J
James Arthos
Researcher at National Institutes of Health
Publications - 141
Citations - 13478
James Arthos is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Antibody. The author has an hindex of 52, co-authored 134 publications receiving 12693 citations. Previous affiliations of James Arthos include Columbia University & Government of the United States of America.
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Journal ArticleDOI
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.
Alexandra Trkola,Tatjana Dragic,James Arthos,James M. Binley,William C. Olson,Graham P. Allaway,Cecilia Cheng-Mayer,James E. Robinson,Paul J. Maddon,John P. Moore +9 more
TL;DR: CD4 binding, although not absolutely necessary for the gp120–CCR-5 interaction, greatly increases its efficiency, and interference with HIV-1 binding to one or both of its receptors (CD4 and CCR-5) may be an important mechanism of virus neutralization.
Journal ArticleDOI
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
Peter D. Kwong,Peter D. Kwong,Michael L. Doyle,Michael L. Doyle,David J. Casper,Claudia Cicala,Stephanie A. Leavitt,Shahzad Majeed,Shahzad Majeed,Tavis D. Steenbeke,Miro Venturi,Irwin Chaiken,Michael Fung,Hermann Katinger,Paul W. I. H. Parren,James E. Robinson,Donald Van Ryk,Liping Wang,Dennis R. Burton,Ernesto Freire,Richard T. Wyatt,Richard T. Wyatt,Joseph Sodroski,Wayne A. Hendrickson,Wayne A. Hendrickson,James Arthos +25 more
TL;DR: It is shown that recognition by receptor-binding-site antibodies induces conformational change, and conformational masking enables HIV-1 to maintain receptor binding and simultaneously to resist neutralization.
Journal ArticleDOI
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
Jason S. McLellan,Marie Pancera,Chris Carrico,Jason Gorman,Jean-Philippe Julien,Reza Khayat,Robert K. Louder,Robert Pejchal,Mallika Sastry,Kaifan Dai,Sijy O'Dell,Nikita Patel,Syed Shahzad-ul-Hussan,Yongping Yang,Baoshan Zhang,Tongqing Zhou,Jiang Zhu,Jeffrey C. Boyington,Gwo-Yu Chuang,Devan Diwanji,Ivelin S. Georgiev,Young Do Kwon,Doyung Lee,Mark K. Louder,Stephanie Moquin,Stephen D. Schmidt,Zhi Yong Yang,Mattia Bonsignori,John A. Crump,John A. Crump,Saidi Kapiga,Noel E. Sam,Barton F. Haynes,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Laura M. Walker,Sanjay Phogat,Richard T. Wyatt,Jared Orwenyo,Lai-Xi Wang,James Arthos,Carole A. Bewley,John R. Mascola,Gary J. Nabel,William R. Schief,William R. Schief,Andrew B. Ward,Ian A. Wilson,Peter D. Kwong +49 more
TL;DR: The structure of V1/V2 in complex with PG9 is reported, identifying a paradigm of antibody recognition for highly glycosylated antigens, which—with PG9—involves a site of vulnerability comprising just two glycans and a strand.
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Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Tongqing Zhou,Ling Xu,Barna Dey,Ann J. Hessell,Donald Van Ryk,Shi Hua Xiang,Xinzhen Yang,Mei-Yun Zhang,Michael B. Zwick,James Arthos,Dennis R. Burton,Dimiter S. Dimitrov,Joseph Sodroski,Richard T. Wyatt,Gary J. Nabel,Peter D. Kwong +15 more
TL;DR: A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.
Journal ArticleDOI
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
Susan Moir,Jason Ho,Angela Malaspina,Wei-wei Wang,Angela C. DiPoto,Marie A. O'Shea,Gregg Roby,Shyam Kottilil,James Arthos,Michael A. Proschan,Tae-Wook Chun,Anthony S. Fauci +11 more
TL;DR: HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals, and strikingly, HIV- specific responses were enriched in these exhausted tissuelike memory B cells, whereas total immunoglobulin and influenza-specific responses were enrichment in classical memory B Cells.