David Staunton

TL;DR: The structure of murine leukemia inhibitory factor has been determined by X-ray crystallography at 2.0 A resolution and sequence alignments for the functionally related molecules oncostatin M and ciliary neurotrophic factor, when mapped to the LIF structure, indicate regions of conserved surface character.

TL;DR: The structure of the cytokine‐binding homology region of the cell surface receptor gp130 has been determined by X‐ray crystallography at 2.0 Å resolution and suggests a limited flexibility in relative domain orientation of some 3°.

TL;DR: It is shown that the GPCR proteolytic site (GPS) motif, the molecular hallmark feature of the entire aGPCR class, is essential for LAT-1 signaling serving in two different activity modes of the receptor.

TL;DR: A multi-laboratory study to establish the precision and accuracy of basic data dimensions in AUC and validate previously proposed calibration techniques highlights the necessity and effectiveness of independent calibration of basic AUC data dimensions for reliable quantitative studies.

TL;DR: This work presents the solution structures of the second type III domain of human FN (2FNIII), and that of an interaction complex between the first two type III domains (1−2FN III), and speculate on the importance of this interaction for FN function.