B
Barbara Zdrazil
Researcher at University of Vienna
Publications - 55
Citations - 959
Barbara Zdrazil is an academic researcher from University of Vienna. The author has contributed to research in topics: Computer science & Docking (molecular). The author has an hindex of 13, co-authored 47 publications receiving 715 citations. Previous affiliations of Barbara Zdrazil include University of Düsseldorf & University of Göttingen.
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Journal ArticleDOI
Adverse outcome pathways: opportunities, limitations and open questions.
Marcel Leist,Ahmed Ghallab,Ahmed Ghallab,Rabea Graepel,Rosemarie Marchan,Reham Hassan,Reham Hassan,Susanne Hougaard Bennekou,Alice Limonciel,Mathieu Vinken,Stefan Schildknecht,Tanja Waldmann,Erik H.J. Danen,Ben van Ravenzwaay,Hennicke Kamp,Iain Gardner,Patricio Godoy,Frédéric Y. Bois,Albert Braeuning,Raymond Reif,Franz Oesch,Dirk Drasdo,Dirk Drasdo,Stefan Höhme,Michael Schwarz,Thomas Hartung,Thomas Braunbeck,Joost B. Beltman,Harry Vrieling,Ferran Sanz,Anna Forsby,Anna Forsby,Domenico Gadaleta,Ciarán Fisher,Jens M. Kelm,David A. Fluri,Gerhard F. Ecker,Barbara Zdrazil,Andrea Terron,Paul Jennings,Bart van der Burg,Steven Dooley,Annemarie H. Meijer,Egon Willighagen,Egon Willighagen,Marvin Martens,Chris T. Evelo,Chris T. Evelo,Enrico Mombelli,Olivier Taboureau,Olivier Taboureau,Alberto Mantovani,Barry Hardy,Bjørn E. V. Koch,Sylvia Escher,Christoph van Thriel,Cristina Cadenas,Dinant Kroese,Bob van de Water,Jan G. Hengstler +59 more
TL;DR: The history of the AOP concept and its most prominent strengths are discussed, including the advantages of a formalized approach, the systematic collection of weight of evidence, the linkage of mechanisms to apical end points, the examination of the plausibility of epidemiological data, the identification of critical knowledge gaps and the design of mechanistic test methods.
Journal ArticleDOI
The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines
Sonja Sucic,Stefan Dallinger,Barbara Zdrazil,René Weissensteiner,Trine Nygaard Jørgensen,Marion Holy,Oliver Kudlacek,Stefan Seidel,Joo Hee Cha,Ulrik Gether,Amy Hauck Newman,Gerhard F. Ecker,Michael Freissmuth,Harald H. Sitte +13 more
TL;DR: It is concluded that the N terminus of monoamine transporters acts as a lever that sustains reverse transport.
Journal ArticleDOI
Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project.
Sylvia Escher,Hennicke Kamp,Susanne Hougaard Bennekou,Annette Bitsch,Ciarán Fisher,Rabea Graepel,Jan G. Hengstler,Matthias Herzler,Derek Knight,Marcel Leist,Ulf Norinder,Gladys Ouedraogo,Manuel Pastor,Sharon B. Stuard,Andrew White,Barbara Zdrazil,Bob van de Water,Dinant Kroese +17 more
TL;DR: This white paper outlines a general read-across assessment concept using NAMs to support hazard characterization of the grouped compounds by generating data on their dynamic and kinetic properties and outlines how mechanistic knowledge such as adverse outcome pathways (AOPs) can be utilized.
Journal ArticleDOI
Scientific competency questions as the basis for semantically enriched open pharmacological space development
Kamal Azzaoui,Edgar Jacoby,Stefan Senger,Emiliano Cuadrado Rodríguez,Mabel Loza,Barbara Zdrazil,Marta Pinto,Antony J. Williams,Victor De La Torre,Jordi Mestres,Manuel Pastor,Olivier Taboureau,Matthias Rarey,Christine Chichester,Steve Pettifer,Niklas Blomberg,Lee Harland,Bryn Williams-Jones,Gerhard F. Ecker +18 more
TL;DR: The scientific requirements identified by the Innovative Medicines Initiative (IMI) Open PHACTS consortium for the design of an open pharmacological space (OPS) information system are outlined and typical scientific competency questions provided by the consortium members are analyzed.
Journal ArticleDOI
The Rise and Fall of a Scaffold: A Trend Analysis of Scaffolds in the Medicinal Chemistry Literature
Barbara Zdrazil,Rajarshi Guha +1 more
TL;DR: Trend analyses of scaffold properties could support scaffold selection and prioritization in small molecule development projects and explain why a scaffold receives more attention over time.