Grasa,Veronica Höiom,Annika Lindblom,Johannes J. Bonenkamp,Michelle M. van Rossum,Katja K H Aben,Esther de Vries,Mario Santinami,Maria G Di Mauro,Andrea Maurichi,Judith Wendt,Pia Hochleitner,Hubert Pehamberger,Julius Gudmundsson,Droplaug N Magnusdottir,Solveig Gretarsdottir,Hilma Holm,Valgerdur Steinthorsdottir,Michael L. Frigge,Thorarinn Blondal,Jona Saemundsdottir,Hjordis Bjarnason,Kristleifur Kristjansson,Gyda Bjornsdottir,Ichiro Okamoto,Licia Rivoltini,Monica Rodolfo,Lambertus A. Kiemeney,Johan Hansson,Eduardo Nagore,Jose I. Mayordomo,Rajesh Kumar,Margaret R. Karagas,Heather H. Nelson,Jeffrey R Gulcher,Thorunn Rafnar,Unnur Thorsteinsdottir,Jón Ólafsson,Augustine Kong,Kari Stefansson +63 more
TL;DR: It is reported conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma.
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A direct characterization of human mutation based on microsatellites
James Sun,Agnar Helgason,Agnar Helgason,Gisli Masson,Sigríđur Sunna Ebenesersdóttir,Heng Li,Heng Li,Swapan Mallick,Sante Gnerre,Nick Patterson,Augustine Kong,David Reich,David Reich,Kari Stefansson,Kari Stefansson +14 more
TL;DR: The largest study of new mutations to date, comprising 2,058 germline changes discovered by analyzing 85,289 Icelanders at 2,477 microsatellites, infer that the sequence mutation rate is 1.4–2.3 × 10−8 mutations per base pair per generation (90% credible interval) and that human-chimpanzee speciation occurred 3.7–6.6 million years ago.
Journal ArticleDOI
A rare variant in MYH6 is associated with high risk of sick sinus syndrome
Hilma Holm,Daniel F. Gudbjartsson,Patrick Sulem,Gisli Masson,Hafdis T. Helgadottir,Carlo Zanon,Olafur T. Magnusson,Agnar Helgason,Jona Saemundsdottir,Arnaldur Gylfason,Hrafnhildur Stefansdottir,Solveig Gretarsdottir,Stefan E Matthiasson,Gu∂mundur Thorgeirsson,Aslaug Jonasdottir,Asgeir Sigurdsson,Hreinn Stefansson,Thomas Werge,Thorunn Rafnar,Lambertus A. Kiemeney,Babar Parvez,Raafia Muhammad,Dan M. Roden,Dawood Darbar,Gudmar Thorleifsson,G. Bragi Walters,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,David O. Arnar,Kari Stefansson,Kari Stefansson +31 more
TL;DR: A previously unidentified sick sinus syndrome susceptibility gene, MYH6, encoding the alpha heavy chain subunit of cardiac myosin is discovered through complementary application of SNP genotyping, whole-genome sequencing and imputation in 38,384 Icelanders.