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Deborah J. Cook
Researcher at McMaster University
Publications - 942
Citations - 165225
Deborah J. Cook is an academic researcher from McMaster University. The author has contributed to research in topics: Intensive care & Randomized controlled trial. The author has an hindex of 173, co-authored 907 publications receiving 148928 citations. Previous affiliations of Deborah J. Cook include McMaster University Medical Centre & Queen's University.
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Journal ArticleDOI
How to use an article on therapy or prevention: pneumonia prevention using subglottic secretion drainage.
Deborah J. Cook,Paul C. Hébert,Daren K. Heyland,Gordon H. Guyatt,Christian Brun-Buisson,John C. Marshall,James A. Russell,Jean Louis Vincent,Charles L. Sprung,Frank Rutledge +9 more
TL;DR: This approach may aid in the interpretation of an article on therapy or prevention; in it, a strategy designed to prevent ventilator associated pneumonia in critically ill patients is discussed.
Journal ArticleDOI
Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients.
Michelle E. Kho,Alexander J. Molloy,Julie C. Reid,Margaret S. Herridge,Tim Karachi,Bram Rochwerg,Alison Fox-Robichaud,Andrew J.E. Seely,Sunita Mathur,Vincent Lo,Karen E. A. Burns,Ian M Ball,Joseph R. Pellizzari,Jean-Eric Tarride,Jill C. Rudkowski,Karen Koo,Diane Heels-Ansdell,Deborah J. Cook +17 more
TL;DR: The pilot RCT suggests that a future multicentre RCT of early in-bed cycling for MV patients in the ICU is feasible and ascertainment rates for the primary outcome for the main trial (Physical Function ICU Test-scored at hospital discharge) are reported.
Journal ArticleDOI
Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2).
Matthias Briel,Matthias Briel,Melanie A. Lane,Victor M. Montori,Dirk Bassler,Paul Glasziou,Germán Málaga,Elie A. Akl,Ignacio Ferreira-González,Pablo Alonso-Coello,Gerard Urrútia,Regina Kunz,Carolina Ruiz Culebro,Suzana A. Silva,David N. Flynn,Mohamed B. Elamin,Brigitte Strahm,M. Hassan Murad,Benjamin Djulbegovic,Neill K. J. Adhikari,Edward J Mills,Femida Gwadry-Sridhar,Haresh Kirpalani,Haresh Kirpalani,Heloisa P. Soares,Nisrin O. Abu Elnour,John J. You,Paul J. Karanicolas,Heiner C. Bucher,Julianna F. Lampropulos,Alain J Nordmann,Karen E. A. Burns,Sohail M. Mulla,Heike Raatz,Amit Sood,Jagdeep Kaur,Clare Bankhead,Rebecca J. Mullan,Kara Nerenberg,Per Olav Vandvik,Fernando Coto-Yglesias,Holger J. Schünemann,Fábio Antônio Abrantes Tuche,Pedro Paulo M. Chrispim,Deborah J. Cook,Kristina Lutz,Christine Ribic,Noah Vale,Patricia J. Erwin,Rafael Perera,Qi Zhou,Diane Heels-Ansdell,Tim Ramsay,Stephen D. Walter,Gordon H. Guyatt +54 more
TL;DR: A better understanding of the extent to which tRCTs exaggerate treatment effects and of the factors associated with the magnitude of this bias can optimize trial design and data monitoring charters, and may aid in the interpretation of the results from trials stopped early for benefit.
Journal ArticleDOI
Attitudes of Swedish physicians and nurses towards the use of life-sustaining treatment.
TL;DR: Withdrawal or withholding of life‐sustaining treatment have become accepted clinical practice within the intensive care unit (ICU) and one important factor influencing these decisions is the attitudes of physicians and nurses.
Journal ArticleDOI
Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis.
Tasnim Sinuff,Deborah J. Cook,Deborah J. Cook,John C. Peterson,John C. Peterson,H. D. Fuller,H. D. Fuller +6 more
TL;DR: Development and implementation of a prophylactic ketoconazole practice guideline for ICU patients at high risk of ARDS was associated with a higher prescription of ketoconzole and a lower rate of AR DS in the study hospital than in the control hospital.