G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
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Journal ArticleDOI
Prostaglandins and Inflammation
TL;DR: ins biology has potential clinical relevance for atherosclerosis, the response to vascular injury and aortic aneurysm, and the roles of individual mediators and their receptors in modulating the inflammatory response.
Journal ArticleDOI
The coxibs, selective inhibitors of cyclooxygenase-2.
TL;DR: Development of the coxibs, a new group of antiinflammatory drugs, represents a response to the unsatisfactory therapeutic profile of NSAIDs.
Journal ArticleDOI
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: Meta-analyses of individual participant data from randomised trials
Colin Baigent,Neeraj Bhala,Jonathan Emberson,A Merhi,S. Abramson,Nadir Arber,John A. Baron,Claire Bombardier,Christopher P. Cannon,Michael E. Farkouh,Garret A. FitzGerald,Paul E. Goss,Heather Halls,Ernest T. Hawk,Christopher J. Hawkey,C H Hennekens,Marc C. Hochberg,Lisa Holland,Patricia M. Kearney,Loren Laine,Angel Lanas,Peter Lance,Andreas Laupacis,Jim C. Oates,Carlo Patrono,Thomas J. Schnitzer,Scott D. Solomon,Peter Tugwell,Kate Wilson,Janet Wittes,O. Adelowo,P. Aisen,Abdulaziz A Al-Quorain,Roy D. Altman,George L. Bakris,H. Baumgartner,C. Bresee,M. Carducci,D. M. Chang,C. T. Chou,D. Clegg,M. Cudkowicz,L. Doody,Y. El Miedany,Claire Falandry,J. Farley,Leslie G. Ford,M. Garcia-Losa,M. Gonzalez-Ortiz,M. Haghighi,M. Hala,T. Iwama,Zrinka Jajić,David J. Kerr,H. S. Kim,C.-H. Köhne,B. K. Koo,Barbara K. Martin,Curtis L. Meinert,N. Muller,G. Myklebust,D. Neustadt,R. Omdal,S. Ozgocmen,A. Papas,Paola Patrignani,F. Pelliccia,V. Roy,I. Schlegelmilch,Asad Umar,O. Wahlstrom,F. Wollheim,S. Yocum,X. Y. Zhang,E. Hall,Patricia McGettigan,R Midgley,R. A. Moore,R. Philipson,Sean P. Curtis,Alise S. Reicin,John H. Bond,Ami R. Moore,M. Essex,J. Fabule,B. Morrison,Leslie Tive,Kelly Davies,F. Yau +88 more
TL;DR: Although NSAIDs increase vascular and gastrointestinal risks, the size of these risks can be predicted, which could help guide clinical decision making.
Journal ArticleDOI
Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin
Francesca Catella-Lawson,Muredach P. Reilly,Shiv Kapoor,Andrew J. Cucchiara,Susan DeMarco,Barbara Tournier,Sachin N. Vyas,Garret A. FitzGerald +7 more
TL;DR: The concomitant administration of ibuprofen but not rofecoxib, acetaminophen, or diclofenac antagonizes the irreversible platelet inhibition induced by aspirin, which may limit the cardioprotective effects of aspirin.
Journal ArticleDOI
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2.
B. F. McAdam,Francesca Catella-Lawson,I. A. Mardini,Shiv Kapoor,John A. Lawson,Garret A. FitzGerald +5 more
TL;DR: In this paper, the effects of celecoxib on indices of COX-1-dependent platelet thromboxane (Tx) A2 and on systemic biosynthesis of prostacyclin in vivo were examined.