C
Chris J.L.M. Meijer
Researcher at VU University Amsterdam
Publications - 745
Citations - 83366
Chris J.L.M. Meijer is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Cervical cancer & Cervical intraepithelial neoplasia. The author has an hindex of 128, co-authored 733 publications receiving 78705 citations. Previous affiliations of Chris J.L.M. Meijer include VU University Medical Center & Academic Center for Dentistry Amsterdam.
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Journal ArticleDOI
Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear.
M A E Nobbenhuis,Theo J.M. Helmerhorst,Adriaan J. C. van den Brule,Lawrence Rozendaal,Feja J. Voorhorst,P. Dick Bezemer,René H.M. Verheijen,Chris J.L.M. Meijer +7 more
TL;DR: It is found that high- risk HPV clearance preceded regression of cervical lesions by an average of 3 months, and retesting of high-risk HPV after 6 months in women with mild to moderate dyskaryosis predicts cytological regression.
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Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer
Saskia M. Wilting,Robert A.A. van Boerdonk,Florianne E. Henken,Chris J.L.M. Meijer,Begoña Diosdado,Gerrit A. Meijer,Carlos le Sage,Reuven Agami,Peter J.F. Snijders,Renske D.M. Steenbergen +9 more
TL;DR: DNA methylation-based silencing of hsa-miR-124 is functionally involved in cervical carcinogenesis and may provide a valuable marker for improved detection of cervical cancer and its high-grade precursor lesions.
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The natural course of asymptomatic Chlamydia trachomatis infections: 45% clearance and no development of clinical PID after one-year follow-up.
Servaas A. Morré,Adriaan J. C. van den Brule,Lawrence Rozendaal,A Joan P Boeke,Feja J. Voorhorst,Sjoerd de Blok,Chris J.L.M. Meijer +6 more
TL;DR: The findings showed that almost half of the asymptomatic C. trachomatis infections in women cleared during one year of follow-up and none developed clinical pelvic inflammatory disease (PID), which is a much lower figure than previously suggested.
Journal ArticleDOI
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer
Agustín F. Fernández,Cecilia Rosales,Pilar López-Nieva,Osvaldo Graña,Esteban Ballestar,Santiago Ropero,Jesús Espada,Sonia A. Melo,Amaia Lujambio,Mario F. Fraga,Irene Pino,Biola M. Javierre,Francisco J. Carmona,Francesco Acquadro,Renske D.M. Steenbergen,Peter J.F. Snijders,Chris J.L.M. Meijer,Pascal Pineau,Anne Dejean,Belen Lloveras,Gabriel Capellá,Josep Quer,Maria Buti,Juan Lgnacio Esteban,Helena Allende,Francisco Rodriguez-Frias,Xavier Castellsagué,Janos Minarovits,Jordi Ponce,Daniela Capello,Gianluca Gaidano,Juan C. Cigudosa,Gonzalo Gómez-López,David G. Pisano,Alfonso Valencia,Miguel A. Piris,Francesc Bosch,Ellen Cahir-McFarland,Elliott Kieff,Manel Esteller +39 more
TL;DR: The DNA methylomes presented provide evidence of the dynamic nature of the epigenome in contrast to the genome, and it is observed that the DNA methylome of these viruses evolves from an unmethylated to a highly methylated genome in association with the progression of the disease.
Journal ArticleDOI
EBV-positive gastric adenocarcinomas: a distinct clinicopathologic entity with a low frequency of lymph node involvement.
Josine van Beek,Axel zur Hausen,Elma Meershoek – Klein Kranenbarg,Cornelis J.H. van de Velde,Jaap M. Middeldorp,Adriaan J. C. van den Brule,Chris J.L.M. Meijer,Elisabeth Bloemena +7 more
TL;DR: EBV-carrying gastric adenocarcinomas are a distinct entity of carcinomas, characterized not only by unique genomic aberrations, but also by distinct clinicopathologic features associated with significantly better prognosis.