Chris Sander

TL;DR: These studies show that miR-122, a 22-nucleotide microRNA, is derived from a liver-specific non-coding polyadenylated RNA transcribed from the gene hcr, which may be a specific mRNA target, CAT-1, which is expressed in all mammaliantissues but with lower levels in adult liver.

TL;DR: To reduce redundancy in the Protein Data Bank of 3D protein structures, which is caused by many homologous proteins in the data bank, a representative set of structures is selected to reduce time and effort in statistical analyses.

TL;DR: A systematic comparison of 23 Ig domain structures with less than 25% pairwise residue identity was performed using automatic structural alignment and analysis of beta-sheet and loop topology, revealing a common structural core of only four beta-strands and four different topological subtypes that correlate with the length of the intervening sequence between strands c and e, the most variable region in sequence.

TL;DR: These data support a model of tumorigenesis whereby PDTCs and ATCs arise from well-differentiated tumors through the accumulation of key additional genetic abnormalities, many of which have prognostic and possible therapeutic relevance.

TL;DR: A new method for modelling protein dynamics using normal-mode analysis in internal co-ordinates, particularly well suited for modelling collective motion, makes possible direct visualization of biologically interesting modes, and is complementary to the more time-consuming simulation of molecular dynamics trajectories.