Gad Getz

TL;DR: In this paper, the effects of radiation exposure from the Chernobyl nuclear accident were investigated in children born to parents employed as cleanup workers or exposed to occupational and environmental ionizing radiation after the accident.

TL;DR: It is shown that many cancer hotspot mutations recurring at the same genomic site across multiple tumors are actually passenger events, recurring at inherently mutable genomic sites under no positive selection.

TL;DR: It is suggested that management of HGT1 bladder cancer may be improved via molecular characterization to predict outcome via high mutational burden, ERCC2 mutations, and high APOBEC-A/ERCC2 mutation signatures were associated with good outcome.

TL;DR: In this paper, the authors present guidelines for optimizing workflows to minimize cost and reduce latency in a collaborative genome analysis platform built on a cloud computing infrastructure, including dynamic disk sizing to efficiently utilize virtual disks, tuned provisioning of virtual machines (VMs) using a performance monitoring tool, and utilizing the optimal parallelization of a task9s workload.

TL;DR: Zebrafish modeling and biochemical approaches suggest that truncated RABL3 elevates KRAS activity via accelerated prenylation and uncover a mechanism for dysregulated RAS activity in development and cancer.