Gad Getz

TL;DR: The prevalence and clinical significance of Amplification of the long arm of chromosome 1 (Amp1q) in patients with MM, its pathogenesis and therapeutic vulnerabilities, and the opportunities and challenges for Amp1q-targeted therapy are reviewed.

TL;DR: A significant change in clonal dynamics in one half of treated patients suggests that relapsed disease following treatment is driven by expansion of subclones under the selective pressure of chemotherapy rather than by novel mutagenesis, which suggests that pre-treatment WES may allow for the delineation of current genetic abnormalities, may also predict genetic evolution in future relapse.

TL;DR: This study eclipses previous large-scale characterization of somatic sequence variation in lung adenocarcinoma by at least an order of magnitude and is able to recover signals of selection in both known and novel genes and pathways.

TL;DR: In this paper , the authors demonstrate how to infer progression from exome sequencing of primary tumors using a clock-like mutational signature, and they associated the timing of transitions to aneuploidy with increased intratumor genetic heterogeneity and shorter overall survival.

TL;DR: The data suggests that single biopsies of primary tumors and metastases may not be sufficient to identify potential therapeutic targets, and sheds light on the evolutionary mechanisms in brain metastases.