G
Gad Getz
Researcher at Broad Institute
Publications - 627
Citations - 309042
Gad Getz is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 189, co-authored 520 publications receiving 247560 citations. Previous affiliations of Gad Getz include University of Colorado Denver & University of California, San Diego.
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Journal ArticleDOI
Molecular and genetic properties of tumors associated with local immune cytolytic activity.
TL;DR: The genetic findings provide evidence for immunoediting in tumors and uncover mechanisms of tumor-intrinsic resistance to cytolytic activity, suggesting immune-mediated elimination.
Journal ArticleDOI
Discovery and saturation analysis of cancer genes across 21 tumour types
Michael S. Lawrence,Petar Stojanov,Craig H. Mermel,James T. Robinson,Levi A. Garraway,Todd R. Golub,Matthew Meyerson,Stacey Gabriel,Eric S. Lander,Gad Getz +9 more
TL;DR: It is found that large-scale genomic analysis can identify nearly all known cancer genes in these cancer types and 33 genes that were not previously known to be significantly mutated in cancer, including genes related to proliferation, apoptosis, genome stability, chromatin regulation, immune evasion, RNA processing and protein homeostasis.
Journal ArticleDOI
Comprehensivemolecular characterization of clear cell renal cell carcinoma
Chad J. Creighton,Margaret Morgan,Preethi H. Gunaratne,Preethi H. Gunaratne,David A. Wheeler,Richard A. Gibbs,Gordon Robertson,Andy Chu,Rameen Beroukhim,Kristian Cibulskis,Sabina Signoretti,Fabio Vandin,Hsin-Ta Wu,Benjamin J. Raphael,Roel G.W. Verhaak,Pheroze Tamboli,Wandaliz Torres-Garcia,Rehan Akbani,John N. Weinstein,Victor E. Reuter,James J. Hsieh,A. Rose Brannon,A. Ari Hakimi,Anders Jacobsen,Giovanni Ciriello,Boris Reva,Christopher J. Ricketts,W. Marston Linehan,Joshua M. Stuart,W. Kimryn Rathmell,Shen Hui,Peter W. Laird,Donna M. Muzny,Caleb F. Davis,Xi Liu,Kyle Chang,Nipun Kakkar,Lisa R. Trevino,Susan M. Benton,Jeffrey G. Reid,Donna Morton,Harsha Doddapaneni,Han Yi,Lora Lewis,Dinh Huyen,Christie Kovar,Yiming Zhu,Jireh Santibanez,Wang Min,Walker Hale,Divya Kalra,Gad Getz,Michael S. Lawrence,Carrie Sougnez,Scott L. Carter,Andrey Sivachenko,Lichtenstein Lee,Chip Stewart,Doug Voet,Sheila Fisher,Stacey Gabriel,Eric S. Lander,Steve Schumacher,Barbara Tabak,Gordon Saksena,Robert C. Onofrio,Andrew D. Cherniack,Jeff Gentry,Kristin G. Ardlie,Matthew Meyerson,Hye Jung E. Chun,Andrew J. Mungall,Payal Sipahimalani,Dominik Stoll,Adrian Ally,Miruna Balasundaram,Yaron S.N. Butterfield,Rebecca Carlsen,Candace Carter,Eric Chuah,Robin J.N. Coope,Noreen Dhalla,Sharon M. Gorski,Ranabir Guin,Carrie Hirst,Martin Hirst,Robert A. Holt,Chandra Lebovitz,Darlene Lee,Haiyan I. Li,Michael Mayo,Richard A. Moore,Erin Pleasance,Patrick Plettner,Jacqueline E. Schein,Arash Shafiei,Jared R. Slobodan,Angela Tam,Nina Thiessen,Richard Varhol,Natasja Wye,Yongjun Zhao,Inanc Birol,Steven J.M. Jones,Marco A. Marra,J. Todd Auman,Donghui Tan,Corbin D. Jones,Katherine A. Hoadley,Piotr A. Mieczkowski,Lisle E. Mose,Stuart R. Jefferys,Michael D. Topal,Christina Liquori,Yidi J. Turman,Shi Yan,Scot Waring,Elizabeth Buda,Jesse Walsh,Junyuan Wu,Tom Bodenheimer,Alan P. Hoyle,Janae V. Simons,Mathew G. Soloway,Saianand Balu,Joel S. Parker,D. Neil Hayes,Charles M. Perou,Raju Kucherlapati,Peter J. Park,Timothy J. Triche,Daniel J. Weisenberger,Phillip H. Lai,Moiz S. Bootwalla,Dennis T. Maglinte,Swapna Mahurkar,Benjamin P. Berman,David Van Den Berg,Leslie Cope,Stephen B. Baylin,Michael S. Noble,Daniel DiCara,Hailei Zhang,Juok Cho,David I. Heiman,Nils Gehlenborg,William Mallard,Lin Pei,Scott Frazer,Petar Stojanov,Yingchun Liu,Lihua Zhou,Jaegil Kim,Lynda Chin,Lynda Chin,Christopher C. Benz,Christina Yau,Sheila Reynolds,Ilya Shmulevich,Rahul Vegesna,Hoon Kim,Zhang Wei,David Cogdell,Eric Jonasch,Zhiyong Ding,Yiling Lu,Nianxiang Zhang,Anna K. Unruh,Tod D. Casasent,Chris Wakefield,Dimitra Tsavachidou,Gordon B. Mills,Jianjiong Gao,Ethan Cerami,Benjamin Gross,B. Arman Aksoy,Rileen Sinha,Nils Weinhold,S. Onur Sumer,Barry S. Taylor,Ronglai Shen,Irina Ostrovnaya,Michael F. Berger,Marc Ladanyi,Chris Sander,Suzanne S. Fei,Andrew J. Stout,Paul T. Spellman,Daniel L. Rubin,Tiffany Ting Liu,Ng Sam,Evan O. Paull,Daniel E. Carlin,Theodore C. Goldstein,Peter Waltman,Kyle Ellrott,Zhu Jing,David Haussler,Weimin Xiao,Candace Shelton,Johanna Gardner,Robert Penny,Mark E. Sherman,David Mallery,Scott Morris,Joseph Paulauskis,Ken Burnett,Troy Shelton,William G. Kaelin,William G. Kaelin,Toni K. Choueiri,Michael B. Atkins,Erin Curley,Satish K. Tickoo,Leigh B. Thorne,Lori Boice,Huang Mei,Jennifer C. Fisher,Cathy D. Vocke,James Peterson,Robert Worrell,Maria J. Merino,Laura S. Schmidt,Laura S. Schmidt,Bogdan Czerniak,Kenneth Aldape,Christopher G. Wood,Jeff Boyd,Jo Ellen Weaver,Mary Iacocca,Nicholas J. Petrelli,Gary Witkin,Jennifer Brown,Christine Czerwinski,Lori Huelsenbeck-Dill,Brenda Rabeno,Jerome Myers,Carl Morrison,Julie Bergsten,John Eckman,Jodi Harr,Christine I. Smith,Kelinda Tucker,Leigh Anne Zach,Wiam Bshara,Carmelo Gaudioso,Rajiv Dhir,Jodi K. Maranchie,Joel B. Nelson,Anil V. Parwani,Cureline Olga Potapova,Konstantin V. Fedosenko,John C. Cheville,R. Houston Thompson,Juan M. Mosquera,Mark A. Rubin,Michael L. Blute,Todd Pihl,Mark A. Jensen,Robert Sfeir,Ari B. Kahn,Anna Chu,Prachi Kothiyal,Eric E. Snyder,Joan Pontius,Brenda Ayala,Mark Backus,Jessica Walton,Julien Baboud,Dominique L. Berton,Matthew C. Nicholls,Deepak Srinivasan,Rohini Raman,Stanley Girshik,Peter A. Kigonya,Shelley Alonso,Rashmi N. Sanbhadti,Sean P. Barletta,David Pot,Margi Sheth,John A. Demchok,Tanja Davidsen,Zhining Wang,Liming Yang,Roy Tarnuzzer,Jiashan Zhang,Greg Eley,Martin L. Ferguson,Kenna R. Mills Shaw,Mark S. Guyer,Bradley A. Ozenberger,Heidi J. Sofia +291 more
TL;DR: Remodelling cellular metabolism constitutes a recurrent pattern in ccRCC that correlates with tumour stage and severity and offers new views on the opportunities for disease treatment.
Integrated genomic characterization of endometrial carcinoma
Gad Getz,Stacey Gabriel,Kristian Cibulskis,Eric S. Lander,Andrey Sivachenko,Carrie Sougnez,Michael S. Lawrence,Cyriac Kandoth,David J. Dooling,Robert S. Fulton,Lucinda Fulton,Joelle Kalicki-Veizer,Michael D. McLellan,Michelle O'Laughlin,Heather Schmidt,Richard K. Wilson,Kai Ye,Li Ding,Elaine R. Mardis,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S. Butterfield,Rebecca Carlsen,Candace D. Carter,Andy Chu,Eric Chuah,Hye Jung E. Chun,Noreen Dhalla,Ranabir Guin,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Patrick Plettner,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Richard Varhol,A. Gordon Robertson,Andrew D. Cherniack,Itai Pashtan,Gordon Saksena,Robert C. Onofrio,Steven E. Schumacher,Barbara Tabak,Scott L. Carter,Bryan Hernandez,Jeff Gentry,Helga B. Salvesen,Kristin Ardlie,Wendy Winckler,Rameen Beroukhim,Matthew Meyerson,Angela Hadjipanayis,Semin Lee,Harshad S. Mahadeshwar,Peter J. Park,Alexei Protopopov,Xiaojia Ren,Sahil Seth,Xingzhi Song,Jiabin Tang,Ruibin Xi,Lixing Yang,Dong Zeng,Raju Kucherlapati,Lynda Chin,Jianhua Zhang,J. Todd Auman,Saianand Balu,Tom Bodenheimer,Elizabeth Buda,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jefferys,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Lisle E. Mose,Joel S. Parker,Charles M. Perou,Jeff Roach,Yan Shi,Janae V. Simons,Mathew G. Soloway,Donghui Tan,Michael D. Topal,Scot Waring,Junyuan Wu,Katherine A. Hoadley,Stephen B. Baylin,Moiz S. Bootwalla,Phillip H. Lai,Timothy J. Triche,David Van Den Berg,Daniel J. Weisenberger,Peter W. Laird,Hui Shen,Juok Cho,Daniel DiCara,Scott Frazer,David I. Heiman,Rui Jing,Pei Lin,Will Mallard,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Michael S. Noble,Sheila M. Reynolds,Ilya Shmulevich,B. Arman Aksoy,Yevgeniy Antipin,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,Marc Ladanyi,Boris Reva,Chris Sander,Rileen Sinha,S. Onur Sumer,Barry S. Taylor,Ethan Cerami,Nils Weinhold,Nikolaus Schultz,Ronglai Shen,Stephen C. Benz,Theodore C. Goldstein,David Haussler,Sam Ng,Christopher Szeto,Joshua M. Stuart,Christopher C. Benz,Christina Yau,Wei Zhang,Matti Annala,Bradley M. Broom,Tod D. Casasent,Zhenlin Ju,Han Liang,Guoyan Liu,Yiling Lu,Anna K. Unruh,Chris Wakefield,John N. Weinstein,Nianxiang Zhang,Yuexin Liu,Russell Broaddus,Rehan Akbani,Gordon B. Mills,Christopher Adams,Thomas Barr,Aaron D. Black,Jay Bowen,John Deardurff,Jessica Frick,Julie M. Gastier-Foster,Thomas Grossman,Hollie A. Harper,Melissa Hart-Kothari,Carmen Helsel,Aaron Hobensack,Harkness Kuck,Kelley Kneile,Kristen M. Leraas,Tara M. Lichtenberg,Cynthia McAllister,Robert E. Pyatt,Nilsa C. Ramirez,Teresa R. Tabler,Nathan Vanhoose,Peter White,Lisa Wise,Erik Zmuda,Nandita Barnabas,Charlenia Berry-Green,Victoria Blanc,Lori Boice,Michael Button,Adam M. Farkas,Alexander A. Green,Jean MacKenzie,Dana Nicholson,Steve E. Kalloger,C Blake Gilks,Beth Y. Karlan,Jenny Lester,Sandra Orsulic,Mark L. Borowsky,Mark G. Cadungog,Christine Czerwinski,Lori Huelsenbeck-Dill,Mary Iacocca,Nicholas J. Petrelli,Brenda Rabeno,Gary Witkin,Elena Nemirovich-Danchenko,Olga Potapova,D L Rotin,Andrew Berchuck,Michael J. Birrer,P.J. DiSaia,Laura Monovich,Erin Curley,Johanna Gardner,David Mallery,Robert Penny,Sean C. Dowdy,Boris Winterhoff,Linda Dao,Bobbie S. Gostout,Alexandra Meuter,Attila Teoman,Fanny Dao,Narciso Olvera,Faina Bogomolniy,Karuna Garg,Robert A. Soslow,Douglas A. Levine,Mikhail Abramov,John M. S. Bartlett,Sugy Kodeeswaran,Jeremy Parfitt,Fedor Moiseenko,Blaise A. Clarke,Marc T. Goodman,Michael E. Carney,Rayna K. Matsuno,Jennifer C. Fisher,Mei Huang,W. Kimryn Rathmell,Leigh B. Thorne,Linda Van Le,Rajiv Dhir,Robert R. Edwards,Esther Elishaev,Kristin K. Zorn,Paul J. Goodfellow,David G. Mutch,Ari B. Kahn,Daphne W. Bell,Pamela M. Pollock,Chen Wang,David A. Wheeler,Eve Shinbrot,Brenda Ayala,Anna L. Chu,Mark A. Jensen,Prachi Kothiyal,Todd Pihl,Joan Pontius,David A. Pot,Eric E. Snyder,Deepak Srinivasan,Kenna R. Mills Shaw,Margi Sheth,Tanja Davidsen,Greg Eley Martin L. Ferguson,John A. Demchok,Liming Yang,Mark S. Guyer,Bradley A. Ozenberger,Heidi J. Sofia +271 more
TL;DR: The genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours, and these features are classified into four categories: POLE ultramutated, microsatellite instability hypermutated, copy- number low, and copy-number high.
Journal ArticleDOI
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers.
Craig H. Mermel,Steven E. Schumacher,Barbara Hill,Matthew Meyerson,Rameen Beroukhim,Gad Getz +5 more
TL;DR: By separating SCNA profiles into underlying arm-level and focal alterations, the estimation of background rates for each category is improved, and a probabilistic method for defining the boundaries of selected-for SCNA regions with user-defined confidence is described.