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Deborah J. Cook
Researcher at McMaster University
Publications - 942
Citations - 165225
Deborah J. Cook is an academic researcher from McMaster University. The author has contributed to research in topics: Intensive care & Randomized controlled trial. The author has an hindex of 173, co-authored 907 publications receiving 148928 citations. Previous affiliations of Deborah J. Cook include McMaster University Medical Centre & Queen's University.
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Journal ArticleDOI
Systematic review of reviews including animal studies addressing therapeutic interventions for sepsis.
Francois Lamontagne,Matthias Briel,Mark Duffett,Alison Fox-Robichaud,Deborah J. Cook,Gordon H. Guyatt,Olivier Lesur,Maureen O. Meade +7 more
TL;DR: This work assesses literature reviews of therapeutic interventions for sepsis that include animal experiments for explicit appraisals of the risk of bias and clinical relevance and proposes a framework to enhance these features in future reviews of preclinical research.
Journal ArticleDOI
7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.
Nick Daneman,Asgar H. Rishu,Ruxandra Pinto,Pierre Aslanian,Sean M. Bagshaw,Alex Carignan,Emmanuel Charbonney,Bryan Coburn,Deborah J. Cook,Michael E. Detsky,Peter Dodek,Richard I. Hall,Anand Kumar,Francois Lamontagne,François Lauzier,John C. Marshall,Claudio Martin,Lauralyn McIntyre,John Muscedere,Steven Reynolds,Wendy I Sligl,Henry T. Stelfox,M. E Wilcox,Robert A. Fowler +23 more
TL;DR: It is feasible to conduct a RCT to determine whether 7 versus 14 days of antibiotic treatment is associated with comparable 90-day survival, and recruitment rate and adherence to treatment duration protocol were feasible.
Journal ArticleDOI
The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia
Daren K. Heyland,Deborah J. Cook,Deborah J. Cook,John Marshall,John Marshall,Mark Heule,Mark Heule,Ben Guslits,Ben Guslits,Jeff Lang,Jeff Lang,Roman Jaeschke,Roman Jaeschke +12 more
TL;DR: Invasive diagnostic testing may increase physician confidence in the diagnosis and management of VAP and allows for greater ability to limit or discontinue antibiotic treatment.
Journal ArticleDOI
Risk factors for mortality in patients admitted to intensive care units with pneumonia
Guowei Li,Guowei Li,Deborah J. Cook,Lehana Thabane,Lehana Thabane,Jan O. Friedrich,Tim M. Crozier,John Muscedere,John Granton,John Granton,Sangeeta Mehta,Steven Reynolds,Renato D. Lopes,Lauzier Francois,Andreas Freitag,Mitchell Levine,Mitchell Levine +16 more
TL;DR: It was found that male sex, higher APACHE II score on admission, chronic heart failure, and dialysis were independently associated with risk of hospital mortality in patients admitted to ICU with pneumonia.
Journal ArticleDOI
DNR directives are established early in mechanically ventilated intensive care unit patients.
Tasnim Sinuff,Deborah J. Cook,Graeme Rocker,Lauren Griffith,Stephen D. Walter,M. McD. Fisher,Peter Dodek,Peter Sjokvist,Ellen McDonald,John C. Marshall,Peter A. Kraus,Mitchell M. Levy,Neil M. Lazar,Gordon H. Guyatt +13 more
TL;DR: One third of mechanically ventilated patients had DNR directives established early during their ICU stay after the first 24 hr of admission, and the strongest predictors were physician prediction of low probability of survival, physician perception of patient preference to limit life support, organ dysfunction, medical diagnosis and age.