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Darryl Falzarano
Researcher at Vaccine and Infectious Disease Organization
Publications - 81
Citations - 7271
Darryl Falzarano is an academic researcher from Vaccine and Infectious Disease Organization. The author has contributed to research in topics: Ebola virus & Medicine. The author has an hindex of 31, co-authored 66 publications receiving 5758 citations. Previous affiliations of Darryl Falzarano include Western University College of Veterinary Medicine & National Institutes of Health.
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Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
Journal ArticleDOI
Animal models for COVID-19.
César Muñoz-Fontela,William E. Dowling,Simon G. P. Funnell,Pierre Stéphane Gsell,A. Ximena Riveros-Balta,Randy A. Albrecht,Hanne Leth Andersen,Ralph S. Baric,Miles W. Carroll,Marco Cavaleri,Chuan Qin,Ian Crozier,Kai Dallmeier,Leon de Waal,Emmie de Wit,Leen Delang,Erik D. Dohm,W. Paul Duprex,Darryl Falzarano,Courtney L. Finch,Matthew B. Frieman,Barney S. Graham,Lisa E. Gralinski,Kate Guilfoyle,Bart L. Haagmans,Geraldine A. Hamilton,Amy L. Hartman,Sander Herfst,Suzanne J.F. Kaptein,William B. Klimstra,Ivana Knezevic,Philip R. Krause,Jens H. Kuhn,Roger Le Grand,Mark G. Lewis,Wen-Chun Liu,Pauline Maisonnasse,Anita K. McElroy,Vincent J. Munster,Nadia Oreshkova,Angela L. Rasmussen,Joana Rocha-Pereira,Barry Rockx,Estefanía Rodríguez,Thomas F. Rogers,Francisco J. Salguero,Michael Schotsaert,Koert J. Stittelaar,Hendrik Jan Thibaut,Chien Te K. Tseng,Júlia Vergara-Alert,Martin Beer,Trevor Brasel,Jasper Fuk-Woo Chan,Adolfo García-Sastre,Johan Neyts,Stanley Perlman,Douglas S. Reed,Juergen A. Richt,Chad J. Roy,Joaquim Segalés,Seshadri S. Vasan,Seshadri S. Vasan,Ana Maria Henao-Restrepo,Dan H. Barouch +64 more
TL;DR: The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.
Journal ArticleDOI
Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques
Darryl Falzarano,Emmie de Wit,Angela L. Rasmussen,Friederike Feldmann,Atsushi Okumura,Dana P. Scott,Doug Brining,Trenton Bushmaker,Cynthia Martellaro,Laura Baseler,Arndt Benecke,Arndt Benecke,Michael G. Katze,Vincent J. Munster,Heinz Feldmann,Heinz Feldmann +15 more
TL;DR: Treatment of MERS-CoV infected rhesus macaques with IFN-α2b and ribavirin reduces virus replication, moderates the host response and improves clinical outcome.
Journal ArticleDOI
Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques
Emmie de Wit,Angela L. Rasmussen,Darryl Falzarano,Trenton Bushmaker,Friederike Feldmann,Douglas Brining,Elizabeth R. Fischer,Cynthia Martellaro,Atsushi Okumura,Jean Chang,Dana P. Scott,Arndt Benecke,Arndt Benecke,Michael G. Katze,Heinz Feldmann,Vincent J. Munster +15 more
TL;DR: The MERS-CoV rhesus macaque model will be instrumental in developing and testing vaccine and treatment options for an emerging viral pathogen with pandemic potential and may explain the severity of the disease observed in humans and the limited human-to-human transmission.
Journal ArticleDOI
Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin.
Darryl Falzarano,Emmie de Wit,Cynthia Martellaro,Julie Callison,Vincent J. Munster,Heinz Feldmann +5 more
TL;DR: A combination of interferon-α2b and ribavirin, which are already commonly used in the clinic, may be useful for patient management in the event of future nCoV infections.