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Gad Getz

Researcher at Broad Institute

Publications -  627
Citations -  309042

Gad Getz is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 189, co-authored 520 publications receiving 247560 citations. Previous affiliations of Gad Getz include University of Colorado Denver & University of California, San Diego.

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Journal ArticleDOI

Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas

Dariush Etemadmoghadam, +24 more
- 15 Feb 2009 - 
TL;DR: Two distinct mechanisms of primary treatment failure in serous ovarian cancer are identified, involving CCNE1 amplification and enhanced extracellular matrix deposition, andCCNE1 copy number is validated as a dominant marker of patient outcome in ovarian cancer.
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Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation

Helga B. Salvesen, +22 more
- 24 Mar 2009 - 
TL;DR: An integrated analysis of genome-wide expression and copy-number data for primary endometrial carcinomas with extensive clinical and histopathological data distinguished 2 major clusters with strikingly different phenotypes, including significant differences in disease-free survival.
Posted ContentDOI

The evolutionary history of 2,658 cancers

Moritz Gerstung, +45 more
- 11 Jul 2017 - 
TL;DR: Whole-genome sequencing of 2,778 tumour samples from 2,658 donors is used to reconstruct the life history, evolution of mutational processes, and driver mutation sequences of 39 cancer types, suggesting a window of opportunity for early cancer detection.
Journal ArticleDOI

The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

Orit Rozenblatt-Rosen, +373 more
- 16 Apr 2020 - 
TL;DR: The Human Tumor Atlas Network (HTAN), part of the NCI Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types.
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Somatic mutation of CDKN1B in small intestine neuroendocrine tumors

Joshua M. Francis, +55 more
- 01 Dec 2013 - 
TL;DR: Recurrent somatic mutations and deletions in CDKN1B, the cyclin-dependent kinase inhibitor gene, which encodes p27 are identified, nominating p27 as a tumor suppressor and implicating cell cycle dysregulation in the etiology of SI-NETs.