Chris Sander

TL;DR: This hybrid "EC-NMR" method, developed using NMR data for several soluble proteins and validated by comparison with corresponding reference structures determined by X-ray crystallography and/or conventional NMR methods, has significant potential for analysis of protein structures from solid-state N MR data and for studies of integral membrane proteins.

TL;DR: In this paper, the authors used unbiased mass spectrometry based proteomics with data-driven protein network analysis to systematically characterize how HGSOC cells respond to PARP1i treatment.

TL;DR: Using a novel protein sequence comparison method, it is found that there are similarities between different Nef sequences and the α chain of human MHC class I proteins.

TL;DR: The method REFLECT (REcurrent Features Leveraged for Combination Therapies), which integrates machine learning and cancer informatics algorithms, generates a precision therapy resource matching 2,201 drug combinations to co-alteration signatures across 201 cohorts stratified from 10,392 patients and 33 cancer types.

TL;DR: The complete DNA sequence of cosmid clone 31A5 containing a 35 452 bp segment from the left arm of chromosome IV from Saccharomyces cerevisiae, was determined from an ordered set of subclones in combination with primer walking on the cosmid.