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Deborah J. Cook
Researcher at McMaster University
Publications - 942
Citations - 165225
Deborah J. Cook is an academic researcher from McMaster University. The author has contributed to research in topics: Intensive care & Randomized controlled trial. The author has an hindex of 173, co-authored 907 publications receiving 148928 citations. Previous affiliations of Deborah J. Cook include McMaster University Medical Centre & Queen's University.
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Journal ArticleDOI
Heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic review and meta-analysis of randomized trials.
Waleed Alhazzani,Wendy Lim,Roman Jaeschke,Mohammad Hassan Murad,John F. Cade,Deborah J. Cook +5 more
TL;DR: Trial evidence to date suggests that any type of heparin thromboprophylaxis decreases deep vein thromboembolism and pulmonary embolism in medical-surgical critically ill patients, and low-molecular-weight Heparin compared with bid unfractionatedheparin decreases pulmonary emblism and symptomatic pulmonary embolia.
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The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis.
Ryan Zarychanski,Ahmed M Abou-Setta,Salmaan Kanji,Alexis F. Turgeon,Anand Kumar,Donald S. Houston,Emily Rimmer,Brett L. Houston,Lauralyn McIntyre,Alison Fox-Robichaud,Paul C. Hébert,Deborah J. Cook,Dean Fergusson +12 more
TL;DR: Heparin in patients with sepsis, septic shock, and disseminated intravascular coagulation associated with infection may be associated with decreased mortality; however, the overall impact remains uncertain.
Journal ArticleDOI
The Age of Blood Evaluation (ABLE) Randomized Controlled Trial: Study Design
Jacques Lacroix,Paul C. Hébert,Dean Fergusson,Alan Tinmouth,Morris A. Blajchman,Jeannie Callum,Deborah J. Cook,John C. Marshall,Lauralyn McIntyre,Alexis F. Turgeon +9 more
TL;DR: The ABLE study will test the hypothesis that the transfusion of prestorage leukoreduced RBCs stored for 7 days or less as compared with standard-issue RBCS stored, on average, 15 to 20 days will lead to lower 90-day all-cause mortality and reduced morbidity in critically ill adults.
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Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis.
TL;DR: An evidence-based approach is outlined to the assessment of preclinical animal studies evaluating novel therapeutic interventions in sepsis and the steps that are necessary to assess the internal validity of an individual study are discussed.
Journal ArticleDOI
Impact of a clinical pharmacist in a multidisciplinary intensive care unit
Mitra Montazeri,Deborah J. Cook +1 more
TL;DR: Dedicated ICU pharmacists are crucial healthcare team members in a multidisciplinary ICU that provide continuity in individualized pharmacotherapeutic care, and serve an important educational function in addition to substantially reducing drug costs.