F
Felix Luessi
Researcher at University of Mainz
Publications - 85
Citations - 3259
Felix Luessi is an academic researcher from University of Mainz. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 23, co-authored 70 publications receiving 2517 citations. Previous affiliations of Felix Luessi include Montreal Neurological Institute and Hospital & Technische Universität München.
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Journal ArticleDOI
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Ashley Beecham,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Dionysia K. Xifara,Mary F. Davis,Anu Kemppinen,Chris Cotsapas,Chris Cotsapas,Tejas S. Shah,Chris C. A. Spencer,David R. Booth,An Goris,Annette Bang Oturai,Janna Saarela,Bertrand Fontaine,Bernhard Hemmer,C. Martin,Frauke Zipp,Sandra D'Alfonso,Filippo Martinelli-Boneschi,Bruce V. Taylor,Hanne F. Harbo,Ingrid Kockum,Jan Hillert,Tomas Olsson,Maria Ban,Jorge R. Oksenberg,Rogier Q. Hintzen,Lisa F. Barcellos,Lisa F. Barcellos,Lisa F. Barcellos,Cristina Agliardi,Lars Alfredsson,Mehdi Alizadeh,Carl A. Anderson,Robert Andrews,Helle Bach Søndergaard,Amie Baker,Gavin Band,Sergio E. Baranzini,Nadia Barizzone,Jeffrey C. Barrett,Céline Bellenguez,Laura Bergamaschi,Luisa Bernardinelli,Achim Berthele,Viola Biberacher,Thomas M.C. Binder,Hannah Blackburn,Izaura Lima Bomfim,Paola Brambilla,Simon Broadley,Bruno Brochet,Lou Brundin,Dorothea Buck,Helmut Butzkueven,Helmut Butzkueven,Stacy J. Caillier,William Camu,Wassila Carpentier,Paola Cavalla,Elisabeth Gulowsen Celius,Irene Coman,Giancarlo Comi,Lucia Corrado,Leentje Cosemans,Isabelle Cournu-Rebeix,Bruce A.C. Cree,Daniele Cusi,Vincent Damotte,Gilles Defer,Silvia Delgado,Panos Deloukas,Alessia Di Sapio,Alexander T. Dilthey,Peter Donnelly,Bénédicte Dubois,Martin Duddy,Sarah Edkins,Irina Elovaara,Federica Esposito,Nikos Evangelou,Barnaby Fiddes,Judith Field,Andre Franke,Colin Freeman,Irene Y. Frohlich,Daniela Galimberti,Christian Gieger,Pierre-Antoine Gourraud,Christiane Graetz,Andrew Graham,Verena Grummel,Clara Guaschino,Athena Hadjixenofontos,Hakon Hakonarson,Christopher Halfpenny,Gillian L Hall,Per Hall,Anders Hamsten,James Harley,Timothy Harrower,Clive Hawkins,Garrett Hellenthal,Charles Hillier,Jeremy Hobart,M.-M. Hoshi,Sarah E. Hunt,Maja Jagodic,Ilijas Jelcic,Ilijas Jelcic,Angela Jochim,B. E. Kendall,Allan G. Kermode,Allan G. Kermode,Trevor J. Kilpatrick,Keijo Koivisto,Ioanna Konidari,Thomas Korn,Helena C. Kronsbein,Cordelia Langford,Malin Larsson,Mark Lathrop,Mark Lathrop,Christine Lebrun-Frenay,Jeannette Lechner-Scott,Michelle Lee,Maurizio Leone,Virpi Leppa,Giuseppe Liberatore,Benedicte A. Lie,Christina M. Lill,Christina M. Lill,Magdalena Lindén,Jenny Link,Felix Luessi,Jan Lycke,Fabio Macciardi,Fabio Macciardi,Satu Männistö,Clara P. Manrique,Roland Martin,Roland Martin,Vittorio Martinelli,Deborah F. Mason,Gordon Mazibrada,Cristin McCabe,Inger Lise Mero,Julia Y Mescheriakova,Loukas Moutsianas,Kjell-Morten Myhr,Guy Nagels,Richard Nicholas,Petra Nilsson,Fredrik Piehl,Matti Pirinen,Siân Price,Hong Quach,Mauri Reunanen,Wim Robberecht,Neil Robertson,Mariaemma Rodegher,David Rog,Marco Salvetti,Nathalie Schnetz-Boutaud,Finn Sellebjerg,Rebecca C. Selter,Catherine Schaefer,Sandip Shaunak,Ling Shen,Simon Shields,Volker Siffrin,Mark Slee,Per Soelberg Sørensen,Melissa Sorosina,Mireia Sospedra,Mireia Sospedra,Anne Spurkland,Amy Strange,Emilie Sundqvist,Vincent Thijs,J W Thorpe,Anna Ticca,Pentti J. Tienari,Cornelia M. van Duijn,Elizabeth Visser,Steve Vucic,Helga Westerlind,James S. Wiley,Alastair Wilkins,James F. Wilson,Juliane Winkelmann,John Zajicek,Eva Zindler,Jonathan L. Haines,Margaret A. Pericak-Vance,Adrian J. Ivinson,Graeme J. Stewart,David A. Hafler,David A. Hafler,Stephen L. Hauser,Alastair Compston,Gil McVean,Philip L. De Jager,Philip L. De Jager,Stephen Sawcer,Jacob L. McCauley +206 more
TL;DR: This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Ashley Beecham,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Dionysia K. Xifara,Mary F. Davis,Anu Kemppinen,Chris Cotsapas,Chris Cotsapas,Tejas S. Shah,Chris C. A. Spencer,David R. Booth,An Goris,Annette Bang Oturai,Janna Saarela,Bertrand Fontaine,Bernhard Hemmer,C. Martin,Frauke Zipp,Sandra D'Alfonso,Filippo Martinelli-Boneschi,Bruce V. Taylor,Hanne F. Harbo,Ingrid Kockum,Jan Hillert,Tomas Olsson,Maria Ban,Jorge R. Oksenberg,Rogier Q. Hintzen,Lisa F. Barcellos,Lisa F. Barcellos,Lisa F. Barcellos,Cristina Agliardi,Lars Alfredsson,Mehdi Alizadeh,Carl A. Anderson,Robert Andrews,Helle Bach Søndergaard,Amie Baker,Gavin Band,Sergio E. Baranzini,Nadia Barizzone,Jeffrey C. Barrett,Céline Bellenguez,Laura Bergamaschi,Luisa Bernardinelli,Achim Berthele,Viola Biberacher,Thomas M.C. Binder,Hannah Blackburn,Izaura Lima Bomfim,Paola Brambilla,Simon Broadley,Bruno Brochet,Lou Brundin,Dorothea Buck,Helmut Butzkueven,Helmut Butzkueven,Stacy J. Caillier,William Camu,Wassila Carpentier,Paola Cavalla,Elisabeth Gulowsen Celius,Irene Coman,Giancarlo Comi,Lucia Corrado,Leentje Cosemans,Isabelle Cournu-Rebeix,Bruce A.C. Cree,Daniele Cusi,Vincent Damotte,Gilles Defer,Silvia Delgado,Panos Deloukas,Alessia Di Sapio,Alexander T. Dilthey,Peter Donnelly,Bénédicte Dubois,Martin Duddy,Sarah Edkins,Irina Elovaara,Federica Esposito,Nikos Evangelou,Barnaby Fiddes,Judith Field,Andre Franke,Colin Freeman,Irene Y. Frohlich,Daniela Galimberti,Christian Gieger,Pierre-Antoine Gourraud,Christiane Graetz,Andrew Graham,Verena Grummel,Clara Guaschino,Athena Hadjixenofontos,Hakon Hakonarson,Christopher Halfpenny,Gillian L Hall,Per Hall,Anders Hamsten,James Harley,Timothy Harrower,Clive Hawkins,Garrett Hellenthal,Charles Hillier,Jeremy Hobart,M.-M. Hoshi,Sarah E. Hunt,Maja Jagodic,Ilijas Jelcic,Ilijas Jelcic,Angela Jochim,B. E. Kendall,Allan G. Kermode,Allan G. Kermode,Trevor J. Kilpatrick,Keijo Koivisto,Ioanna Konidari,Thomas Korn,Helena C. Kronsbein,Cordelia Langford,Malin Larsson,Mark Lathrop,Mark Lathrop,Christine Lebrun-Frenay,Jeannette Lechner-Scott,Michelle Lee,Maurizio Leone,Virpi Leppa,Giuseppe Liberatore,Benedicte A. Lie,Christina M. Lill,Christina M. Lill,Magdalena Lindén,Jenny Link,Felix Luessi,Jan Lycke,Fabio Macciardi,Fabio Macciardi,Satu Männistö,Clara P. Manrique,Roland Martin,Roland Martin,Vittorio Martinelli,Deborah F. Mason,Gordon Mazibrada,Cristin McCabe,Inger Lise Mero,Julia Y Mescheriakova,Loukas Moutsianas,Kjell-Morten Myhr,Guy Nagels,Richard Nicholas,Petra Nilsson,Fredrik Piehl,Matti Pirinen,Siân Price,Hong Quach,Mauri Reunanen,Wim Robberecht,Neil Robertson,Mariaemma Rodegher,David Rog,Marco Salvetti,Nathalie Schnetz-Boutaud,Finn Sellebjerg,Rebecca C. Selter,Catherine Schaefer,Sandip Shaunak,Ling Shen,Simon Shields,Volker Siffrin,Mark Slee,Per Soelberg Sørensen,Melissa Sorosina,Mireia Sospedra,Mireia Sospedra,Anne Spurkland,Amy Strange,Emilie Sundqvist,Vincent Thijs,J W Thorpe,Anna Ticca,Pentti J. Tienari,Cornelia M. van Duijn,Elizabeth Visser,Steve Vucic,Helga Westerlind,James S. Wiley,Alastair Wilkins,James F. Wilson,Juliane Winkelmann,John Zajicek,Eva Zindler,Jonathan L. Haines,Margaret A. Pericak-Vance,Adrian J. Ivinson,Graeme J. Stewart,David A. Hafler,David A. Hafler,Stephen L. Hauser,Alastair Compston,Gil McVean,Philip L. De Jager,Philip L. De Jager,Stephen Sawcer,Jacob L. McCauley +206 more
TL;DR: Using the ImmunoChip custom genotyping array, this article analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)).
Journal ArticleDOI
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation
Till F. M. Andlauer,Dorothea Buck,Gisela Antony,Antonios Bayas,Lukas Bechmann,Lukas Bechmann,Achim Berthele,Andrew T. Chan,Andrew T. Chan,Christiane Gasperi,Ralf Gold,Christiane Graetz,Jürgen Haas,Michael Hecker,Carmen Infante-Duarte,M. Knop,Tania Kümpfel,Volker Limmroth,Ralf A. Linker,Verena Loleit,Felix Luessi,Sven G. Meuth,Mark Mühlau,S. Nischwitz,Friedemann Paul,Michael Pütz,Tobias Ruck,Anke Salmen,Anke Salmen,Martin Stangel,Jan-Patrick Stellmann,Klarissa Hanja Stürner,Björn Tackenberg,Florian Then Bergh,Hayrettin Tumani,Clemens Warnke,Frank Weber,Frank Weber,Heinz Wiendl,Brigitte Wildemann,Uwe K. Zettl,Ulf Ziemann,Frauke Zipp,Janine Arloth,Peter Weber,Milena Radivojkov-Blagojevic,Markus O. Scheinhardt,Theresa Dankowski,Thomas Bettecken,Peter Lichtner,Darina Czamara,Tania Carrillo-Roa,Elisabeth B. Binder,Elisabeth B. Binder,Klaus Berger,Lars Bertram,Lars Bertram,Andre Franke,Christian Gieger,Stefan Herms,Stefan Herms,Georg Homuth,Marcus Ising,Karl-Heinz Jöckel,Tim Kacprowski,Stefan Kloiber,Matthias Laudes,Wolfgang Lieb,Christina M. Lill,Christina M. Lill,Susanne Lucae,Thomas Meitinger,Susanne Moebus,Martina Müller-Nurasyid,Markus M. Nöthen,Astrid Petersmann,Rajesh Rawal,Ulf Schminke,Konstantin Strauch,Henry Völzke,Melanie Waldenberger,Jürgen Wellmann,Eleonora Porcu,Antonella Mulas,Maristella Pitzalis,Carlo Sidore,Ilenia Zara,Francesco Cucca,Magdalena Zoledziewska,Andreas Ziegler,Andreas Ziegler,Bernhard Hemmer,Bertram Müller-Myhsok,Bertram Müller-Myhsok +93 more
TL;DR: A genome-wide association study on multiple sclerosis susceptibility in German cohorts with 4888 cases and 10,395 controls detected associations not found in larger, more heterogeneous cohorts, thus providing new clues regarding MS pathogenesis.
Journal ArticleDOI
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk
Mitja Mitrovic,Nikolaos A. Patsopoulos,Ashley Beecham,Theresa Dankowski,An Goris,Bénédicte Dubois,Marie B. D'hooghe,Robin Lemmens,Philip Van Damme,Helle Bach Søndergaard,Finn Sellebjerg,Per Soelberg Sørensen,Henrik Ullum,Lise Wegner Thoerner,Thomas Werge,Janna Saarela,Isabelle Cournu-Rebeix,Vincent Damotte,Bertrand Fontaine,Lena Guillot-Noel,Mark Lathrop,Sandra Vukusik,Pierre-Antoine Gourraud,Till F. M. Andlauer,Viola Pongratz,Dorothea Buck,Christiane Gasperi,Antonios Bayas,Christoph Heesen,Tania Kümpfel,Ralf A. Linker,Friedemann Paul,Martin Stangel,Björn Tackenberg,Florian Then Bergh,Clemens Warnke,Heinz Wiendl,Brigitte Wildemann,Uwe K. Zettl,Ulf Ziemann,Hayrettin Tumani,Ralf Gold,Verena Grummel,Bernhard Hemmer,Benjamin Knier,Christina M. Lill,Felix Luessi,Efthimios Dardiotis,Cristina Agliardi,Nadia Barizzone,Elisabetta Mascia,Luisa Bernardinelli,Giancarlo Comi,Daniele Cusi,Federica Esposito,Laura Ferrè,Cristoforo Comi,Daniela Galimberti,Maurizio Leone,Melissa Sorosina,Julia Y Mescheriakova,Rogier Q. Hintzen,Cornelia M. van Duijn,Charlotte E. Teunissen,Steffan D. Bos,Kjell-Morten Myhr,Elisabeth Gulowsen Celius,Benedicte A. Lie,Anne Spurkland,Manuel Comabella,Xavier Montalban,Lars Alfredsson,Pernilla Stridh,Jan Hillert,Maja Jagodic,Fredrik Piehl,Ilijas Jelcic,Roland Martin,Mireia Sospedra,Maria Ban,Clive Hawkins,Pirro G. Hysi,Seema Kalra,Fredrik Karpe,Jyoti Khadake,Genevieve Lachance,Matt J. Neville,Adam Santaniello,Stacy J. Caillier,Peter A. Calabresi,Bruce A.C. Cree,Anne H. Cross,Mary F. Davis,Jonathan L. Haines,Paul I.W. de Bakker,Silvia Delgado,Marieme Dembele,Keith R. Edwards,Kathryn C. Fitzgerald,Hakon Hakonarson,Ioanna Konidari,Ellen Lathi,Clara P. Manrique,Margaret A. Pericak-Vance,Laura Piccio,Cathy Schaefer,Cristin McCabe,Howard L. Weiner,Jacqueline I. Goldstein,Tomas Olsson,Georgios M. Hadjigeorgiou,Bruce V. Taylor,Lotti Tajouri,Jac Charlesworth,David R. Booth,Hanne F. Harbo,Adrian J. Ivinson,Stephen L. Hauser,Alastair Compston,Graeme Stewart,Frauke Zipp,Lisa F. Barcellos,Sergio E. Baranzini,Filippo Martinelli-Boneschi,Sandra D'Alfonso,Andreas Ziegler,Annette Bang Oturai,Jacob L. McCauley,Stephen Sawcer,Jorge R. Oksenberg,Philip L. De Jager,Ingrid Kockum,David A. Hafler,Chris Cotsapas +133 more
TL;DR: This work identifies four novel genes driving MS risk independently of common-variant signals, highlighting key pathogenic roles for regulatory T cell homeostasis and regulation, IFNγ biology, and NFκB signaling.
Posted ContentDOI
The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility
Nikolaos A. Patsopoulos,Sergio E. Baranzini,Adam Santaniello,Shoostari P,Chris Cotsapas,Wong G,Ashley Beecham,Tojo James,Replogle J,Ioannis S. Vlachos,Cristin McCabe,Tune H. Pers,Brandes A,Charles C. White,Brendan T. Keenan,Maria Cimpean,Winn P,Panteliadis I,Robbins A,Till F. M. Andlauer,Zarzycki O,Bénédicte Dubois,An Goris,Helle Bach Søndergaard,Finn Sellebjerg,Per Soelberg Sørensen,Henrik Ullum,Thoerner Lw,Janna Saarela,Rebeix Ic,Damotte,Bertrand Fontaine,Noel Lg,Mark Lathrop,Sandra Vukusik,Achim Berthele,Biberacher,Dorothea Buck,Christiane Gasperi,Christiane Graetz,Grummel,B. Hemmer,M.-M. Hoshi,Benjamin Knier,Thomas Korn,Christina M. Lill,Felix Luessi,Mark Mühlau,Frauke Zipp,Efthimios Dardiotis,Cristina Agliardi,Amoroso A,Nadia Barizzone,Benedetti M,Luisa Bernardinelli,Paola Cavalla,Ferdinando Clarelli,G. Comi,Daniele Cusi,Federica Esposito,Laura Ferrè,Daniela Galimberti,Clara Guaschino,Maurizio Leone,Martinelli,Moiola L,Marco Salvetti,Melissa Sorosina,Domizia Vecchio,Andrea Zauli,Silvia Santoro,Zuccalà M,Julia Y Mescheriakova,Duijn Cv,Steffan D. Bos,Elisabeth Gulowsen Celius,Anne Spurkland,Manuel Comabella,Xavier Montalban,Lars Alfredsson,Izaura Lima Bomfim,David Gomez-Cabrero,Jan Hillert,Maja Jagodic,M Lindén,Fredrik Piehl,Ilijas Jelcic,Roland Martin,Mireia Sospedra,Amie Baker,Maria Ban,Clive Hawkins,Hysi P,Seema Kalra,Fredrik Karpe,Jyoti Khadake,Genevieve Lachance,Molyneux P,Megan C Neville,J W Thorpe,Elizabeth M. Bradshaw,Stacy J. Caillier,Peter A. Calabresi,B. Cree,Anne H. Cross,Mary F. Davis,Bakker Pd,Silvia Delgado,Marieme Dembele,Keith R Edwards,Kathryn C. Fitzgerald,Frohlich I,Pierre-Antoine F. D. Gourraud,Jonathan L. Haines,Hakon Hakonarson,Dorlan J. Kimbrough,Noriko Isobe,Ioanna Konidari,Ellen Lathi,Marcus C. S. Lee,Taibo Li,An D,Zimmer A,Lo A,Lohith Madireddy,Clara P. Manrique,Mitja Mitrovic,Marta Olah,Ellis Patrick,Margaret A. Pericak-Vance,Laura Piccio,Cathy Schaefer,Howard L. Weiner,Kasper Lage,A Compston,David A. Hafler,Hanne F. Harbo,Stephen L. Hauser,Graeme J. Stewart,Sandra D'Alfonso,Giorgos M. Hadjigeorgiou,Bruce V. Taylor,Lisa F. Barcellos,David R. Booth,Rogier Q. Hintzen,Ingrid Kockum,Filippo Martinelli-Boneschi,Jacob L. McCauley,Jorge R. Oksenberg,Annette Bang Oturai,Stephen Sawcer,Ivinson A,Tommy Olsson,Phil De Jager,Murray L. Barclay,Laurent Peyrin-Biroulet,Mathias Chamaillard,Colombe J,Cottone M,Croft A,Renata D'Incà,Jonas Halfvarson,Hanigan K,Paul Henderson,Paul Henderson,Jean-Pierre Hugot,Jean-Pierre Hugot,Karban A,Nicholas A. Kennedy,Khan Ma,Marc Lémann,Arie Levine,Massey D,Monica Milla,Grant W. Montgomery,Evelyn Ng Sm,I. Oikonomou,Harald Peeters,Deborah D. Proctor,Jean-François Rahier,Roberts R,Paul Rutgeerts,Frank Seibold,Stronati L,Taylor Km,Törkvist L,Ublick K,Johan Van Limbergen,Gossum Av,Vatn Mh,Zhang H,Zhang W +191 more
TL;DR: While MS is most likely initially triggered by perturbation of peripheral immune responses the functional responses of microglia and other brain cells are also altered and may have a role in targeting an autoimmune process to the central nervous system.