Ciarán Fisher

TL;DR: The history of the AOP concept and its most prominent strengths are discussed, including the advantages of a formalized approach, the systematic collection of weight of evidence, the linkage of mechanisms to apical end points, the examination of the plausibility of epidemiological data, the identification of critical knowledge gaps and the design of mechanistic test methods.

TL;DR: This white paper outlines a general read-across assessment concept using NAMs to support hazard characterization of the grouped compounds by generating data on their dynamic and kinetic properties and outlines how mechanistic knowledge such as adverse outcome pathways (AOPs) can be utilized.

TL;DR: In women, abdominal obesity is a major driver of hepatic large VLDL particle secretion, whereas postmenopausal status was characterized by increased small V LDL particle size, which provides a mechanistic basis for the hyperlipidemia observed in post menopausal obesity.

TL;DR: In this article, the authors review the mechanisms by which test chemicals distribute between in vitro assay compartments, and also list the physicochemical properties driving the extent of this distribution, and explain the makeup of mass balance models that estimate free concentrations and cell-associated concentrations in in vitro toxicity assays.

TL;DR: The first dynamic simulations including regulatory mechanisms and a genome-scale metabolic network in human cell are presented, using bile acid homeostasis in human hepatocytes as a case study.