Chris Sander

TL;DR: An integromic analysis of gene alterations that modulate transforming growth factor β-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas provides a broad molecular perspective relevant for future functional and therapeutic studies of the diverse cancer pathways mediated by the TGF-β superfamily.

TL;DR: Clinical observations of glucose uptake with a pathologic and molecular subtype of human breast cancer are linked and related approaches to derive molecular determinants of radiotracer retention for other PET-imaging probes are suggested.

TL;DR: Analysis of miRNA involvement in the phenotypic expression and regulation of oncogenic PDGF signaling found that miR-34a is downregulated by PDGF pathway activation in vitro, and analysis of data from the Cancer Genome Atlas revealed that miGlioblastoma expression is significantly lower in proneural gliomas compared to other tumor subtypes.

TL;DR: Re-expression vectors or selective agents directed at miR-143 or its targets may have therapeutic value in dedifferentiated liposarcoma, and treatment with a PLK1 inhibitor potently induced G(2)-M growth arrest and apoptosis in liposARcoma cells.

TL;DR: Eight protein crystal structures, which have been refined against X-ray diffraction data extending to atomic resolution, 1.2 A or better, were inspected using four different validation tools, PROCHECK, PROVE, SQUID and WHATCHECK.