G
Gad Getz
Researcher at Broad Institute
Publications - 627
Citations - 309042
Gad Getz is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 189, co-authored 520 publications receiving 247560 citations. Previous affiliations of Gad Getz include University of Colorado Denver & University of California, San Diego.
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Journal ArticleDOI
Erratum: Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity (Nature (2012) 483 7391 (603-607))
Jordi Barretina,Jordi Barretina,Jordi Barretina,Giordano Caponigro,Nicolas Stransky,Kavitha Venkatesan,Adam A. Margolin,Sungjoon Kim,Christine D. Wilson,Joseph Lehar,Gregory V. Kryukov,Dmitriy Sonkin,Anupama Reddy,Manway Liu,Lauren Murray,Michael F. Berger,Michael F. Berger,John Monahan,Paula Morais,Jodi Meltzer,Adam Korejwa,Judit Jané-Valbuena,Judit Jané-Valbuena,Felipa A. Mapa,Joseph Thibault,Eva Bric-Furlong,Pichai Raman,Aaron Shipway,Ingo H. Engels,Jill Cheng,Guoying K. Yu,Jianjun Yu,Peter Aspesi,Melanie de Silva,Kalpana Jagtap,Michael D. Jones,Li Wang,Charlie Hatton,Emanuele Palescandolo,Supriya Gupta,Scott Mahan,Carrie Sougnez,Robert C. Onofrio,Ted Liefeld,Laura E. MacConaill,Wendy Winckler,Michael R. Reich,Nanxin Li,Jill P. Mesirov,Stacey Gabriel,Gad Getz,Kristin G. Ardlie,Vivien W. Chan,Vic E. Myer,Barbara L. Weber,Jeffrey A. Porter,Markus Warmuth,Peter Finan,Jennifer L. Harris,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Michael Morrissey,William R. Sellers,Robert Schlegel,Levi A. Garraway,Levi A. Garraway +66 more
TL;DR: Jordi Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Golub, Michael P. Morais, Jodi Meltzer, Judit Jané-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guoying K. Yu
Journal ArticleDOI
Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.
Lipika Goyal,Supriya K. Saha,Leah Y. Liu,Giulia Siravegna,Ignaty Leshchiner,Leanne G. Ahronian,Jochen K. Lennerz,Phuong Vu,Vikram Deshpande,Avinash Kambadakone,Benedetta Mussolin,Stephanie Reyes,L. Henderson,Jiaoyuan Elisabeth Sun,Emily E. Van Seventer,Joseph M. Gurski,Sabrina Baltschukat,Barbara Schacher-Engstler,Louise Barys,Christelle Stamm,Pascal Furet,David P. Ryan,James R. Stone,A. John Iafrate,Gad Getz,Gad Getz,Diana Graus Porta,Ralph Tiedt,Alberto Bardelli,Dejan Juric,Ryan B. Corcoran,Nabeel Bardeesy,Andrew X. Zhu +32 more
TL;DR: The first genetic mechanisms of clinical acquired resistance to FGFR inhibition in patients with FGFR2 fusion-positive ICC are reported, which can inform future strategies for detecting resistance mechanisms and inducing more durable remissions in ICC and in the wide variety of cancers where the FGFR pathway is being explored as a therapeutic target.
Journal ArticleDOI
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers
Ryan S. Lee,Chip Stewart,Scott L. Carter,Lauren Ambrogio,Kristian Cibulskis,Carrie Sougnez,Michael S. Lawrence,Daniel Auclair,Jaume Mora,Todd R. Golub,Jaclyn A. Biegel,Gad Getz,Charles W. M. Roberts +12 more
TL;DR: In this paper, the authors sequenced the exomes of 35 rhabdoid tumors, highly aggressive cancers of early childhood characterized by biallelic loss of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex.
Journal ArticleDOI
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
Jennifer A. Perry,Adam Kiezun,Peter Tonzi,Eliezer M. Van Allen,Eliezer M. Van Allen,Scott L. Carter,Sylvan C. Baca,Sylvan C. Baca,Glenn S. Cowley,Ami S. Bhatt,Ami S. Bhatt,Esther Rheinbay,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Elena Helman,Elena Helman,Amaro Taylor-Weiner,Aaron McKenna,David S. DeLuca,Michael S. Lawrence,Lauren Ambrogio,Carrie Sougnez,Andrey Sivachenko,Loren D. Walensky,Nikhil Wagle,Jaume Mora,Carmen de Torres,Cinzia Lavarino,Simone dos Santos Aguiar,José Andrés Yunes,Silvia Regina Brandalise,Gabriela Elisa Mercado-Celis,Jorge Melendez-Zajgla,Rocío Cárdenas-Cardós,Liliana Velasco-Hidalgo,Charles W. M. Roberts,Levi A. Garraway,Carlos Rodriguez-Galindo,Stacey Gabriel,Eric S. Lander,Eric S. Lander,Todd R. Golub,Todd R. Golub,Stuart H. Orkin,Stuart H. Orkin,Gad Getz,Gad Getz,Katherine A. Janeway +47 more
TL;DR: In this paper, the authors examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing, and found that only the TP53 gene was mutated at significant frequency across all samples.
Discovery and saturation analysis of cancer genes across 21 tumour types
Michael S. Lawrence,Petar Stojanov,Craig H. Mermel,James T. Robinson,Levi A. Garraway,Todd R. Golub,Matthew Meyerson,Stacey Gabriel,Eric S. Lander,Gad Getz +9 more
TL;DR: In this paper, the authors explored the feasibility of creating a comprehensive catalogue of cancer genes by analyzing exome sequences from 4,742 human cancers and their matched normal-tissue samples across 21 cancer types and found that large-scale genomic analysis can identify nearly all known cancer genes in these tumour types.