Rolf D. Horstmann

TL;DR: The antiphagocytic activity of streptococcal M protein may be due to complement inhibition mediated by the binding of factor H, which appears to be a previously unrecognized route by which a pathogen is able to evade alternative pathway activation.

TL;DR: The combination of drug resistance and compensatory mutations displayed by the major clades confers clinical resistance without compromising fitness and transmissibility, showing that, in addition to weaknesses in the tuberculosis control program, biological factors drive the persistence and spread of MDR and XDR tuberculosis in Russia and beyond.

TL;DR: These findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.

TL;DR: This study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

TL;DR: Two previously unknown loci associated with severe falciparum malaria in patients and controls from Ghana, West Africa are identified and underline the potential of the GWA approach to provide candidates for the development of control measures against infectious diseases in humans.