Gad Getz

TL;DR: It is demonstrated that KDM4A is regulated by hSA-mir-23a-3p, hsa-Mir-23b-3 p, and hsa -mir-137, which are identified as regulators of TSSG and copy gains of a drug resistance gene.

TL;DR: It is hypothesized that CLL heritability might arise from rare coding variants not analyzed in previous studies, which are largely unexplained by traditional linkage or genome-wide association studies.

TL;DR: In this paper , the authors sequenced whole genomes from 717 normal naive and memory B and T cells and haematopoietic stem cells and found that all lymphocyte subsets carried more point mutations and structural variants than stem cells, with higher burdens in memory cells than in naive cells and with T cells accumulating mutations at a higher rate throughout life.

TL;DR: Lineage sequencing is presented, a new genome sequencing approach that enables somatic event reconstruction by providing quality somatic mutation call sets with resolution as high as the single-cell level in subject lineages and shows that mutations arrive with nonuniform probability across sublineages and that DNA lesion dynamics may cause strong correlations between certain mutations.

TL;DR: The ability to directly determine haplotypes from cancer samples represents an opportunity to expand reference panels of phased chromosomes, which may have general interest in various population genetic applications and may be exploited to interrogate the relationship between germline risk and cancer phenotype with greater sensitivity than is possible using unphased genotype.