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Anna E. Jeffreys
Researcher at University of Oxford
Publications - 35
Citations - 2545
Anna E. Jeffreys is an academic researcher from University of Oxford. The author has contributed to research in topics: Malaria & Population. The author has an hindex of 16, co-authored 34 publications receiving 2021 citations. Previous affiliations of Anna E. Jeffreys include Wellcome Trust Centre for Human Genetics & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
Magnus Manske,Magnus Manske,Olivo Miotto,Olivo Miotto,Susana Campino,Susana Campino,Sarah Auburn,Sarah Auburn,Sarah Auburn,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Gareth Maslen,Gareth Maslen,John O'Brien,John O'Brien,Abdoulaye A. Djimde,Ogobara K. Doumbo,Issaka Zongo,Jean-Bosco Ouédraogo,Pascal Michon,Ivo Mueller,Peter Siba,Alexis Nzila,Steffen Borrmann,Steven M. Kiara,Kevin Marsh,Hongying Jiang,Xin-zhuan Su,Chanaki Amaratunga,Rick M. Fairhurst,Duong Socheat,François Nosten,François Nosten,Mallika Imwong,Nicholas J. White,Nicholas J. White,Mandy Sanders,Elisa Anastasi,Dan Alcock,Eleanor Drury,Samuel O. Oyola,Michael A. Quail,Daniel J. Turner,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Dushyanth Jyothi,Dushyanth Jyothi,Lucas Amenga-Etego,Lucas Amenga-Etego,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Colin J. Sutherland,Cally Roper,Valentina D. Mangano,David Modiano,John C. Tan,Michael T. Ferdig,Alfred Amambua-Ngwa,David J. Conway,Shannon Takala-Harrison,Christopher V. Plowe,Julian C. Rayner,Kirk A. Rockett,Kirk A. Rockett,Kirk A. Rockett,Taane G. Clark,Taane G. Clark,Taane G. Clark,Chris I. Newbold,Chris I. Newbold,Matthew Berriman,Bronwyn MacInnis,Bronwyn MacInnis,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +78 more
TL;DR: Methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture are described.
Journal ArticleDOI
Genome-wide and fine-resolution association analysis of malaria in West Africa
Muminatou Jallow,Yik Ying Teo,Yik Ying Teo,Kerrin S. Small,Kerrin S. Small,Kirk A. Rockett,Kirk A. Rockett,Panos Deloukas,Taane G. Clark,Taane G. Clark,Katja Kivinen,Kalifa Bojang,David J. Conway,Margaret Pinder,Giorgio Sirugo,Fatou Sisay-Joof,Stanley Usen,Sarah Auburn,Sarah Auburn,Suzannah Bumpstead,Susana Campino,Susana Campino,Alison J. Coffey,Andrew Dunham,Andrew E. Fry,Angela Green,Rhian Gwilliam,Sarah E. Hunt,Michael Inouye,Anna E. Jeffreys,Alieu Mendy,Aarno Palotie,Simon C. Potter,Jiannis Ragoussis,Jane Rogers,Kate Rowlands,Elilan Somaskantharajah,Pamela Whittaker,Claire Widden,Peter Donnelly,Bryan Howie,Jonathan Marchini,Andrew P. Morris,Miguel A. Sanjoaquin,Miguel A. Sanjoaquin,Eric A. Achidi,Tsiri Agbenyega,Angela Allen,Angela Allen,Olukemi K. Amodu,Patrick H. Corran,Abdoulaye A. Djimde,Amagana Dolo,Ogobara K. Doumbo,Chris Drakeley,Sarah J. Dunstan,Jennifer Evans,Jennifer Evans,Jeremy Farrar,Deepika Fernando,Tran Tinh Hien,Rolf D. Horstmann,Muntaser E. Ibrahim,Nadira D. Karunaweera,Gilbert Kokwaro,Kwadwo A. Koram,Martha M. Lemnge,Julie Makani,Kevin Marsh,Pascal Michon,David Modiano,Malcolm E. Molyneux,Ivo Mueller,Michael Parker,Norbert Peshu,Christopher V. Plowe,Odile Puijalon,John C. Reeder,Hugh Reyburn,Eleanor M. Riley,Anavaj Sakuntabhai,Pratap Singhasivanon,Sodiomon B. Sirima,Adama Tall,Terrie E. Taylor,Mahamadou A. Thera,Marita Troye-Blomberg,Thomas N. Williams,Michael T. Wilson,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +90 more
TL;DR: These findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.
Journal ArticleDOI
Genetic diversity of the African malaria vector Anopheles gambiae.
Alistair Miles,Alistair Miles,Nicholas J. Harding,Giordano Bottà,Giordano Bottà,Chris S Clarkson,Chris S Clarkson,Tiago Antao,Tiago Antao,Tiago Antao,Krzysztof Kozak,Daniel R. Schrider,Andrew D. Kern,Seth Redmond,Igor V. Sharakhov,Igor V. Sharakhov,Richard D. Pearson,Richard D. Pearson,Christina M. Bergey,Michael C. Fontaine,Martin J. Donnelly,Martin J. Donnelly,Mara K. N. Lawniczak,Diego Ayala,Nora J. Besansky,Austin Burt,Beniamino Caputo,Alessandra della Torre,H. Charles J. Godfray,Matthew W. Hahn,Janet Midega,Daniel E. Neafsey,Samantha M. O’Loughlin,João Pinto,Michelle M. Riehle,Kenneth D. Vernick,David Weetman,Craig S. Wilding,Craig S. Wilding,Bradley J. White,Arlete D. Troco,Abdoulaye Diabaté,Carlo Costantini,Kyanne R. Rohatgi,Nohal Elissa,Boubacar Coulibaly,Joao Dinis,Charles M. Mbogo,Philip Bejon,Henry D. Mawejje,Jim Stalker,Kirk A. Rockett,Eleanor Drury,Daniel Mead,Anna E. Jeffreys,Christina Hubbart,Kate Rowlands,Alison T. Isaacs,Dushyanth Jyothi,Cinzia Malangone,Paul Vauterin,Ben Jeffery,Ian J. Wright,Lee Hart,Krzysztof Kluczynski,Victoria Cornelius,Bronwyn MacInnis,Christa Henrichs,Rachel Giacomantonio,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +70 more
TL;DR: These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size.
Journal ArticleDOI
Reappraisal of known malaria resistance loci in a large multicenter study.
Kirk A. Rockett,Geraldine M. Clarke,Kathryn Fitzpatrick,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Rachel Craik,M Jallow,David J. Conway,Kalifa Bojang,Margaret Pinder,Stanley Usen,Fatoumatta Sisay-Joof,Giorgio Sirugo,Ousmane Touré,Mahamadou A. Thera,Salimata Konate,Sibiry Sissoko,Amadou Niangaly,Belco Poudiougou,Valentina D. Mangano,Edith C. Bougouma,Sodiomon B. Sirima,David Modiano,L. Amenga-Etego,Anita Ghansah,Kwadwo A. Koram,Michael D. Wilson,Anthony Enimil,Jennifer R Evans,Olukemi K. Amodu,Subulade A. Olaniyan,Tobias O. Apinjoh,Regina N. Mugri,Andre Ndi,Carolyne M. Ndila,Sophie Uyoga,Alexander Macharia,Norbert Peshu,Thomas N. Williams,Alphaxard Manjurano,Eleanor M. Riley,Chris Drakeley,Hugh Reyburn,Vysaul Nyirongo,David Kachala,Malcolm E. Molyneux,Sarah J. Dunstan,Nguyen Hoan Phu,Nguyen Ngoc Quyen,Cao Quang Thai,Tran Tinh Hien,Laurens Manning,Moses Laman,Peter Siba,Harin Karunajeewa,Steve Allen,Angela Allen,Timothy M. E. Davis,Pascal Michon,Ivo Mueller,Angie Green,Síle F. Molloy,Kimberly J. Johnson,Angeliki Kerasidou,Victoria Cornelius,Lee Hart,Aaron Vanderwal,Miguel A. Sanjoaquin,Gavin Band,Si Quang Le,Matti Pirinen,Nuno Sepúlveda,Chris C. A. Spencer,Taane G. Clark,Tsiri Agbenyega,Eric A. Achidi,Ogobara K. Doumbo,Jeremy Farrar,Kevin Marsh,Terrie E. Taylor,Dominic P. Kwiatkowski +81 more
TL;DR: The finding that G6PD deficiency has opposing effects on different fatal complications of P. falciparum infection indicates that the evolutionary origins of this common human genetic disorder are more complex than previously supposed.
Journal ArticleDOI
Admixture into and within sub-Saharan Africa
Busby Gbj.,Quang Si Le,Muminatou Jallow,Edith Bougama,Valentina D. Mangano,Lucas Amenga-Etego,Anthony Enimil,Tobias O. Apinjoh,Carolyne M. Ndila,Alphaxard Manjurano,Alphaxard Manjurano,Vysaul Nyirongo,Ogobara K. Doumbo,Kirk A. Rockett,Kirk A. Rockett,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Spencer Cca.,Aaron Vanderwal,Aaron Vanderwal,Abier Elzein,Abier Elzein,A Nyika,A Nyika,Alieu Mendy,Alieu Mendy,Alistair Miles,Alistair Miles,A Diss,A Diss,Angeliki Kerasidou,Angeliki Kerasidou,Angie Green,Angie Green,Anna E. Jeffreys,Anna E. Jeffreys,Bronwyn MacInnis,Bronwyn MacInnis,C Hughes,C Hughes,Catherine L. Moyes,Catherine L. Moyes,Christina Hubbart,Christina Hubbart,C Malangone,C Malangone,C Potter,C Potter,D Mead,D Mead,D Barnwell,D Barnwell,Dushyanth Jyothi,Dushyanth Jyothi,E Drury,E Drury,E Somaskantharajah,E Somaskantharajah,E Hilton,E Hilton,Ellen M. Leffler,Ellen M. Leffler,Gareth Maslen,Gareth Maslen,George B.J. Busby,George B.J. Busby,Geraldine M. Clarke,Geraldine M. Clarke,I Ragoussis,I Ragoussis,Jacob Almagro Garcia,Jacob Almagro Garcia,J Rogers,J Rogers,J deVries,J deVries,J Shelton,J Shelton,Jiannis Ragoussis,Jiannis Ragoussis,J Stalker,J Stalker,J Rodford,J Rodford,J O'Brien +84 more
TL;DR: It is shown that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions.