Grace Murilla

TL;DR: The sequence and annotation of the 366-megabase Glossina mors Titans morsitans genome are described, providing a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

TL;DR: Progress in the development of diamidines for the treatment of HAT is discussed and a new generation of compounds that can penetrate the CNS are discussed.

TL;DR: Tests in cattle are described that may be used to determine the efficacy of recommended curative doses of trypanocidal drugs for the treatment of infection with individual trypanosome isolates, including Trypanosoma vivax, which is rarely infective for mice.

TL;DR: The tsetse populations analyzed differed in the prevalence of symbionts, despite being sympatric and therefore exposed to identical environmental factors, and there were too few natural co-infections detected with the Sodalis and trypanosomes to suggest extensive inter-relations between these infections in natural populations.

TL;DR: It was demonstrated that pafuramidine was orally active in monkeys with early-stage T. brucei rhodesiense infections at dose rates above 3 mg/kg for 5 days, indicating the limited ability of the molecule to cross the blood-brain barrier.