Megan Crow

TL;DR: It is discovered that cardinal GABAergic neuron types are delineated by a transcriptional architecture that encodes their synaptic communication patterns and forms a multi-layered molecular scaffold along the cell membrane that may customize synaptic connectivity patterns and input-output signaling properties.

TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.

TL;DR: This study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps, and establishes a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.

TL;DR: This work develops MetaNeighbor for measuring cell-type replication across datasets, and uses it to identify marker genes for neuron subtypes with evidence of replication, and finds that large sets of variably expressed genes can identify replicable cell types with high accuracy.

TL;DR: Data support a role for histone acetylation in the emergence of neuropathic pain and suggest that this effect may be mediated at the level of the spinal cord through inhibition of HDAC1 function.