G
Gad Getz
Researcher at Broad Institute
Publications - 627
Citations - 309042
Gad Getz is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 189, co-authored 520 publications receiving 247560 citations. Previous affiliations of Gad Getz include University of Colorado Denver & University of California, San Diego.
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Journal ArticleDOI
Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer.
Alok K. Tewari,Alok K. Tewari,Alexander T. M. Cheung,Alexander T. M. Cheung,Jett Crowdis,Jett Crowdis,Jake Conway,Jake Conway,Sabrina Y. Camp,Sabrina Y. Camp,Stephanie A. Wankowicz,Stephanie A. Wankowicz,Dimitri Livitz,Jihye Park,Jihye Park,Rosina T. Lis,Alice Bosma-Moody,Alice Bosma-Moody,Meng Xiao He,Meng Xiao He,Saud H. AlDubayan,Saud H. AlDubayan,Saud H. AlDubayan,Zhenwei Zhang,Rana R. McKay,Ignaty Leshchiner,Myles Brown,Steven P. Balk,Gad Getz,Gad Getz,Mary-Ellen Taplin,Eliezer M. Van Allen,Eliezer M. Van Allen +32 more
TL;DR: In this article, the authors performed whole-exome and transcriptome sequencing on pre-treatment multi-regional tumor biopsies from exceptional responders (ERs) and non-responders (NRs, pathologic T3 or lymph node-positive disease) to intensive neoadjuvant anti-androgen therapies.
Posted ContentDOI
APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer
H. Isozaki,A. Abbasi,N. Nikpour,Adam Langenbucher,Wenjia Su,Marcello Stanzione,Heidie Frisco-Cabanos,Faria M. Siddiqui,Nicole Phan,Pégah Jalili,S. Oh,Daria Timonina,Samantha J. Bilton,Maria Gomez-Caraballo,Hannah L. Archibald,Varuna Nangia,K. Dionne,Amanda K. Riley,Michael W. Lawlor,Mandeep Banwait,Rosemary Cobb,Lee Zou,Nicholas J. Dyson,Christopher J. Ott,Christopher J. Ott,Cyril H. Benes,Gad Getz,Cheong Xin Chan,Alice T. Shaw,Alice T. Shaw,Jiachen Lin,Jiachen Lin,L.V. Sequist,L.V. Sequist,Zofia Piotrowska,Jeffrey A. Engelman,Jaewon J. Lee,Yosef E. Maruvka,Rémi Buisson,Michael S. Lawrence,Michael S. Lawrence,Aaron N. Hata +41 more
TL;DR: In this article, the authors report that lung cancer targeted therapies commonly used in the clinic induce the expression of cytidine deaminase APOBEC3A (A3A), leading to sustained mutagenesis in drug-tolerant cancer cells persisting during therapy.
Journal ArticleDOI
Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma
Lawrence N. Kwong,Lihua Zou,Sharmeen Chagani,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Mingguang Liu,Shan Jiang,Alexei Protopopov,Jianhua Zhang,Gad Getz,Lynda Chin +10 more
TL;DR: Assessment of tumor initiation and therapy resistance bottlenecks in mouse models of melanoma, with or without genomic instability, demonstrates how different selection pressures can interact with genomic instability to impact tumor evolution.
Supplementary Notes MicroRNA Expression Profiles Classify Human Cancers
Jun Lu,Gad Getz,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Benjamin L. Ebert,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,Todd R. Golub +11 more
Journal ArticleDOI
Identification of somatically acquired BRCA1/2 mutations by cfDNA analysis in patients with metastatic breast cancer
Neelima Vidula,Taronish D. Dubash,Michael S. Lawrence,Antoine Simoneau,Andrzej Niemierko,Erica Blouch,Becky Nagy,Whijae Roh,Brian Chirn,Brittany A. Reeves,Giuliana Malvarosa,Jochen K. Lennerz,Steven J. Isakoff,Dejan Juric,Douglas S. Micalizzi,Seth A. Wander,Laura Spring,Beverly Moy,Kristen M. Shannon,Jerry Younger,Richard B. Lanman,Mehmet Toner,A. John Iafrate,Gad Getz,Lee Zou,Leif W. Ellisen,Shyamala Maheswaran,Daniel A. Haber,Aditya Bardia +28 more
TL;DR: Somatic BRCA1/2 mutations are readily detectable in MBC by cfDNA analysis, and may be present as both known germline pathogenic and novel variants.