A
Augustine Kong
Researcher at University of Oxford
Publications - 238
Citations - 96524
Augustine Kong is an academic researcher from University of Oxford. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 134, co-authored 237 publications receiving 89818 citations. Previous affiliations of Augustine Kong include University of Iceland & University of Chicago.
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Richard Karlsson Linnér,Pietro Biroli,Edward Kong,Fleur Meddens,Robbee Wedow,Mark Alan Fontana,Mael Lebreton,Stephen P. Tino,Abdel Abdellaoui,Anke R. Hammerschlag,Michel G. Nivard,Aysu Okbay,Cornelius A. Rietveld,Pascal N. Timshel,Maciej Trzaskowski,Ronald de Vlaming,Christian L. Zund,Yanchun Bao,Laura Buzdugan,Ann H. Caplin,Chia-Yen Chen,Peter Eibich,Pierre Fontanillas,Juan R. González,Peter K. Joshi,Ville Karhunen,Aaron Kleinman,Remy Z. Levin,Christina M. Lill,Gerardus A. Meddens,Gerard Muntané,Sandra Sanchez-Roige,Frank J. A. van Rooij,Erdogan Taskesen,Yang Wu,Futao Zhang,Michelle Agee,Babak Alipanahi,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Nicholas A. Furlotte,Karen E. Huber,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Joanna L. Mountain,Carrie A.M. Northover,Steven J. Pitts,J. Fah Sathirapongsasuti,Olga V. Sazonova,Janie F. Shelton,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,Vladimir Vacic,Catherine H. Wilson,Mawusse Agbessi,Habibul Ahsan,Isabel Alves,Anand Kumar Andiappan,Philip Awadalla,Alexis Battle,Frank Beutner,Marc Jan Bonder,Dorret I. Boomsma,Mark W. Christiansen,Annique Claringbould,Patrick Deelen,Tõnu Esko,Marie-Julie Favé,Lude Franke,Timothy M. Frayling,Sina A. Gharib,Gregory Gibson,Bastiaan T. Heijmans,Gibran Hemani,Rick Jansen,Mika Kähönen,Anette Kalnapenkis,Silva Kasela,Johannes Kettunen,Yungil Kim,Holger Kirsten,Peter Kovacs,Knut Krohn,Jaanika Kronberg-Guzman,Viktorija Kukushkina,Zoltán Kutalik,Bernett Lee,Terho Lehtimäki,Markus Loeffler,Urko M. Marigorta,Andres Metspalu,Lili Milani,Grant W. Montgomery,Martina Mueller-Nurasyid,Matthias Nauck,Brenda W.J.H. Penninx,Markus Perola,Natalia Pervjakova,Brandon L. Pierce,Joseph E. Powell,Holger Prokisch,Bruce M. Psaty,Olli T. Raitakari,Susan M. Ring,Samuli Ripatti,Olaf Rotzchke,Sina Rüeger,Ashis Saha,Markus Scholz,Katharina Schramm,Ilkka Seppälä,Michael Stumvoll,Patrick Sullivan,Peter-Bramt Hoen,Alexander Teumer,Joachim Thiery,Lin Tong,Anke Tönjes,Jenny van Dongen,Joyce B. J. van Meurs,Joost Verlouw,Peter M. Visscher,Uwe Voelker,Urmo Võsa,Harm-Jan Westra,Hanieh Yaghootkar,Jian Yang,Biao Zeng,James J. Lee,Tune H. Pers,Patrick Turley,Guo-Bo Chen,Valur Emilsson,Sven Oskarsson,Joseph K. Pickrell,Kevin Thom,Pascal Timshel,Tarunveer S. Ahluwalia,Jonas Bacelis,Clemens Baumbach,Gyda Bjornsdottir,Johannes H. Brandsma,Maria Pina Concas,Jaime Derringer,Tessel E. Galesloot,Giorgia Girotto,Richa Gupta,Leanne M. Hall,Sarah E. Harris,Edith Hofer,Momoko Horikoshi,Jennifer E. Huffman,Kadri Kaasik,Ioanna P. Kalafati,Augustine Kong,Jari Lahti,Sven J. van der Lee,Christiaan de Leeuw,Penelope A. Lind,Karl-Oskar Lindgren,Tian Liu,Massimo Mangino,Jonathan Marten,Evelin Mihailov,Michael B. Miller,Peter J. van der Most,Christopher Oldmeadow,Antony Payton,Wouter J. Peyrot,Yong Qian,Rico Rueedi,Erika Salvi,Boerge Schmidt,Katharina E. Schraut,Jianxin Shi,Albert V. Smith,Raymond A. Poot,Beate St Pourcain,Gudmar Thorleifsson,Niek Verweij,Dragana Vuckovic,Juergen Wellmann,Jingyun Yang,Wei Zhao,Zhihong Zhu,Behrooz Z. Alizadeh,Najaf Amin,Andrew Bakshi,Sebastian E. Baumeister,Ginevra Biino,Klaus Bønnelykke,Patricia A. Boyle,Harry Campbell,Francesco P. Cappuccio,Gail Davies,Jan-Emmanuel De Neve,Panos Deloukas,Ilja Demuth,Jun Ding,Lewin Eisele,Niina Eklund,David M. Evans,Jessica D. Faul,Mary F. Feitosa,Andreas J. Forstner,Ilaria Gandin,Bjarni Gunnarsson,Bjarni V. Halldorsson,Tamara B. Harris,Andrew Heath,Lynne J. Hocking,Elizabeth G. Holliday,Georg Homuth,Michael A. Horan,Jouke-Jan Hottenga,Philip L. De Jager,Astanand Jugessur,Marika Kaakinen,Stavroula Kanoni,Liisa Keltigangas-Jarvinen,Lambertus A. Kiemeney,Ivana Kolcic,Seppo Koskinen,Aldi T. Kraja,Martin Kroh,Antti Latvala,Lenore J. Launer,Maël Lebreton,Douglas F. Levinson,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Anu Loukola,Pamela A. F. Madden,Reedik Mägi,Tomi Mäki-Opas,Riccardo E. Marioni,Pedro Marques-Vidal,George McMahon,Christa Meisinger,Thomas Meitinger,Y. Milaneschi,Ronny Myhre,Christopher P. Nelson,Dale R. Nyholt,William E R Ollier,Aarno Palotie,Lavinia Paternoster,Nancy L. Pedersen,K. Petrovic,David J. Porteous,Katri Räikkönen,S M Ring,Antonietta Robino,Olga Rostapshova,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Alan R. Sanders,Antti-Pekka Sarin,Helena Schmidt,Rodney J. Scott,Blair H. Smith,Jennifer A. Smith,Jan A. Staessen,Elisabeth Steinhagen-Thiessen,Konstantin Strauch,Antonio Terracciano,Martin D. Tobin,Sheila Ulivi,Simona Vaccargiu,Lydia Quaye,Cristina Venturini,Anna A. E. Vinkhuyzen,Henry Voelzke,Judith M. Vonk,Diego Vozzi,Johannes Waage,Erin B. Ware,Gonneke Willemsen,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Hans Bisgaard,Ingrid B. Borecki,Ute Bültmann,Christopher F. Chabris,Francesco Cucca,Daniele Cusi,J. Deary,George Dedoussis,Cornelia M. van Duijn,Johan G. Eriksson,Barbara Franke,Paolo Gasparini,Pablo V. Gejman,Christian Gieger,Hans-Joergen Grabe,Jacob Gratten,Vilmundur Gudnason,Pim van der Harst,Caroline Hayward,David A. Hinds,Wolfgang Hoffmann,Elina Hyppönen,William G. Iacono,Bo Jacobsson,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Sharon L.R. Kardia,Steven F. Lehrer,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Neil Pendleton,Nicola Pirastu,Mario Pirastu,Ozren Polasek,Danielle Posthuma,Christine Power,Michael A. Province,Nilesh J. Samani,David Schlessinger,Reinhold E. Schmidt,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Veronique Vitart,Peter Vollenweider,David R. Weir,James F. Wilson,Alan F. Wright,Dalton Conley,Robert F. Krueger,George Davey Smith,David Laibson,Sarah E. Medland,Magnus Johannesson,Philipp Koellinger,David Cesarini,Daniel J. Benjamin,Adam Auton,Jason D. Boardman,David W. Clark,Andrew Conlin,Conor C. Dolan,Urs Fischbacher,Patrick J. F. Groenen,Kathleen Mullan Harris,Gregor Hasler,Albert Hofman,Mohammad Arfan Ikram,Sonia Jain,Robert Karlsson,Ronald C. Kessler,Maarten Kooyman,James MacKillop,Minna Männikkö,Carlos Morcillo-Suarez,Matthew B. McQueen,Klaus M. Schmidt,Melissa C. Smart,Matthias Sutter,Jon White,Harriet de Wit,Ernst Fehr,Meena Kumari,David Laibson,Michelle N. Meyer,Arcadi Navarro,Abraham A. Palmer,Daniel Schunk,Murray B. Stein,Rauli Svento,Paul R. H. J. Timmers,Robert J. Ursano,Gert G. Wagner,Jonathan P. Beauchamp +387 more
TL;DR: A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.
Journal ArticleDOI
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
Lambertus A. Kiemeney,Patrick Sulem,Søren Besenbacher,Sita H. Vermeulen,Asgeir Sigurdsson,Gudmar Thorleifsson,Daniel F. Gudbjartsson,Simon N. Stacey,Julius Gudmundsson,Carlo Zanon,Jelena Kostic,Gisli Masson,Hjordis Bjarnason,Stefan T Palsson,Oskar B Skarphedinsson,Sigurjon A. Gudjonsson,J. Alfred Witjes,Anne J. Grotenhuis,Gerald W. Verhaegh,D. Timothy Bishop,Sei C. Sak,Ananya Choudhury,Faye Elliott,Jennifer H. Barrett,Carolyn D. Hurst,Petra J. de Verdier,Charlotta Ryk,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Paolo Vineis,Paolo Vineis,Silvia Polidoro,Silvia Polidoro,Simonetta Guarrera,Simonetta Guarrera,Carlotta Sacerdote,Marcello Campagna,Donatella Placidi,Cecilia Arici,Maurice P. Zeegers,Maurice P. Zeegers,Eliane Kellen,Berta Saez Gutierrez,José I Sanz-Velez,Manuel Sanchez-Zalabardo,Gabriel Valdivia,Maria D. Garcia-Prats,Jan G. Hengstler,Meinolf Blaszkewicz,Holger Dietrich,Roel A. Ophoff,Roel A. Ophoff,Leonard H. van den Berg,Kristin Alexiusdottir,Kristleifur Kristjansson,Gudmundur Geirsson,Sigfus Nikulasson,Vigdis Petursdottir,Augustine Kong,Thorgeir E. Thorgeirsson,N. Aydin Mungan,Annika Lindblom,Michael A. van Es,Stefano Porru,Frank Buntinx,Frank Buntinx,Klaus Golka,Jose I. Mayordomo,Rajesh Kumar,Giuseppe Matullo,Giuseppe Matullo,Gunnar Steineck,Gunnar Steineck,Anne E. Kiltie,Katja K H Aben,Eirikur Jonsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Margaret A. Knowles,Thorunn Rafnar,Kari Stefansson,Kari Stefansson +82 more
TL;DR: The results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC, and Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low- grade stage Ta tumors.
Journal ArticleDOI
Genetic correction of PSA values using sequence variants associated with PSA levels.
Julius Gudmundsson,Søren Besenbacher,Patrick Sulem,Daniel F. Gudbjartsson,Isleifur Olafsson,Sturla Arinbjarnarson,Bjarni A. Agnarsson,Kristrun R. Benediktsdottir,Helgi J Isaksson,Jelena Kostic,Sigurjon A. Gudjonsson,Simon N. Stacey,Arnaldur Gylfason,Asgeir Sigurdsson,Hilma Holm,Unnur S. Bjornsdottir,Gudmundur I. Eyjolfsson,Sebastian Navarrete,Fernando Fuertes,Maria D. Garcia-Prats,E. Polo,Ionel Alexandru Checherita,Mariana Jinga,Paula Badea,Katja K.H. Aben,Jack A. Schalken,Inge M. van Oort,Fred C.G.J. Sweep,Brian T. Helfand,Michael Davis,Jenny L Donovan,Freddie C. Hamdy,Kristleifur Kristjansson,Jeffrey R. Gulcher,Gisli Masson,Augustine Kong,William J. Catalona,Jose I. Mayordomo,Gudmundur Geirsson,Gudmundur V. Einarsson,Rosa B. Barkardottir,Eirikur Jonsson,Viorel Jinga,Dana Mates,Lambertus A. Kiemeney,David E. Neal,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Thorunn Rafnar,Kari Stefansson,Kari Stefansson +50 more
TL;DR: The authors suggest that a personalized PSA cutoff value, based on genotype, should be used when deciding to perform a biopsy to improve the predictive accuracy of the test and to ensure that only men who need a prostate biopsy are subjected to this procedure.
Journal ArticleDOI
Expanding the range of ZNF804A variants conferring risk of psychosis
Stacy Steinberg,Ole Mors,Anders D. Børglum,Anders D. Børglum,Omar Gustafsson,Omar Gustafsson,Thomas Werge,Preben Bo Mortensen,Ole A. Andreassen,Engilbert Sigurdsson,Thorgeir E. Thorgeirsson,Yvonne Böttcher,Pall I. Olason,Roel A. Ophoff,Roel A. Ophoff,Sven Cichon,Iris H Gudjonsdottir,Olli Pietiläinen,Olli Pietiläinen,Mette Nyegaard,Annamari Tuulio-Henriksson,Andres Ingason,Thomas Hansen,Lavinia Athanasiu,Jaana Suvisaari,Jan-Erik Lönnqvist,Tiina Paunio,Annette M. Hartmann,Gesche Jürgens,Merete Nordentoft,David M. Hougaard,Bent Nørgaard-Pedersen,René Breuer,H.-J. Möller,Ina Giegling,Birte Glenthøj,Henrik B. Rasmussen,M. Mattheisen,István Bitter,János Réthelyi,Thordur Sigmundsson,Ragnheidur Fossdal,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Mirella Ruggeri,Sarah Tosato,Eric Strengman,Lambertus A. Kiemeney,Ingrid Melle,Srdjan Djurovic,Lilia I. Abramova,Kaleda Vg,Muriel Walshe,Elvira Bramon,Evangelos Vassos,Tao Li,Tao Li,Gillian Fraser,Neil Walker,Timothea Toulopoulou,J. Yoon,Nelson B. Freimer,Rita M. Cantor,Robin M. Murray,Augustine Kong,Vera Golimbet,Erik G. Jönsson,Lars Terenius,Ingrid Agartz,Hannes Petursson,Markus M. Nöthen,M. Rietschel,Leena Peltonen,Leena Peltonen,Dan Rujescu,David A. Collier,David A. Collier,Hreinn Stefansson,D St Clair,Kari Stefansson,Kari Stefansson +80 more
TL;DR: As it has been proposed that variants such as rs1344706[T]—common and with low relative risk—may also serve to identify regions harboring less common, higher-risk susceptibility alleles, ZNF804A is searched for large copy number variants (CNVs) in psychosis patients and patients with other psychiatric disorders and 39 481 controls.
Journal ArticleDOI
Graphical templates for model registration
Yali Amit,Augustine Kong +1 more
TL;DR: This combination of local operators to describe points of interest/landmarks and a graph to describe their geometric orientation in the plane, yields fast and precise matches of the model to the data, with no initialization required.