G
Gad Getz
Researcher at Broad Institute
Publications - 627
Citations - 309042
Gad Getz is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 189, co-authored 520 publications receiving 247560 citations. Previous affiliations of Gad Getz include University of Colorado Denver & University of California, San Diego.
Papers
More filters
Journal ArticleDOI
Monitoring Plasma Cells and Clonal Emergence through Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma
Ankit K. Dutta,Jean-Baptiste Alberge,Elizabeth Lightbody,Cody J. Boehner,Romanos Sklavenitis-Pistofidis,Amanda Cao,Tarek H. Mouhieddine,Annie Cowan,Nang Kham Su,Andrew Dunford,Erica M Horowitz,Hadley Barr,Jenna B Beckwith,Laura Hevenor,Jacqueline Perry,Ornkleaw Zepp,T. Bui,Steven P. Gross,Omar Nadeem,Chip Stewart,Daniel Auclair,Gad Getz,I R Ghobrial +22 more
TL;DR: MinimuMM-seq as mentioned in this paper is a method for enumeration and whole genome sequencing of CTCs that enables genomic profiling and WGS-based cytogenetic analyses from enriched liquid biopsy samples.
Journal ArticleDOI
Dipg-20. delineating mediators of oncogenesis in foxr2-expressing diffuse midline gliomas
Jessica W. Tsai,Paloma Cejas,Dayle K Wang,Smruti Patel,David W Wu,Phonepasong Arounleut,Xin Wei,Ningxuan Zhou,Sudeepa Syamala,Frank Dubois,Kristine Pelton,Jayne Vogelzang,Cecilia Sousa,Audrey Baguette,Xiaolong Chen,Alexandra Larisa Condurat,S. Dixon-Clarke,Kevin N Zhou,Sophie Lu,Elizabeth Gonzalez,Madison S Chacon,Jeromy J Digiacomo,Rushil Kumbhani,Dana Novikov,Maria Tsoli,David S. Ziegler,Uta Dirksen,N. Jager,Christof M. Kramm,Michaela Nathrath,Stefan S. Bielack,Suzanne J. Baker,Jinghui Zhang,James M. McFarland,Gad Getz,François Aguet,Nada Jabado,Olaf Witt,Stefan M. Pfister,Keith L. Ligon,Volker Hovestadt,Claudia L. Kleinman,Henry W. Long,David T. Jones,Pratiti Bandopadhayay,Timothy N. Phoenix +45 more
TL;DR: In this paper , the authors used an integrative approach using transcriptomics, epigenetics, proteomics, in vitro cancer models, and in vivo mouse models to systematically evaluate how FOXR2 mediates gliomagenesis.
Journal ArticleDOI
Author Correction: The repertoire of mutational signatures in human cancer
Ludmil B. Alexandrov,Jaegil Kim,Nicholas J. Haradhvala,Mi Ni Huang,Alvin Wei Tian Ng,Yang Wu,Arnoud W. A. Boot,Kyle R. Covington,Dmitry A. Gordenin,Erik N. Bergstrom,S M Ashiqul Islam,Nuria Lopez-Bigas,Leszek J. Klimczak,John Russell McPherson,Sandro Morganella,Radhakrishnan Sabarinathan,David A. Wheeler,Ville Mustonen,Gad Getz,S. Rozen,Michael R. Stratton +20 more
Journal ArticleDOI
Reconstructing the Genomic History of Multiple Myeloma Precursor Disease: Novel Insights and Clinical Applicability
Jean-Baptiste Alberge,Ankit K. Dutta,Elizabeth Lightbody,Andrea Poletti,Andrew Dunford,Oliver Priebe,Julian M. Hess,Cody J. Boehner,Romanos Sklavenitis-Pistofidis,Nang Kham Su,Erica M Horowitz,Hadley Barr,Jenna B Beckwith,Laura Hevenor,Katherine Towle,Jacqueline Perry,Esther Rheinbay,Chip Stewart,Gad Getz,Irene M. Ghobrial +19 more
TL;DR: In this article , the authors reported the translational implications of a large-scale characterization of indolent stages of multiple myeloma (MM) after 2 years of follow-up.
Journal ArticleDOI
Abstract 1789: Chromatin modifier alterations confer resistance to endocrine deprivation and CDK4/6 inhibitors in ER+ breast cancer and drive convergent evolution in patient autopsy lesions
Elizaveta S. Leshchiner,Ignaty Leshchiner,Elizabeth E. Martin,Christopher S. Chen,Thomas Zhang,Christopher J. Pinto,Kahn Rhrissorrakrai,Filippo Utro,Chaya Levovitz,Raquel A. Jacobs,Brian P. Danysh,Kara Slowik,Maida Williams Broudo,Laxmi Parida,Dejan Juric,Gad Getz +15 more
TL;DR: It is suggested that KMT2C mutations may be a mechanism of acquired resistance to CDK 4/6 inhibitor combinations, and subsequent treatment with therapies directed towards ER or CDK4/6 pathways may be ineffective and other treatment avenues need to be developed.