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Eric B. Larson
Researcher at Kaiser Permanente
Publications - 25
Citations - 6263
Eric B. Larson is an academic researcher from Kaiser Permanente. The author has contributed to research in topics: Dementia & Population. The author has an hindex of 16, co-authored 25 publications receiving 5492 citations. Previous affiliations of Eric B. Larson include University of Washington & Group Health Cooperative.
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Journal ArticleDOI
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Adam C. Naj,Gyungah Jun,Gary W. Beecham,Li-San Wang,Badri N. Vardarajan,Jacqueline L. Buros,Paul Gallins,Joseph D. Buxbaum,Gail P. Jarvik,Paul K. Crane,Eric B. Larson,Thomas D. Bird,Bradley F. Boeve,Neill R. Graff-Radford,Philip L. De Jager,Philip L. De Jager,Denis A. Evans,Julie A. Schneider,Minerva M. Carrasquillo,Nilufer Ertekin-Taner,Steven G. Younkin,Carlos Cruchaga,John S. K. Kauwe,Petra Nowotny,Patricia L. Kramer,John Hardy,Matthew J. Huentelman,Amanda J. Myers,M. Michael Barmada,F. Yesim Demirci,Clinton T. Baldwin,Robert C. Green,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Steven E. Arnold,Robert W Barber,Thomas H. Beach,Eileen H. Bigio,James D. Bowen,Adam L. Boxer,James R. Burke,Nigel J. Cairns,Christopher S. Carlson,Regina M. Carney,Steven L. Carroll,Helena C. Chui,David G. Clark,Jason J. Corneveaux,Carl W. Cotman,Jeffrey L. Cummings,Charles DeCarli,Steven T. DeKosky,Ramon Diaz-Arrastia,Malcolm B. Dick,Dennis W. Dickson,William G. Ellis,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Sid Gilman,Bruno Giordani,Jonathan D. Glass,John H. Growdon,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee-Way Jin,Nancy Johnson,Jason Karlawish,Anna Karydas,Jeffrey Kaye,Ronald C. Kim,Edward H. Koo,Neil W. Kowall,James J. Lah,Allan I. Levey,Andrew P. Lieberman,Oscar L. Lopez,Wendy J. Mack,Daniel C. Marson,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,W Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Joseph E. Parisi,Daniel P. Perl,Elaine R. Peskind,Ronald C. Petersen,Wayne W. Poon,Joseph F. Quinn,Ruchita Rajbhandary,Murray A. Raskind,Barry Reisberg,John M. Ringman,Erik D. Roberson,Roger N. Rosenberg,Mary Sano,Lon S. Schneider,William P. Seeley,Michael L. Shelanski,Michael A. Slifer,Charles D. Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,John Q. Trojanowski,Juan C. Troncoso,Vivianna M. Van Deerlin,Harry V. Vinters,Jean Paul Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Randall L. Woltjer,Laura B. Cantwell,Beth A. Dombroski,Duane Beekly,Kathryn L. Lunetta,Eden R. Martin,M. Ilyas Kamboh,Andrew J. Saykin,Eric M. Reiman,David A. Bennett,John C. Morris,Thomas J. Montine,Alison Goate,Deborah Blacker,Debby W. Tsuang,Hakon Hakonarson,Walter A. Kukull,Tatiana Foroud,Jonathan L. Haines,Richard Mayeux,Margaret A. Pericak-Vance,Lindsay A. Farrer,Gerard D. Schellenberg +156 more
TL;DR: The Alzheimer Disease Genetics Consortium performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1), two replication stages (stages 2 and 3), and both joint analysis and meta-analysis approaches were used.
Journal ArticleDOI
Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older
Eric B. Larson,Li Wang,James D. Bowen,Wayne C. McCormick,Linda Teri,Paul K. Crane,Walter A. Kukull +6 more
TL;DR: This study found that regular exercise is associated with a reduced risk for incidence of dementia in a cohort followed biennially over 6 years and examined whether the association of physical exercise with incident dementia is modulated by other potential risk factors.
Journal ArticleDOI
A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012
Kenneth M. Langa,Eric B. Larson,Eileen M. Crimmins,Jessica D. Faul,Deborah A. Levine,Mohammed U. Kabeto,David R. Weir +6 more
TL;DR: The prevalence of dementia in the United States declined significantly between 2000 and 2012, and an increase in educational attainment was associated with some of the decline in dementia prevalence, but the full set of social, behavioral, and medical factors contributing to the decline is still uncertain.
Rare and low-frequency coding variants alter human adult height
Eirini Marouli,Mariaelisa Graff,Carolina Medina-Gomez,Ken Sin Lo,Andrew R. Wood,Troels R. Kjaer,Rebecca S. Fine,Yingchang Lu,Claudia Schurmann,Heather M. Highland,Sina Rüeger,Gudmar Thorleifsson,Anne E. Justice,David Lamparter,Kathleen Stirrups,Valérie Turcot,Kristin L. Young,Thomas W. Winkler,Tõnu Esko,Tugce Karaderi,Adam E. Locke,Nicholas G. D. Masca,Maggie C.Y. Ng,Poorva Mudgal,Manuel A. Rivas,Sailaja Vedantam,Anubha Mahajan,Xiuqing Guo,Gonçalo R. Abecasis,Katja K.H. Aben,Linda S. Adair,Dewan S. Alam,Eva Albrecht,Kristine H. Allin,Matthew A. Allison,Philippe Amouyel,Emil V. R. Appel,Dominique Arveiler,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Bernhard Banas,Lia E. Bang,Marianne Benn,Sven Bergmann,Lawrence F. Bielak,Matthias Blueher,Heiner Boeing,Eric Boerwinkle,Carsten A. Boeger,Lori L. Bonnycastle,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Murray H. Brilliant,Linda Broer,Amber A. Burt,Adam S. Butterworth,David J. Carey,Mark J. Caulfield,John C. Chambers,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,Gabriel Cuellar-Partida,John Danesh,Gail Davies,Paul I.W. de Bakker,Gert J. de Borst,Simon de Denus,Mark C.H. De Groot,Renée de Mutsert,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Anneke I. den Hollander,Joe Dennis,Emanuele Di Angelantonio,Fotios Drenos,Mengmeng Du,Alison M. Dunning,Douglas F. Easton,Tapani Ebeling,Todd L. Edwards,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,Jessica D. Faul,Mary F. Feitosa,Shuang Feng,Ele Ferrannini,Marco M Ferrario,Jean Ferrières,Jose C. Florez,Ian Ford,Myriam Fornage,Paul W. Franks,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Ayush Giri,Giorgia Girotto,Scott D. Gordon,Penny Gordon-Larsen,Mathias Gorski,Niels Grarup,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Caroline Hayward,Liang He,Iris M. Heid,Kauko Heikkilä,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Lynne J. Hocking,Mette Hollensted,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Carel B. Hoyng,Paul L. Huang,Kristian Hveem,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Min A. Jhun,Yucheng Jia,Xuejuan Jiang,Stefan Johansson,Marit E. Jørgensen,Torben Jørgensen,Pekka Jousilahti,J. Wouter Jukema,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Frank Kee,Renske Keeman,Lambertus A. Kiemeney,Hidetoshi Kitajima,Kirsten B. Kluivers,Thomas D. Kocher,Pirjo Komulainen,Jukka Kontto,Jaspal S. Kooner,Charles Kooperberg,Peter Kovacs,Jennifer Kriebel,Helena Kuivaniemi,Sébastien Küry,Johanna Kuusisto,Martina La Bianca,Markku Laakso,Timo A. Lakka,Ethan M. Lange,Leslie A. Lange,Carl D. Langefeld,Claudia Langenberg,Eric B. Larson,I-Te Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Y Liu,Yongmei Liu,Artitaya Lophatananon,Jian'an Luan,Steven A. Lubitz,Leo-Pekka Lyytikäinen,David A. Mackey,Pamela A. F. Madden,Alisa K. Manning,Satu Männistö,Gaëlle Marenne,Jonathan Marten,Nicholas G. Martin,Angela L. Mazul,Karina Meidtner,Andres Metspalu,Paul Mitchell,Karen L. Mohlke,Dennis O. Mook-Kanamori,Anna Morgan,Andrew D. Morris,Andrew P. Morris,Martina Mueller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Matthias Nauck,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Ioanna Ntalla,Jeffrey R. O'Connel,Heikki Oksa,Loes M. Olde Loohuis,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,James A. Perry,John R. B. Perry,Thomas N. Person,Ailith Pirie,Ozren Polasek,Danielle Posthuma,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Alexander P. Reiner,Frida Renström,Paul M. Ridker,John D. Rioux,Neil Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Kevin Sandow,Yadav Sapkota,Naveed Sattar,Marjanka K. Schmidt,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Albert V. Smith,Jennifer A. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael Stumvoll,Praveen Surendran,Leen M 't Hart,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Toenjes,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Sheila Ulivi,Sander W. van der Laan,Andries R. van der Leij,Cornelia M. van Duijn,Natasja M. van Schoor,Jessica van Setten,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Diego Vozzi,Mark Walker,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Nicholas J. Wareham,Helen R. Warren,Jennifer Wessel,Sara M. Willems,James G. Wilson,Daniel R. Witte,Michael O. Woods,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,He Zheng,Wei Zhou,Jerome I. Rotter,Michael Boehnke,Sekar Kathiresan,Mark I. McCarthy,Cristen J. Willer,Kari Stefansson,Ingrid B. Borecki,Dajiang J. Liu,Kari E. North,Nancy L. Heard-Costa,Tune H. Pers,Cecilia M. Lindgren,Claus Oxvig,Zoltán Kutalik,Fernando Rivadeneira,Ruth J. F. Loos,Timothy M. Frayling,Joel N. Hirschhorn,Panos Deloukas,Guillaume Lettre +370 more
TL;DR: The results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
Journal ArticleDOI
Trends in the prevalence and mortality of cognitive impairment in the United States: Is there evidence of a compression of cognitive morbidity?
Kenneth M. Langa,Kenneth M. Langa,Eric B. Larson,Jason Karlawish,David M. Cutler,Mohammed U. Kabeto,Scott Y. H. Kim,Allison B. Rosen,Allison B. Rosen +8 more
TL;DR: The prevalence and 2‐year mortality of cognitive impairment consistent with dementia in the United States in 1993 to 1995 and 2002 to 2004 were compared to assess the impact of multiple trends.