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Deborah J. Cook
Researcher at McMaster University
Publications - 942
Citations - 165225
Deborah J. Cook is an academic researcher from McMaster University. The author has contributed to research in topics: Intensive care & Randomized controlled trial. The author has an hindex of 173, co-authored 907 publications receiving 148928 citations. Previous affiliations of Deborah J. Cook include McMaster University Medical Centre & Queen's University.
Papers
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Journal ArticleDOI
Higher vs Lower Positive End-Expiratory Pressure in Patients With Acute Lung Injury and Acute Respiratory Distress Syndrome: Systematic Review and Meta-analysis
Matthias Briel,Maureen O. Meade,Alain Mercat,Roy G. Brower,Daniel Talmor,Stephen D. Walter,Arthur S. Slutsky,Eleanor Pullenayegum,Qi Zhou,Deborah J. Cook,Laurent Brochard,Jean-Christophe Richard,Francois Lamontagne,Francois Lamontagne,Neera Bhatnagar,Thomas E. Stewart,Gordon H. Guyatt +16 more
TL;DR: Evaluating the association of higher vs lower PEEP with patient-important outcomes in adults with acute lung injury or ARDS who are receiving ventilation with low tidal volumes found that higher levels were associated with improved survival among the subgroup of patients with ARDS, but lower levels were not associated withImproved hospital survival.
Journal ArticleDOI
Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome A Randomized Controlled Trial
Maureen O. Meade,Deborah J. Cook,Gordon H. Guyatt,Arthur S. Slutsky,Yaseen M. Arabi,D. James Cooper,Andrew Davies,Qi Zhou,Lehana Thabane,Peggy Austin,Stephen E. Lapinsky,A.T. Baxter,James A. Russell,Yoanna Skrobik,Juan J. Ronco,Thomas E. Stewart +15 more
TL;DR: For patients with acute lung injury and acute respiratory distress syndrome, a multifaceted protocolized ventilation strategy designed to recruit and open the lung resulted in no significant difference in all-cause hospital mortality or barotrauma compared with an established low-tidal-volume protocolized breathing strategy.
Book
Users' guides to the medical literature : a manual for evidence-based clinical practice
TL;DR: The third edition of this landmark resource is now completely revised and refreshed throughout, with expanded coverage of both basic and advanced issues in using evidence-based medicine in clinical practice.
Journal ArticleDOI
Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement
TL;DR: The Quality of Reporting of Meta‐analyses (QUOROM) conference was convened to address standards for improving the quality of reporting of meta-analyses of clinical randomised controlled trials (RCTs).
Journal ArticleDOI
Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data
Donald E. G. Griesdale,Russell J. de Souza,Rob M. van Dam,Daren K. Heyland,Deborah J. Cook,Atul Malhotra,Rupinder Dhaliwal,William R. Henderson,Dean R. Chittock,Simon Finfer,Daniel Talmor +10 more
TL;DR: Intensive insulin therapy significantly increased the risk of hypoglycemia and conferred no overall mortality benefit among critically ill patients, but this therapy may be beneficial to patients admitted to a surgical ICU.