Gad Getz

TL;DR: Genomic analysis of brain metastases provides an opportunity to identify potentially clinically informative alterations not detected in clinically sampled primary tumors, regional lymph nodes, or extracranial metastases, suggesting that sequencing of primary biopsies alone may miss a substantial number of opportunities for targeted therapy.

TL;DR: Nozzle is an R package that provides an Application Programming Interface to generate HTML reports with dynamic user interface elements to facilitate summarization and rapid browsing of complex results in data analysis pipelines where multiple analyses are performed frequently on big datasets.

TL;DR: An essential role is revealed for p190A and p190B to promote contact inhibition of cell proliferation (CIP), a function that relies on RhoGAP activity, and a novel mechanism consistent with a tumor-suppressor function for ARHGAP35 is revealed.

TL;DR: In this paper, a single-cell mtDNA assay for transposase-accessible chromatin with sequencing to profile 163,279 cells from 9 patients with chronic lymphocytic leukemia (CLL) collected across disease course and utilize mitochondrial DNA (mtDNA) mutations as natural genetic markers of cancer clones.

TL;DR: Integrated genetic, transcriptomic, and epigenetic analyses of CLL cells from 10 patients revealed that the clinical kinetics of post-HSCT relapse are shaped by distinct molecular dynamics, which elucidate the biological pathways that underlie GvL resistance and posttransplant relapse.