J
Jenny Chang-Claude
Researcher at German Cancer Research Center
Publications - 24
Citations - 773
Jenny Chang-Claude is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 12, co-authored 24 publications receiving 706 citations. Previous affiliations of Jenny Chang-Claude include University of Hamburg & Kaiser Permanente.
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Journal ArticleDOI
A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability.
Catherine S. Healey,Alison M. Dunning,Teare,D S Chase,Louise Parker,John Burn,Jenny Chang-Claude,Arto Mannermaa,Kataja,David G. Huntsman,Paul D.P. Pharoah,Robert Luben,Doug Easton,B. A. J. Ponder +13 more
TL;DR: A common human polymorphism (N372H) in exon 10 of BRCA2 confers an increased risk of breast cancer: the HH homozygotes have a 1.31-fold (95% CI, 1.07–1.61) greater risk than the NN group.
Journal ArticleDOI
Estimating the heritability of colorectal cancer
Shuo Jiao,Ulrike Peters,Sonja I. Berndt,Hermann Brenner,Katja Butterbach,Bette J. Caan,Christopher S. Carlson,Christopher S. Carlson,Christopher S. Carlson,Andrew T. Chan,Jenny Chang-Claude,Stephen J. Chanock,Keith R. Curtis,David J. Duggan,Jian Gong,Tabitha A. Harrison,Richard B. Hayes,Brian E. Henderson,Michael Hoffmeister,Laurence N. Kolonel,Loic Le Marchand,John D. Potter,Anja Rudolph,Robert E. Schoen,Daniela Seminara,Martha L. Slattery,Emily White,Li Hsu,Li Hsu +28 more
TL;DR: The results suggest that known CRC SNPs only explain a small proportion of the heritability and more common SNPs have yet to be identified.
Journal ArticleDOI
Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium
Deborah J. Thompson,Csilla Szabo,Jon Mangion,Rogier A. Oldenburg,Fabrice Odefrey,Sheila Seal,Rita Barfoot,Karin Kroeze-Jansema,Dawn Teare,Nazneen Rahman,Helene Renard,Graham J. Mann,John L. Hopper,Saundra S. Buys,Irene L. Andrulis,Ruby T. Senie,Mary B. Daly,Dee West,Dee West,Elaine A. Ostrander,Kenneth Offit,Tamar Peretz,Ana Osorio,Javier Benitez,Katherine L. Nathanson,Olga M. Sinilnikova,E. Olah,Yves-Jean Bignon,Pablo Ruiz,Michael D. Badzioch,Hans F. A. Vasen,Andrew Futreal,Catherine M. Phelan,Steven A. Narod,Henry T. Lynch,Bruce A.J. Ponder,Ros Eeles,Hanne Meijers-Heijboer,Dominique Stoppa-Lyonnet,Fergus J. Couch,Diana Eccles,D. Gareth Evans,Jenny Chang-Claude,Gilbert M. Lenoir,Barbara L. Weber,Peter Devilee,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +48 more
TL;DR: It is concluded that, if a susceptibility gene does exist at this locus, it can only account for a small proportion of non-BRCA1/2 families with multiple cases of early-onset breast cancer.
Journal Article
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations : Cancer Research
Gordon Fehringer,P. Kraft,Paul D.P. Pharoah,Rosalind A. Eeles,Nilanjan Chatterjee,Fredrick R. Schumacher,Joellen M. Schildkraut,S. Lindstrom,Paul Brennan,Heike Bickeböller,Richard S. Houlston,M. T. Landi,Neil E. Caporaso,Angela Risch,A A Al Olama,Sonja I. Berndt,Edward Giovannucci,Henrik Grönberg,Zsofia Kote-Jarai,Jun Ma,Kenneth Muir,Meir J. Stampfer,Victoria L. Stevens,Fredrik Wiklund,Walter C. Willett,Ellen L. Goode,Jennifer B. Permuth,Harvey A. Risch,Brett M. Reid,Stéphane Bézieau,Hermann Brenner,T.A. Chan,Jenny Chang-Claude,Thomas J. Hudson,J. K. Kocarnik,Polly A. Newcomb,Robert E. Schoen,Martha L. Slattery,Emily White,Muriel A. Adank,Habibul Ahsan,Kristiina Aittomäki,Laura Baglietto,Carl Blomquist,Federico Canzian,Kamila Czene,I dos Santos Silva,A. H. Eliassen,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,M Garcia-Closas,Mia M. Gaudet,Nichola Johnson,Per Hall,Aditi Hazra,Rebecca Hein,A. Hofman,John L. Hopper,Astrid K. Irwanto,Mattias Johansson,Rudolph Kaaks,Muhammad G. Kibriya,Peter Lichtner,Jianjun Liu,Eiliv Lund,Enes Makalic,A. Meindl,Bertram Müller-Myhsok,Taru A. Muranen,Heli Nevanlinna,Petra H.M. Peeters,J. Peto,Ross L. Prentice,Nazneen Rahman,Anthony M. J. Sanchez,Daniel F. Schmidt,Rita K. Schmutzler,Melissa C. Southey,Rulla M. Tamimi,Ruth C. Travis,Clare Turnbull,Andre G. Uitterlinden,M. Z. Wang,Alice S. Whittemore,Xiaohong R. Yang,Wei Zheng,Daniel D. Buchanan,Graham Casey,David V. Conti,Christopher K. Edlund,Steve Gallinger,Robert W. Haile,Mark A. Jenkins,Loic Le Marchand,Li Li,N. M. Lindor,Stephanie L. Schmit,Stephen N. Thibodeau,Michael O. Woods,Thorunn Rafnar,Julius Gudmundsson,Simon N. Stacey,K. Stefansson,Patrick Sulem,A.Y. Chen,Jonathan Tyrer,David C. Christiani,Yongyue Wei,Hongbing Shen,Z. B. Hu,Xiao-Ou Shu,Kouya Shiraishi,Atsushi Takahashi,Yohan Bossé,Ma'en Obeidat,David C. Nickle,Wim Timens,Matthew L. Freedman,Y.Q. Li,D. Seminara,Stephen J. Chanock,Jian Gong,Ulrike Peters,Stephen B. Gruber,Christopher I. Amos,Thomas A. Sellers,Douglas F. Easton,David J. Hunter,Christopher A. Haiman,Brian E. Henderson,Rayjean J. Hung,Ocac,Res Hereditary Breast Ovarian Canc,Transdisciplinary Colorectal,Canc African Amer Breast,Canc African Ancestry Prostate +136 more
TL;DR: This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.
Journal ArticleDOI
Guidelines for follow-up of women at high risk for inherited breast cancer: consensus statement from the Biomed 2 Demonstration Programme on Inherited Breast Cancer.
Peter Möller,D. Gareth Evans,Neva E. Haites,Hans F. A. Vasen,Marta M. Reis,E Anderson,Jaran Apold,Shirley Hodgson,D. Eccles,Håkan Olsson,Dominique Stoppa-Lyonnet,Jenny Chang-Claude,Patrick J. Morrison,Generoso Bevilacqua,Ketil Heimdal,Lovise Maehle,Fiona Lalloo,Helen Gregory,P. E. Preece,Åke Borg,N. C. Nevin,Maria A. Caligo,C. M. Steel +22 more
TL;DR: It is proposed that women at high risk for inherited breast cancer be offered genetic counselling, education in ‘breast awareness’ and annual mammography and clinical expert examination from around 30 years of age and all activities should be organized as multicentre studies subjected to continuous evaluation.