Gad Getz

TL;DR: A general method to detect cancer genes based on significant 3D clustering of mutations relative to the structure of the encoded protein products and the results indicate that systematic consideration of 3D structure can assist in the identification of cancer genes and in the understanding of the functional role of their mutations.

TL;DR: The integration of mass spectrometry-based proteomics with next-generation DNA and RNA sequencing profiles tumors more comprehensively underscores the potential of proteogenomics for clinical investigation of breast cancer through more accurate annotation of targetable pathways and biological features of this remarkably heterogeneous malignancy.

TL;DR: It is demonstrated that PD-1 blockade in the context of suboptimal T cell activation engenders a state of non-responsiveness but not when there is strong stimulation by vaccination, which can enhance antitumor responses in a subset of cases.

TL;DR: Fudenberg et al. as mentioned in this paper found that copy number gain and loss is influenced by the three-dimensional organization of the genome in the nucleus, and they used statistical approaches to model different processes.

TL;DR: It is demonstrated that H3K9/36me3 lysine demethylase KDM4A/JMJD2A overexpression leads to localized copy gain of 1q12, 1q21, and Xq13.1 without global chromosome instability.