Gad Getz

TL;DR: Using single-cell RNA sequencing of bone marrow cells from precursor stages, MGUS and smoldering myeloma (SMM), to full-blown MM alongside healthy donors, this work demonstrates early immune changes during patient progression.

TL;DR: These studies reveal the complex evolutionary trajectories occurring across individual hematological malignancies and suggest that while clonal evolution may contribute to resistance to therapy, treatment may also hasten the evolutionary process.

TL;DR: The oncogenic nature of mutations observed in FGFR2 and FGFR3, each of which are observed in 3% of samples, are described, for a mutation rate of 6% across both genes.

TL;DR: PRADA is a flexible, modular and highly scalable software platform that provides many different types of information available by multifaceted analysis starting from raw paired-end RNA-seq data: gene expression levels, quality metrics, detection of unsupervised and supervised fusion transcripts, Detection of intragenic fusion variants, homology scores and fusion frame classification.

TL;DR: In this paper, the authors identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions.