G
Gad Getz
Researcher at Broad Institute
Publications - 627
Citations - 309042
Gad Getz is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 189, co-authored 520 publications receiving 247560 citations. Previous affiliations of Gad Getz include University of Colorado Denver & University of California, San Diego.
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Journal ArticleDOI
High-resolution profiling of lung adenocarcinoma identifies expression subtypes with specific biomarkers and clinically relevant vulnerabilities.
Whijae Roh,Yifat Geffen,Hongui Cha,Mendy L. Miller,Shankara Anand,Jaegil Kim,David I. Heiman,Justin F. Gainor,Peter W. Laird,Andrew D. Cherniack,Chan Young Ock,Se-Hoon Lee,Gad Getz +12 more
TL;DR: A consensus hierarchical clustering approach was utilized on 509 LUAD cases from The Cancer Genome Atlas to identify robust tumor expression subtypes, and subsequent integrative analysis of genomics, proteomics, and CRISPR screening data revealed subtype-specific biology and vulnerabilities.
Posted ContentDOI
Expanding discovery from cancer genomes by integrating protein network analyses with in vivo tumorigenesis assays
Heiko Horn,Michael S. Lawrence,Candace R. Chouinard,Yashaswi Shrestha,Jessica Xin Hu,Elizabeth Worstell,Emily Shea,Nina Ilic,Eejung Kim,Atanas Kamburov,Alireza Kashani,Joshua D. Campbell,William C. Hahn,Jesse S. Boehm,Gad Getz,Kasper Lage +15 more
TL;DR: A robust statistic (NetSig) that integrates protein interaction networks and data from 4,742 tumor exomes is developed and used to accurately classify known driver genes in 60% of tested tumor types and to predict 62 new candidates.
Proceedings ArticleDOI
Abstract 1279: Passenger mutation landscape in cancer genomes
Sushant Kumar,Jonathan Warrel,Patrick McGillivray,William Meyerson,Shantao Li,Leonidas Salichos,Arif Harmanci,Alexander Martinez Fundichely,Calvin Wing Yiu Chan,Carl Herrmann,Morten Nielsen,Lucas Lochovsky,Yan Zhang,Xiaotong Li,Ekta Khurana,Gad Getz,Mark Gerstein +16 more
TL;DR: It is shown that disruption of genetic regulatory elements in the noncoding genome correlates with altered gene expression, and overall functional burdening of various genomic elements correlate with patient survival time, and tumor clonality.
Journal ArticleDOI
Whole Genome Sequencing Identifies Functional Mutations In the Wnt Pathway In CLL
Lili Wang,Nathalie Pochet,Kristian Cibulskis,Wandi Zhang,Michael S. Lawrence,Quinlan L. Sievers,Erica Shefler,Donna Neuberg,Stacey Gabriel,Carrie Sougnez,Aviv Regev,Gad Getz,Nir Hacohen,Jennifer R. Brown,Catherine J. Wu +14 more
TL;DR: It is confirmed that the Wnt pathway is in fact highly dysregulated in CLL based on gene expression analysis of 141Wnt pathway members, and it is demonstrated that Wnt pathways activation and dysregulation contributes to CLL survival.
Proceedings ArticleDOI
Abstract NG03: Genomic characterization of 101 brain metastases and paired primary tumors reveals patterns of clonal evolution and selection of driver mutations
Priscilla K. Brastianos,Scott L. Carter,Sandro Santagata,Amaro Taylor-Weiner,Robert T. Jones,Peleg M. Horowitz,Keith L. Ligon,Joan Seaone,Elena Martínez-Sáez,Josep Tabernero,Daniel P. Cahill,Sun-Ha Paek,Ian F. Dunn,Bruce E. Johnson,Toni K. Choueiri,Michael S. Rabin,Eric P. Winer,Nan Lin,Paul Van Hummelen,Anat Stemmer-Rachamimov,Rameen Beroukhim,David L. Louis,Tracy T. Batchelor,José Baselga,Gad Getz,William C. Hahn +25 more
TL;DR: The largest massively parallel sequencing study to date of matched brain metastases and primary tumors uses intratumoral heterogeneity estimates to elucidate the evolutionary patterns observed in the process of metastasis and suggests that single biopsies do not capture the heterogeneity within patients.