G
Gad Getz
Researcher at Broad Institute
Publications - 627
Citations - 309042
Gad Getz is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 189, co-authored 520 publications receiving 247560 citations. Previous affiliations of Gad Getz include University of Colorado Denver & University of California, San Diego.
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Journal ArticleDOI
Reconstructing a Genotype-Phenotype Map In Chronic Lymphocytic Leukemia
Dylan Kotliar,Dan-Avi Landau,Oren Litvin,Petar Stojanov,Carrie Sougnez,Gordon Saksena,M. Eng,Donna Neuberg,Gad Getz,Jennifer R. Brown,Dana Pe'er,Nir Hacohen,Catherine J. Wu +12 more
TL;DR: The inferred CLL networks generate testable hypotheses that explain how genotypes affect the cellular circuitry of CLL cells that are currently being tested through functional gain/loss of function experiments.
Posted ContentDOI
Genome-wide mutational signatures of immunological diversification in normal lymphocytes
Heather E. Machado,Emily G. Mitchell,Emily G. Mitchell,Nina F. Øbro,Nina F. Øbro,K Kübler,K Kübler,Michael Davies,Francesco Maura,Daniel Leongamornlert,Mathijs A. Sanders,Mathijs A. Sanders,Alex Cagan,Craig McDonald,Craig McDonald,Miriam Belmonte,Miriam Belmonte,Mairi Shepherd,Robert J. Osborne,Krishnaa T. Mahbubani,Inigo Martincorena,Elisa Laurenti,Andrew Green,Gad Getz,Paz Polak,Kourosh Saeb-Parsy,Daniel J. Hodson,David G. Kent,David G. Kent,Peter J. Campbell,Peter J. Campbell +30 more
TL;DR: The mutational landscape of normal lymphocytes chronicles the off-target effects of programmed genome engineering during immunological diversification and the consequences of differentiation, proliferation and residency in diverse microenvironments.
Proceedings ArticleDOI
Abstract 999: The genomic landscape of pediatric Ewing sarcoma
Brian D. Crompton,Chip Stewart,Amaro Taylor-Weiner,Gabriela Alexa,Kyle C. Kurek,Monica L. Calicchio,Adam Kiezun,Scott L. Carter,Sachet A. Shukla,Swapnil Mehta,Aaron R. Thorner,Carmen de Torres,Cinzia Lavarino,Mariona Suñol,Aaron McKenna,Andrey Sivachenko,Kristian Cibulskis,Michael S. Lawrence,Lauren Ambrogio,Daniel Auclair,Ivan Imaz Rosshandler,Angela Schwarz-Cruz y Celis,Miguel Rivera,Carlos Rodriguez-Galindo,Mark D. Fleming,Todd R. Golub,Gad Getz,Jaume Mora,Kimberly Stegmaier +28 more
TL;DR: Crompton et al. as mentioned in this paper performed whole-exome sequencing of 96 Ewing sarcoma tumors and 11 Ewing SARcoma cell lines, as well as whole-genome sequencing, transcriptome sequencing and copy-number analysis of a subset of these samples.
Journal ArticleDOI
Abnormal Free Light Chains in Individuals with African Ancestry Screened for Monoclonal Gammopathy: Definition of New Reference Range Accounting for Renal Function and Race
L. Bertamini,Jean-Baptiste Alberge,Habib El-Khoury,David J Lee,Ciara Murphy,Grace Fleming,M. Davis,Jacqueline Perry,Christian J. Cea-Curry,Audrey Pentz,Thulisile Hlubi,Natalie A. Smyth,Dhananjay Sakrikar,Mark C. Perkins,Stephen E. Harding,Derek Troske,Gad Getz,Timothy R. Rebbeck,Maureen Joffe,Catherine R. Marinac,Nelson Leung,Carl Wenlong Chen,I R Ghobrial +22 more
TL;DR: For example, this paper found that African Americans (AA) have significantly higher Kappa (κ) and Lambda (λ) sFLC levels than European Americans (EA) in a biobanked population, even after adjusting for kidney function.
Proceedings ArticleDOI
Abstract 3992: Modes of metastasis evolution in human and murine cancer revealed by whole exome sequencing
Scott L. Carter,Priscilla K. Brastianos,David G. McFadden,Thales Papagiannakopoulos,Amaro Taylor-Weiner,Kristian Cibulskis,Tyler Jacks,William C. Hahn,Gad Getz +8 more
TL;DR: Evidence for the sequential spread of metastases is uncovered, consistent with multiregion sequencing of primary and metastatic human pancreatic cancer, and Modes of metastasis evolution in human and murine cancer revealed by whole exome sequencing are revealed.