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Katja Hönzke
Researcher at Charité
Publications - 12
Citations - 335
Katja Hönzke is an academic researcher from Charité. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 4 publications receiving 83 citations.
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Journal ArticleDOI
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Emanuel Wyler,Kirstin Mösbauer,Vedran Franke,Asija Diag,Lina Theresa Gottula,Roberto Arsie,Filippos Klironomos,Filippos Klironomos,David Koppstein,Katja Hönzke,Salah Ayoub,Christopher Buccitelli,Karen Hoffmann,Anja Richter,Ivano Legnini,Andranik Ivanov,Tommaso Mari,Simone Del Giudice,Jan Papies,Samantha D. Praktiknjo,Thomas F. Meyer,Marcel A. Müller,Daniela Niemeyer,Andreas C. Hocke,Matthias Selbach,Altuna Akalin,Nikolaus Rajewsky,Christian Drosten,Markus Landthaler,Markus Landthaler +29 more
TL;DR: In this article, gene expression profiles of three SARS-CoV and SARS CoV-2 infected human cell lines were reported, and it was shown that SARS co-virus infection elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS in the human epithelial cell line Calu-3, including induction of miRNA-155.
Journal ArticleDOI
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Jackson Emanuel,Jackson Emanuel,Frederik Dethloff,Robert Lorenz Chua,Jakob Trimpert,Nicolas Heinemann,Nicolas Heinemann,Christine Niemeyer,Friderike Weege,Friderike Weege,Katja Hönzke,Tom Aschman,Daniel E. Heinz,Katja Weckmann,Tim Ebert,Andreas Zellner,M. Lennarz,Emanuel Wyler,Simon Schroeder,Simon Schroeder,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Karen Hoffmann,Thomas F. Meyer,Frank L. Heppner,Frank L. Heppner,Victor M. Corman,Victor M. Corman,Markus Landthaler,Markus Landthaler,Andreas C. Hocke,Markus Morkel,Markus Morkel,Nikolaus Osterrieder,Nikolaus Osterrieder,Christian Conrad,Roland Eils,Roland Eils,Helena Radbruch,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller +48 more
TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Journal ArticleDOI
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
Katja Hönzke,Benedikt Obermayer,C. Mache,Diana Fathykova,Mirjana Kessler,Simon Dökel,Emanuel Wyler,Morris Baumgardt,Anna Löwa,Karen Hoffmann,Patrick Graff,Jessica Schulze,Maren Mieth,Katharina Hellwig,Zeynep Demir,Barbara Biere,Linda Brunotte,Angeles Mecate-Zambrano,Judy Bushe,Melanie Dohmen,Christian Hinze,Sefer Elezkurtaj,Mario Tönnies,Th. Bauer,S Eggeling,Hong-Linh Tran,Paul M. Schneider,Jens Neudecker,Jens C. Rückert,Kai M. Schmidt-Ott,Jonas Busch,Frederick Klauschen,David Horst,Helena Radbruch,Josefine Radke,Frank L. Heppner,Victor M. Corman,Daniela Niemeyer,Marcel A. Müller,Christine Goffinet,Ronja Mothes,Anna Pascual-Reguant,Anja E. Hauser,Dieter Beule,Markus Landthaler,Stephan Ludwig,Norbert Suttorp,Martin Witzenrath,Achim D. Gruber,Christian Drosten,Leif E. Sander,Thorsten Wolff,Stefan Hippenstiel,A. Hocker +53 more
TL;DR: It is indicated that severe lung injury in COVID-19 likely results from a macrophage triggered immune activation rather than direct viral damage of the alveolar compartment, thereby limiting SARS-CoV-2 propagation and virus-induced tissue damage in the human alveolus.
Journal ArticleDOI
Human Lungs Show Limited Permissiveness for SARS-CoV-2 Due to Scarce ACE2 Levels But Strong Virus-Induced Immune Activation in Alveolar Macrophages
Katja Hönzke,Benedikt Obermayer,Christin Mache,Diana Fatykhova,Mirjana Kessler,Simon Dökel,Emanuel Wyler,Katrin Hoffmann,Jessica Schulze,Maren Mieth,Katharina Hellwig,Biere B,Brunotte L,Mecate-Zambrano A,Judith Hoppe,Melanie Dohmen,Christian Hinze,Sefer Elezkurtaj,Mario Tönnies,Torsten T. Bauer,Stephan Eggeling,Tran H,Paul M. Schneider,Jens Neudecker,Jens-Carsten Rückert,Kai M. Schmidt-Ott,Jonas Busch,Frederick Klauschen,David Horst,Helena Radbruch,Frank L. Heppner,Victor M. Corman,Daniela Niemeyer,Marcel A. Müller,Christine Goffinet,Dieter Beule,Markus Landthaler,Stephan Ludwig,Niedobitek G,Norbert Suttorp,Martin Witzenrath,Achim D. Gruber,Christian Drosten,LE Sander,Thorsten Wolff,Stefan Hippenstiel,Andreas C. Hocke +46 more
TL;DR: The findings indicate that severe lung injury in COVID-19 likely results from an overwhelming immune activation rather than direct viral damage of the alveolar compartment, thereby limiting SARS-CoV-2 propagation in the human alveolus.
Journal ArticleDOI
Reversion of Pneumolysin-Induced Executioner Caspase Activation Redirects Cells to Survival.
Andreas Nerlich,Andreas Nerlich,Iris von Wunsch Teruel,Maren Mieth,Katja Hönzke,Jens C. Rückert,Timothy J. Mitchell,Norbert Suttorp,Stefan Hippenstiel,Andreas C. Hocke +9 more
TL;DR: In this article, the authors used machine learning and quantitative live-cell microscopy to identify a significant number of alveolar epithelial cells surviving such executioner caspase activation after pneumolysin attack.