J
Justin Guinney
Researcher at Sage Bionetworks
Publications - 129
Citations - 21754
Justin Guinney is an academic researcher from Sage Bionetworks. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 32, co-authored 97 publications receiving 12819 citations. Previous affiliations of Justin Guinney include Duke University & University of Washington.
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Journal ArticleDOI
GSVA: gene set variation analysis for microarray and RNA-seq data.
TL;DR: This work introduces Gene Set Variation Analysis (GSVA), a GSE method that estimates variation of pathway activity over a sample population in an unsupervised manner and constitutes a starting point to build pathway-centric models of biology.
Journal ArticleDOI
The consensus molecular subtypes of colorectal cancer
Justin Guinney,Rodrigo Dienstmann,Rodrigo Dienstmann,Xingwu Wang,Xingwu Wang,Aurélien de Reyniès,Andreas Schlicker,Charlotte Soneson,Laetitia Marisa,Paul Roepman,Gift Nyamundanda,Paolo Angelino,Brian M. Bot,Jeffrey S. Morris,Iris Simon,Sarah Gerster,Evelyn Fessler,Felipe De Sousa E Melo,Edoardo Missiaglia,Hena R. Ramay,David Barras,Krisztian Homicsko,Dipen M. Maru,Ganiraju C. Manyam,Bradley M. Broom,Valérie Boige,Beatriz Perez-Villamil,Ted Laderas,Ramon Salazar,Joe W. Gray,Douglas Hanahan,Josep Tabernero,René Bernards,Stephen H. Friend,Pierre Laurent-Puig,Jan Paul Medema,Anguraj Sadanandam,Lodewyk F. A. Wessels,Mauro Delorenzi,Mauro Delorenzi,Scott Kopetz,Louis Vermeulen,Sabine Tejpar +42 more
TL;DR: An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features.
Journal ArticleDOI
The Immune Landscape of Cancer
Vesteinn Thorsson,David L Gibbs,Scott D. Brown,Denise M. Wolf,Dante S. Bortone,Tai-Hsien Ou Yang,Eduard Porta-Pardo,Galen F. Gao,Christopher L. Plaisier,James A. Eddy,Elad Ziv,Aedín C. Culhane,Evan O. Paull,I K Ashok Sivakumar,Andrew J. Gentles,Raunaq Malhotra,Farshad Farshidfar,Antonio Colaprico,Joel S. Parker,Lisle E. Mose,Nam S Vo,Jianfang Liu,Yuexin Liu,Janet S. Rader,Varsha Dhankani,Sheila Reynolds,Reanne Bowlby,Andrea Califano,Andrew D. Cherniack,Dimitris Anastassiou,Davide Bedognetti,Arvind Rao,Ken Chen,Alexander Krasnitz,Hai Hu,Tathiane M. Malta,Houtan Noushmehr,Houtan Noushmehr,Chandra Sekhar Pedamallu,Susan Bullman,Akinyemi I. Ojesina,Andrew Lamb,Wanding Zhou,Hui Shen,Toni K. Choueiri,John N. Weinstein,Justin Guinney,Joel H. Saltz,Robert A. Holt,Charles E Rabkin,Alexander J. Lazar +50 more
TL;DR: An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis.
Journal ArticleDOI
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
Gregory Hannum,Justin Guinney,Ling Zhao,Ling Zhao,Li Zhang,Guy Hughes,Srinivas R. Sadda,Brandy Klotzle,Marina Bibikova,Jian-Bing Fan,Yuan Gao,Rob Deconde,Menzies Chen,Indika Rajapakse,Stephen H. Friend,Trey Ideker,Kang Zhang,Kang Zhang +17 more
TL;DR: A quantitative model of aging is built using measurements at more than 450,000 CpG markers from the whole blood of 656 human individuals, aged 19 to 101, to measure the rate at which an individual's methylome ages, which is impacted by gender and genetic variants.
Journal ArticleDOI
AACR project genie: Powering precision medicine through an international consortium
Shawn M. Sweeney,Ethan Cerami,Alexander S. Baras,Trevor J. Pugh,Nikolaus Schultz,Thomas Stricker,James Lindsay,C. Del Vecchio Fitz,Priti Kumari,Christine M. Micheel,K. Shaw,Jianjiong Gao,Nicola Moore,Cyriac Kandoth,Brendan Reardon,Eva M Lepisto,Stuart Gardos,Kristen K. Dang,Justin Guinney,Larsson Omberg,Thomas Yu,Benjamin Gross,Zachary J. Heins,David M. Hyman,Barrett J. Rollins,Charles L. Sawyers,David B. Solit,Deborah Schrag,Victor E. Velculescu,Fabrice Andre,Philippe L. Bedard,Mia Levy,Gerrit A. Meijer +32 more