Rabea Graepel

TL;DR: The history of the AOP concept and its most prominent strengths are discussed, including the advantages of a formalized approach, the systematic collection of weight of evidence, the linkage of mechanisms to apical end points, the examination of the plausibility of epidemiological data, the identification of critical knowledge gaps and the design of mechanistic test methods.

TL;DR: Evidence suggests that endogenous activation of peripheral TRPA1 receptors plays a critical role in the development of TNFα-induced mechanical hyperalgesia and in sustaining the mechanical hyperAlgesia observed after intraaarticular injection of CFA.

TL;DR: TRPA1 is involved in mediating vasodilation and can also influence changes in blood pressure of possible relevance to autonomic system reflexes and potentially to vasovagal/neurocardiogenic syncope disorders.

TL;DR: TRPA1 acts as a primary vascular cold sensor, as determined through TRPA1 pharmacological antagonism or gene deletion, by using a murine model of local environmental cold exposure to show a new understanding of the importance of TRpa1 in cold exposure.

TL;DR: A notable effect of H2O2 is demonstrated in mediating inflammatory hyperalgesia, thus highlighting H 2O2 removal as a novel therapeutic target for anti‐hyperalgesic drugs in the clinic.