C
Cornelia Brendel
Researcher at University of Marburg
Publications - 70
Citations - 3200
Cornelia Brendel is an academic researcher from University of Marburg. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 24, co-authored 64 publications receiving 2685 citations. Previous affiliations of Cornelia Brendel include University Hospital of Giessen and Marburg.
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Journal ArticleDOI
Diverse Applications of Nanomedicine
Beatriz Pelaz,Christoph Alexiou,Ramon A. Alvarez-Puebla,Frauke Alves,Frauke Alves,Anne M. Andrews,Sumaira Ashraf,Lajos P. Balogh,Laura Ballerini,Alessandra Bestetti,Cornelia Brendel,Susanna Bosi,Mónica Carril,Warren C. W. Chan,Chunying Chen,Xiaodong Chen,Xiaoyuan Chen,Zhen Cheng,Daxiang Cui,Jianzhong Du,Christian Dullin,Alberto Escudero,Alberto Escudero,Neus Feliu,Mingyuan Gao,Michael D. George,Yury Gogotsi,Arnold Grünweller,Zhongwei Gu,Naomi J. Halas,Norbert Hampp,Roland K. Hartmann,Mark C. Hersam,Patrick Hunziker,Ji Jian,Xingyu Jiang,Philipp Jungebluth,Pranav Kadhiresan,Kazunori Kataoka,Ali Khademhosseini,Jindřich Kopeček,Nicholas A. Kotov,Harald F. Krug,Dong Soo Lee,Claus-Michael Lehr,Kam W. Leong,Xing-Jie Liang,Mei Ling Lim,Luis M. Liz-Marzán,Xiaowei Ma,Paolo Macchiarini,Huan Meng,Helmuth Möhwald,Paul Mulvaney,Andre E. Nel,Shuming Nie,Peter Nordlander,Teruo Okano,Jose Oliveira,Tai Hyun Park,Reginald M. Penner,Maurizio Prato,Maurizio Prato,Víctor F. Puntes,Vincent M. Rotello,Amila Samarakoon,Raymond E. Schaak,Youqing Shen,Sebastian Sjöqvist,Andre G. Skirtach,Andre G. Skirtach,Mahmoud Soliman,Molly M. Stevens,Hsing-Wen Sung,Ben Zhong Tang,Rainer Tietze,Buddhisha Udugama,J. Scott VanEpps,Tanja Weil,Tanja Weil,Paul S. Weiss,Itamar Willner,Yuzhou Wu,Yuzhou Wu,Lily Yang,Zhao Yue,Qian Zhang,Qiang Zhang,Xian-En Zhang,Yuliang Zhao,Xin Zhou,Wolfgang J. Parak +91 more
TL;DR: An overview of recent developments in nanomedicine is provided and the current challenges and upcoming opportunities for the field are highlighted and translation to the clinic is highlighted.
Journal ArticleDOI
Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells
Cornelia Brendel,C Scharenberg,Marius Dohse,Robert W. Robey,Susan E. Bates,Suneet Shukla,Suresh V. Ambudkar,Ying Wang,Gunther Wennemuth,Gunther Wennemuth,Andreas Burchert,U Boudriot,Andreas Neubauer +12 more
TL;DR: Evidence is suggested for the role of ABC transporters in resistance to TKI on primitive HSCs and CML stem cells and provides a rationale how TKI resistance can be overcome in vivo.
Journal ArticleDOI
Comparison of ATP-Binding Cassette Transporter Interactions with the Tyrosine Kinase Inhibitors Imatinib, Nilotinib, and Dasatinib
Marius Dohse,Christian Scharenberg,Suneet Shukla,Robert W. Robey,Thorsten Volkmann,John F. Deeken,Cornelia Brendel,Suresh V. Ambudkar,Andreas Neubauer,Susan E. Bates +9 more
TL;DR: The results suggest that therapeutic doses of imatinib and nilotinib may diminish the potential of ABCB1 and ABCG2 to limit oral absorption or confer resistance, and the hypothesis that all three TKIs are substrates of ABC transporters is supported.
Journal ArticleDOI
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
Nadine Bollig,Anne Brüstle,Kerstin Kellner,Waltraud Ackermann,Elfadil Abass,Hartmann Raifer,Bärbel Camara,Cornelia Brendel,Gavin Giel,Evita Bothur,Magdalena Huber,Christoph Paul,Alexandra Elli,Richard A. Kroczek,Roza Nurieva,Chen Dong,Ralf Jacob,Tak W. Mak,Tak W. Mak,Michael Lohoff +19 more
TL;DR: The transcription factor IRF4 is identified as a T-cell intrinsic precondition for TFH cell differentiation and GC formation and placed in the center of antibody production toward T- cell–dependent antigens.
Journal ArticleDOI
Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation
Ying Wang,Dali Cai,Cornelia Brendel,Christine Barett,Philipp Erben,Paul W. Manley,Andreas Hochhaus,Andreas Neubauer,Andreas Burchert +8 more
TL;DR: Adaptive autocrine secretion of GM-CSF mediates BCR/ABL-independent IM and NI resistance via activation of the antiapoptotic Jak-2/STAT-5 pathway, providing a rationale for the application of JAK-2 inhibitors to eradicate residual disease in CML.